Generic Name: cyclophosphamide (SYE-kloe-FOS-fa-mide)
Brand Name: Generic only. No brands available.
Cyclophosphamide capsules are used for:
Treating certain types of the following cancers: lymphoma, multiple myeloma, leukemia, mycosis fungoides, neuroblastoma, ovarian cancer, eye cancer, and breast cancer. It is usually used in combination with other medicines. It may also be used to treat certain kidney problems (nephrotic syndrome) in children or for other conditions as determined by your doctor.
Cyclophosphamide capsules are an antineoplastic. It works by stopping or slowing the growth or spread of certain cancer cells.
Do NOT use cyclophosphamide capsules if:
- you are allergic to any ingredient in cyclophosphamide capsules or to other similar medicines
- you have a urinary blockage
Contact your doctor or health care provider right away if any of these apply to you.
Before using cyclophosphamide capsules:
Some medical conditions may interact with cyclophosphamide capsules. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have an infection, chickenpox, or bone marrow problems (eg, low blood platelet levels, low red blood cell levels, low white blood cell levels)
- if you have a history of heart, lung, liver, thyroid, or kidney problems
- if you have had an adrenal gland removed (adrenalectomy)
- if you are receiving or have received chemotherapy or radiation therapy
Some MEDICINES MAY INTERACT with cyclophosphamide capsules. Tell your health care provider if you are taking any other medicines, especially any of the following:
- TNF-blocking medicines (eg, etanercept) because the risk of certain types of cancer may be increased
- Anthracyclines (eg, doxorubicin), cytarabine, pentostatin, or trastuzumab because the risk of heart-related side effects and toxicity may be increased
- Anticoagulants (eg, warfarin) because their effectiveness may be decreased and the risk of bleeding may be increased
- Tamoxifen because the risk of blood clots may be increased
- Amiodarone, amphotericin B, angiotensin-converting enzyme (ACE) inhibitors (eg, lisinopril), azathioprine, busulfan, filgrastim, indomethacin, natalizumab, paclitaxel, pegfilgrastim, protease inhibitors (eg, ritonavir, boceprevir), thiazide diuretics (eg, hydrochlorothiazide), or zidovudine because they may increase the risk of cyclophosphamide capsules's side effects
- Cyclosporine because its effectiveness may be decreased by cyclophosphamide capsules
This may not be a complete list of all interactions that may occur. Ask your health care provider if cyclophosphamide capsules may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use cyclophosphamide capsules:
Use cyclophosphamide capsules as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Take cyclophosphamide capsules by mouth with or without food in the morning.
- Swallow cyclophosphamide capsules whole. Do not break, crush, or chew before swallowing. Do not open capsules before swallowing.
- Wear gloves when handling cyclophosphamide capsules. Avoid contact with broken capsules and tablets. If cyclophosphamide capsules gets on your skin, wash it off right away with soap and water.
- If you experience nausea, vomiting, diarrhea, or loss of appetite, contact your doctor to discuss ways to reduce these side effects.
- Drinking extra fluids and emptying your bladder regularly while you are taking cyclophosphamide capsules is recommended. Check with your doctor for instructions.
- If you miss a dose of cyclophosphamide capsules, contact your doctor right away.
Ask your health care provider any questions you may have about how to use cyclophosphamide capsules.
Important safety information:
- Cyclophosphamide capsules may cause dizziness or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use cyclophosphamide capsules with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Cyclophosphamide capsules can lower the ability of your bone marrow to make blood cells that your body needs. This may lead to severe and sometimes fatal problems (eg, infections). Discuss any questions or concerns with your doctor.
- Cyclophosphamide capsules may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.
- Cyclophosphamide capsules may lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.
- Do not receive a live vaccine (eg, measles, mumps) while you are taking cyclophosphamide capsules. Talk with your doctor before you receive any vaccine.
- Tell your doctor or dentist that you take cyclophosphamide capsules before you receive any medical or dental care, emergency care, or surgery.
- Severe and sometimes fatal urinary tract, heart, lung, and liver problems have been reported in patients taking cyclophosphamide capsules. Discuss any questions or concerns with your doctor.
- Cyclophosphamide capsules may decrease your body's ability to heal wounds. Discuss any questions or concerns with your doctor.
- Cyclophosphamide capsules may increase your chance of developing a second cancer, sometimes even years after stopping treatment with cyclophosphamide capsules. Discuss any questions or concerns with your doctor.
- Cyclophosphamide capsules may cause infertility that is sometimes permanent. Discuss any questions or concerns with your doctor.
- Low blood sodium levels may occur from treatment with cyclophosphamide capsules. In severe cases, this can be deadly. Discuss any questions or concerns with your doctor.
- If you are able to become pregnant, you must use an effective form of birth control while you take cyclophosphamide capsules and for 1 year after you stop treatment. If you have questions about effective birth control, talk with your doctor.
- Men who take cyclophosphamide capsules must use a condom during sexual contact with women who are pregnant or may become pregnant. Do this during treatment with cyclophosphamide capsules and for at least 4 months after treatment is stopped. If your female partner becomes pregnant, contact your doctor.
- Lab tests may be performed while you use cyclophosphamide capsules. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- Use cyclophosphamide capsules with caution in the ELDERLY; they may be more sensitive to its effects.
- PREGNANCY and BREAST-FEEDING: Cyclophosphamide capsules may cause harm to the fetus. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using cyclophosphamide capsules while you are pregnant. Cyclophosphamide capsules are found in breast milk. Do not breast-feed while taking cyclophosphamide capsules.
Possible side effects of cyclophosphamide capsules:
All medicines may cause side effects, but many people have no, or minor side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Appetite loss; absence of menstrual periods; color change in skin; diarrhea; hair loss; nausea; stomach discomfort or pain; texture change in nails; vomiting.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody, black, or tarry stools; chest pain; fainting; fast, slow, or irregular heartbeat; red, swollen, or blistered skin; severe or persistent dizziness; severe or persistent stomach pain; shortness of breath; sores in the mouth or on the tongue; sudden, unusual weight gain; swelling of the hands, ankles, or feet; symptoms of infection (eg, fever, chills, cough, sore throat, burning or painful urination); symptoms of kidney or urinary tract problems (eg, blood in the urine, change in the amount of urine produced, lower back pain, red or pink urine); symptoms of liver problems (eg, dark urine, pale stools, persistent loss of appetite, severe stomach pain, yellowing of the skin or eyes); symptoms of low blood sodium levels (eg, confusion, decreased coordination, fainting, hallucinations, headache, memory problems, mental or mood changes, seizures, sluggishness, trouble concentrating, weakness); unusual bruising or bleeding; unusual or severe tiredness or weakness.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.Proper storage of cyclophosphamide capsules:
Store cyclophosphamide capsules at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep cyclophosphamide capsules out of the reach of children and away from pets.
- If you have any questions about cyclophosphamide capsules, please talk with your doctor, pharmacist, or other health care provider.
- Cyclophosphamide capsules are to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take cyclophosphamide capsules or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about cyclophosphamide capsules. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to cyclophosphamide capsules. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using cyclophosphamide capsules.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
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