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Daratumumab Side Effects

For the Consumer

Applies to daratumumab: intravenous solution

In addition to its needed effects, some unwanted effects may be caused by daratumumab. In the event that any of these side effects do occur, they may require medical attention.

If any of the following side effects occur while taking daratumumab, check with your doctor or nurse immediately:

More common:
  • Blurred vision
  • body aches or pain
  • chest pain or tightness
  • dizziness
  • ear congestion
  • fever or chills
  • facial swelling
  • headache
  • loss of voice
  • nausea or vomiting
  • nervousness
  • pounding in the ears
  • shortness of breath
  • slow or fast heartbeat
  • sneezing
  • sore throat
  • stuffy or runny nose
  • trouble breathing
Less common:
  • Confusion
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • painful blisters on the trunk of body
  • skin rash, hives, or itching
  • sweating
  • unusual tiredness or weakness

Minor Side Effects

Some of the side effects that can occur with daratumumab may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Back pain
  • constipation
  • cough
  • diarrhea
  • difficulty in moving
  • joint pain
  • loss of appetite
  • muscle pain or stiffness
  • nausea
  • pain in the arms or legs
  • vomiting

For Healthcare Professionals

Applies to daratumumab: intravenous solution

Cardiovascular

Very common (10% or more): Hypertension (10%)[Ref]

Gastrointestinal

Very common (10% or more): Nausea (27%), diarrhea (16%), constipation (15%), vomiting (14%)[Ref]

Hematologic

Very common (10% or more): Lymphopenia (72%), neutropenia (60%), thrombocytopenia (48%), anemia (45%)[Ref]

Immunologic

Common (1% to 10%): Pneumonia (e.g., streptococcal pneumonia, lobar pneumonia), herpes zoster reactivation[Ref]

Local

Very common (10% or more): Infusion reaction (48%)[Ref]

Metabolic

Very common (10% or more): Decreased appetite (15%)[Ref]

Musculoskeletal

Very common (10% or more): Back pain (23%), arthralgia (17%), pain in extremity (15%), musculoskeletal chest pain (12%)[Ref]

Nervous system

Very common (10% or more): Headache (12%)[Ref]

Respiratory

Very common (10% or more): Cough (21%), upper respiratory tract infection (20%), nasal congestion (17%), dyspnea (15%), nasopharyngitis (15%), vomiting (14%)
Common (1% to 10%): Bronchospasm, dyspnea, hypoxia
Uncommon (0.1% to 1%): Allergic rhinitis allergic, throat irritation[Ref]

References

1. "Product Information. Darzalex (daratumumab)." Janssen Biotech, Inc., Horsham, PA, PA.

Not all side effects for daratumumab may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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