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Generic name: teclistamab
Brand name: Tecvayli
Dosage form: subcutaneous solution (cqyv 10 mg/mL; cqyv 90 mg/mL)
Drug class: Bispecific T-cell engagers (BiTE)

Medically reviewed by on Jun 18, 2024. Written by Cerner Multum.

What is teclistamab?

Teclistamab is used to treat adults with multiple myeloma who have received at least 4 treatment regimens and their cancer has returned or did not respond to a previous treatment.

Teclistamab is available only from a certified pharmacy under a special program. You must be registered in the program and understand the risks and benefits of teclistamab.

Teclistamab may also be used for purposes not listed in this medication guide.

Teclistamab side effects

Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.

Tell your medical caregivers if you have signs of cytokine release syndrome (CRS), a serious side effect: fever, chills, trouble breathing, confusion, severe vomiting or diarrhea, fast or irregular heartbeats, feeling light-headed or very tired.

Teclistamab may cause serious side effects. Call your doctor at once if you have:

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects of teclistamab may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Call your doctor if you have symptoms of neurological problems such as headache, unusual muscle problems or pain, numbness and tingling, tremor, double vision, walking difficulties, handwriting or speech changes, or hearing loss.

Tell your medical caregivers if you have symptoms of a serious side effect, such as fever, chills, trouble breathing, vomiting, or severe tiredness.

Before taking this medicine

Tell your doctor if you have or have ever had:

May harm an unborn baby. You may need a pregnancy test to make sure you are not pregnant. Use effective birth control while receiving teclistamab and for at least 5 months after your last dose. Tell your doctor right away if you become pregnant.

Do not breastfeed while receiving teclistamab, and for at least 5 months after your last dose.

How is teclistamab given?

Follow all directions on your prescription label and read all medication guides or instruction sheets.

Read the Patient Wallet Card about serious side effects and learn what symptoms to watch for. Keep the card with you at all times.

Teclistamab is given by a healthcare provider as an injection under the skin in the stomach-area, thigh, or another area of your body.

Doses are based on weight. Your dose may change if you gain or lose weight.

You will need to stay in the hospital for 48 hours after some doses of teclistamab. Talk with your doctor if you have any questions.

Your doctor will determine the right treatment schedule for you.

You may be given other medications to help prevent serious side effects. Keep using these medicines for as long as your doctor has prescribed. Your doctor will monitor you for these side effects.

You will need frequent medical tests and your cancer treatments may be delayed or discontinued based on the results.

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your teclistamab injection.

What happens if I overdose?

In a medical setting an overdose would be treated quickly.

What should I avoid while receiving teclistamab?

Avoid driving or hazardous activity for 48 hours after receiving certain doses of teclistamab or until neurological symptoms go away. Your reactions could be impaired.

What other drugs will affect teclistamab?

Other drugs may affect teclistamab, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.

Popular FAQ

The active substance in Tecvayli, teclistamab-cqyv, is an antibody that works by activating T-cells (a type of white blood cell) in the immune system to help find and kill multiple myeloma cancer cells in your body. Tecavyli helps to bring together the cancer cell and the T-cell for anti-cancer action. Continue reading

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.