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Xpovio Side Effects

Generic name: selinexor

Medically reviewed by Drugs.com. Last updated on Oct 28, 2024.

Note: This document provides detailed information about Xpovio.

Applies to selinexor: oral tablet Side Effects associated with selinexor. Some dosage forms listed on this page may not apply specifically to the brand name Xpovio.

Applies to selinexor: oral tablet.

Precautions

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood tests may be needed to check for unwanted effects.

Using this medicine while you are pregnant can harm your unborn baby. It may also cause birth defects if the father is using it when his sexual partner becomes pregnant. If you are a woman who can bear children, your doctor may give you a pregnancy test before you start using this medicine to make sure you are not pregnant. Female patients should use effective birth control during treatment and for at least 1 week after the last dose. Male patients who have female partners should use effective birth control during treatment and for at least 1 week after the last dose. If you think you have become pregnant while using this medicine, tell your doctor right away.

Selinexor can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. It can also lower the number of platelets, which are necessary for proper blood clotting. If this occurs, there are certain precautions you can take, especially when your blood count is low, to reduce the risk of infection or bleeding:

Nausea, vomiting, diarrhea, loss of appetite, or weight loss may occur with selinexor (the active ingredient contained in Xpovio) which can be severe and cause dehydration. Your doctor may give you medicine or other treatments for these. Check with your doctor right away if you notice that you are losing weight or have a decrease in appetite.

This medicine may make you dizzy or confused. Do not drive or do anything else that could be dangerous until you know how this medicine affects you. Tell your doctor if you are using other medicine that cause dizziness or mental changes.

This medicine may cause hyponatremia (low sodium levels in the blood). Check with your doctor right away if you have loss of consciousness, confusion, seizures, decreased urine output dizziness, fast or irregular heartbeat, muscle pain or cramps, trouble breathing, swelling of the face, ankles, or hands, or unusual tiredness or weakness.

This medicine may cause serious infections. Check with your doctor right away if you have chest pain, fever or chills, confusion, cough or hoarseness, dizziness, fainting, fast heartbeat, lightheadedness, lower back or side pain, painful or difficult urination, sneezing, sore throat, tightness in the chest, or trouble breathing.

This medicine may cause brain or nerve problems. Check with your doctor right away if you have blurred or double vision, confusion as to time, place, or person, difficulty in walking, dizziness, drooping eyelids, fainting, hallucinations, headache, holding false beliefs that cannot be changed by fact, jaw pain, loss of memory, numbness or tingling in the fingers and toes, pain in the fingers and toes, pain in the testicles, problems with memory, unusual excitement, nervousness, or restlessness, or weakness.

This medicine may cause eye problems (eg, cataracts). Check with your doctor immediately if blurred vision, difficulty in reading, or any other change in vision occurs during or after treatment. Your doctor may want you to have your eyes checked by an ophthalmologist (eye doctor).

This medicine could cause infertility in some men and women. Talk with your doctor before using this medicine if you plan to have children.

Serious side effects of Xpovio

Along with its needed effects, selinexor may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking selinexor:

More common side effects

  • black, tarry stools
  • bladder pain
  • bleeding gums
  • blindness
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • bloody or cloudy urine
  • blurred or decreased vision
  • body aches or pain
  • bone pain
  • burning, numbness, tingling, or painful sensations
  • chest pain or tightness
  • chills
  • confusion
  • cough
  • coughing up blood
  • decreased urination
  • diarrhea
  • difficult, burning, or painful urination
  • difficulty in breathing or swallowing
  • dizziness
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • dry mouth
  • ear congestion
  • fainting
  • fast or irregular heartbeat
  • fever
  • flushed, dry skin
  • fruit-like breath odor
  • hallucinations
  • headache
  • hoarseness
  • holding false beliefs that cannot be changed by fact
  • increase in heart rate
  • increased hunger or thirst
  • increased menstrual flow or vaginal bleeding
  • increased urination
  • lightheadedness
  • loss of appetite
  • loss of consciousness
  • loss of voice
  • lower back or side pain
  • mental or mood changes
  • muscle cramps or pain
  • nausea
  • nosebleeds
  • numbness or tingling in the hands, feet, or lips
  • painful or difficult urination
  • pale skin
  • paralysis
  • pinpoint red spots on the skin
  • problems with memory
  • prolonged bleeding from cuts
  • rapid breathing
  • red or black, tarry stools
  • red or dark brown urine
  • runny or stuffy nose
  • seizures
  • sneezing
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • stomach pain
  • sunken eyes
  • sweating
  • swollen glands
  • tingling of the hands or feet
  • ulcers, sores, or white spots in the mouth
  • unsteadiness or awkwardness
  • unusual bleeding or bruising
  • unusual excitement, nervousness, or restlessness
  • unusual tiredness or weakness
  • unusual weight gain or loss
  • vomiting
  • weakness in the arms, hands, legs, or feet
  • wrinkled skin

Less common side effects

  • burning or stinging of the skin
  • dilated neck veins
  • painful cold sores or blisters on the lips, nose, eyes, or genitals

Other side effects of Xpovio

Some side effects of selinexor may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

For healthcare professionals

Applies to selinexor: oral tablet.

Hematologic adverse events

Immunologic

Ocular

Metabolic

Psychiatric

Respiratory

Other

Nervous system

Renal

Gastrointestinal

See also:

References

1. (2019) "Product Information. Xpovio (selinexor)." Karyopharm Therapeutics

Further information

Xpovio side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.