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Xpovio Side Effects

Generic name: selinexor

Medically reviewed by Last updated on Apr 28, 2023.

Note: This document contains side effect information about selinexor. Some dosage forms listed on this page may not apply to the brand name Xpovio.

Applies to selinexor: oral tablet.

Serious side effects of Xpovio

Along with its needed effects, selinexor (the active ingredient contained in Xpovio) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking selinexor:

More common

Less common

Other side effects of Xpovio

Some side effects of selinexor may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

For Healthcare Professionals

Applies to selinexor: oral tablet.


Very common (10% or more): Thrombocytopenia (74%), anemia/ hematocrit decreased (59%), neutropenia (34%), leukopenia (28%), bleeding (23%), lymphopenia (15%)[Ref]


Very common (10% or more): Infections (52%)[Ref]


Very common (10% or more): Blurred vision (10%)[Ref]


Very common (10% or more): Anorexia (53%), weight loss (47%), hyponatremia (39%), hyperglycemia (15%), dehydration (14%)[Ref]


Very common (10% or more): Confusion/delirium (30%), mental status changes (16%), insomnia (15%)[Ref]


Very common (10% or more): Dyspnea (24%), upper respiratory infection (21%), cough (16%), pneumonia (e.g., pneumonia, atypical pneumonia, lung infection, lower respiratory tract infection, pneumocystis jirovecii pneumonia, pneumonia aspiration, pneumonia influenza pneumonia viral) (13%), epistaxis (12%)[Ref]


Very common (10% or more): Fatigue/asthenia (73%), pyrexia (16%)[Ref]

Nervous system

Very common (10% or more): Dizziness (15%), dysgeusia (11%), headache (10%)

Frequency not reported: Syncope, depressed level of consciousness[Ref]


Very common (10% or more): Hypercreatininemia (14%)[Ref]


Very common (10% or more): Nausea (72%), diarrhea (44%), vomiting (41%), constipation (25%)[Ref]


1. Product Information. Xpovio (selinexor). Karyopharm Therapeutics. 2019.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.