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Generic name: Chlorambucil
Brand name: Leukeran
Dosage form: tablet
Drug class: Alkylating agents

Medically reviewed by Melisa Puckey, BPharm. Last updated on Mar 26, 2024.

What is chlorambucil?

Chlorambucil is an anti-cancer chemotherapy drug used for treatment of Hodgkin's disease and specific types of leukemias and lymphomas. It is from a group of medicines called alkylating agents which acts on cancer cells to slow down or stop their growth. It is a tablet that you swallow with a glass of water.

What is chlorambucil used for?

Chlorambucil is used in the treatment of

It does not cure these conditions but may help with symptoms that you may have. 

This medicine may also be used for conditions not listed here. Talk to your doctor or healthcare provider if you have any questions about chlorambucil being used for any other conditions.


Chlorambucil may:

What should I tell my doctor before taking chlorambucil?

You should not take chlorambucil if:

You should tell your doctor if you have had an allergic reaction to another cancer drug such as bendamustine, busulfan, carmustine, dacarbazine, ifosfamide, lomustine, mechlorethamine, melphalan, streptozocin, or temozolomide.  If you have had an allergic reaction to one of these drugs, it may increase your risk of having an allergic reaction to chlorambucil.

Tell your doctor if you have ever had:

How should I take chlorambucil?

Chlorambucil is a tablet that is usually taken daily for 3 to 6 weeks according to your doctor's treatment plan. Sometimes alternate treatment schedules are used which can be intermittent, biweekly or once a month pulse treatments. 

While on this medicine you must be under the care of a doctor.  You should follow the directions of your doctor and take the medicine exactly as prescribed.

Remember to store your tablets in the refrigerator.

Dosing Information

Your dose of chlorambucil will be worked out according to your condition that you are being treated for, your body weight, whether it is initiation of treatment or a short course.

The dosage may change or be delayed depending on how well you respond to treatment and any change in blood test results.

What happens if I miss a dose? Take the medicine as soon as you can, but if it is almost the same time for your next dose, then skip the missed dose. You should not take two doses at one time.

What happens if I overdose? If you think you have taken too much of this medicine you should get emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include agitation, fast heartbeats, skin rash, bruising, bleeding gums, nosebleeds, trouble breathing, or signs of infection (fever, chills, weakness).

What should I avoid while taking chlorambucil?

Infection risk: Avoid being near people who are sick or have infections, as you may have an increased risk of infection. Tell your doctor at once if you develop signs of infection (high temperature, chills, weakness).

Bleeding or bruising risk: Avoid activities or sports that may increase your risk of bleeding or injury. When shaving or cleaning your teeth be extra careful so that  you do not cause any bleeding. 

Vaccines: You should not receive a "live" vaccine while using chlorambucil. Live vaccines include measles, mumps, rubella (MMR), rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine.

What are the side effects of chlormabucil?

What are the serious (bad) side effects of chlorambucil?
Allergic Reactions:
You should immediately get emergency medical help if you have signs of:

Other serious (bad) side effects:
You should call your doctor at once if you have:

What are the common side effects of chlorambucil? 

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Other drugs may affect chlorambucil, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

To check for interactions with chlorambucil, click the link below.

Pregnancy and breastfeeding

Fertility: Chlorambucil can affect your fertility (your ability to become pregnant or father a child) while taking treatment and afterwards. You should discuss this with your healthcare provider if you are planning on starting a family in the future. Men might be able to store sperm before starting treatment and women might be able to store eggs.
You still may be able to become pregnant, so it is important to use effective birth control while you are using this medicine and for a time afterwards.

Pregnancy: Do not use chlorambucil if you are pregnant or planning a pregnancy. It could harm the unborn baby or cause birth defects. Use effective birth control to prevent pregnancy while taking this medicine. If you are planning a pregnancy you should discuss with your doctor how long after treatment you need to wait before trying to conceive.

Breastfeeding:  It is not known if chlorambucil passes into breast milk.
Many drugs do pass into breast milk and because there is potential for serious adverse reactions to your child if you breastfeed, it is important that you talk to your doctor and make a decision whether you:


How do I store chlorambucil? 


Active ingredient: chlorambucil
Inactive ingredients:
Leukeran. Tablet core: microcrystalline cellulose, anhydrous lactose, colloidal anhydrous silica, stearic acid. Tablet film coating: hypromellose, titanium dioxide, synthetic yellow, iron oxide, synthetic red iron oxide, macrogol.

Manufactured For: Aspen Global Incorporated, GBS Plaza, Cnr La Salette & Royal Roads Grand Bay, Mauritius.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.