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Proteasome inhibitors

What are Proteasome inhibitors?

Proteasomes are protease complexes which are responsible for degrading endogenous proteins. Proteins to be destroyed are recognized by proteasomes because of the presence of ubiquitin conjugated to the targeted protein. The ubiquitin-proteasome pathway plays an essential role in regulating the intracellular concentration of specific proteins, thereby maintaining homeostasis within cells. Proteasome inhibitors prevent this targeted decomposition of protein, which can affect multiple signaling cascades within the cell. This disruption of normal homeostatic mechanisms can lead to cell death. Proteasome inhibitors may be used to treat multiple myeloma and certain types of lymphoma.

List of Proteasome inhibitors

View by  Brand | Generic
Drug Name Avg. Rating Reviews
Velcade (Pro)
Generic name: bortezomib
6 reviews
Ninlaro (Pro)
Generic name: ixazomib
3 reviews
Kyprolis (Pro)
Generic name: carfilzomib
3 reviews
For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective).

See also

Medical conditions treated or associated with proteasome inhibitors:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.