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Xpovio 40 mg once-weekly

Generic name: selinexorSEL-i-NEX-or ]
Brand names: Xpovio 100 mg once-weekly, Xpovio 40 mg once-weekly, Xpovio 40 mg twice-weekly, Xpovio 60 mg once-weekly, Xpovio 60 mg twice-weekly, Xpovio 80 mg once-weekly, Xpovio 80 mg twice-weekly
Drug class: Miscellaneous antineoplastics

Medically reviewed by on Aug 21, 2023. Written by Cerner Multum.

What is Xpovio 40 mg once-weekly?

Xpovio 40 mg once-weekly is used together with bortezomib and/or dexamethasone to treat multiple myeloma in adults.

Xpovio 40 mg once-weekly is also used in adults to treat certain types of diffuse large B-cell lymphoma.

Xpovio 40 mg once-weekly is given after other medications did not work or have stopped working.

Xpovio 40 mg once-weekly was approved by the US Food and Drug Administration (FDA) on an "accelerated" basis. In clinical studies, some people responded to Xpovio 40 mg once-weekly, but further studies are needed.

Xpovio 40 mg once-weekly may also be used for purposes not listed in this medication guide.

Xpovio 40 mg once-weekly side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Xpovio 40 mg once-weekly can cause serious or fatal side effects. Some side effects may not occur until you have been taking this medicine for several days or weeks.

Xpovio 40 mg once-weekly may cause serious side effects. Call your doctor at once if you have:

Your treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects of Xpovio 40 mg once-weekly may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


You may get infections more easily, even serious or fatal infections. Call your doctor if you have a fever, chills, flu symptoms, cough, mouth ulcers, or trouble breathing,

Xpovio 40 mg once-weekly can also cause low platelet counts in your blood. Tell your doctor right away if you have unusual bruising or bleeding.

Before taking this medicine

Tell your doctor if you have ever had:

You may need to have a negative pregnancy test before starting this treatment.

Both men and women using Xpovio 40 mg once-weekly should use effective birth control to prevent pregnancy. Xpovio 40 mg once-weekly can harm an unborn baby if the mother or father is using this medicine.

Keep using birth control for at least 1 week after your last dose. Tell your doctor right away if a pregnancy occurs while either the mother or the father is using Xpovio 40 mg once-weekly.

This medicine may affect fertility (ability to have children) in both men and women. However, it is important to use birth control to prevent pregnancy because Xpovio 40 mg once-weekly can harm an unborn baby.

Do not breastfeed while using this medicine, and for at least 1 week after your last dose.

Not approved for use by anyone younger than 18 years old.

How should I take Xpovio 40 mg once-weekly?

Your doctor will perform tests to make sure Xpovio 40 mg once-weekly is the right treatment for you.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Xpovio 40 mg once-weekly is usually taken only on specific days, once or twice per week. Follow your doctor's instructions very carefully about when and how to take this medicine with dexamethasone and/or bortezomib.

Your doctor will determine how long to treat you with Xpovio 40 mg once-weekly and dexamethasone.

Take Xpovio 40 mg once-weekly with a full glass of water. Swallow the tablet whole and do not crush, chew, or break it.

If you vomit shortly after taking Xpovio 40 mg once-weekly, do not take another dose. Take your next dose as scheduled.

You may be given other medications to help prevent nausea, vomiting, or infections. Keep taking these medicines for as long as your doctor has prescribed.

You may get infections more easily, even serious or fatal infections. You will need frequent medical tests. You may need a transfusion if your blood platelets get too low.

Your blood sodium levels will need to be tested. If the levels get too low, your doctor may prescribe salt tablets or intravenous (IV) fluids to keep you from getting dehydrated.

Drink plenty of liquids to prevent dehydration, and eat enough calories to prevent weight loss.

Xpovio 40 mg once-weekly can affect your appetite or ability to eat. You will be weighed before and during treatment to make sure you are not losing weight while taking this medicine.

Store at room temperature away from moisture and heat. Keep each Xpovio 40 mg once-weekly tablet in the blister pack until you are ready to take your dose.

What happens if I miss a dose?

Skip the missed dose and use your next dose at the regular time. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Xpovio 40 mg once-weekly?

Avoid driving or hazardous activity until you know how Xpovio 40 mg once-weekly will affect you. Your reactions could be impaired.

What other drugs will affect Xpovio 40 mg once-weekly?

Other drugs may affect Xpovio 40 mg once-weekly, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.