Generic name: temozolomide (oral/injection) [ TEM-oh-ZOE-loe-mide ]
Brand name: Temodar
Dosage forms: intravenous powder for injection (100 mg), oral capsule (100 mg; 140 mg; 180 mg; 20 mg; 250 mg; 5 mg)
Drug class: Alkylating agents
What is temozolomide?
Temozolomide is used together with radiation therapy to treat certain types of brain tumor in adults.
Temozolomide is usually given after other treatments have failed.
Temozolomide may also be used for purposes not listed in this medication guide.
Temozolomide side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Temozolomide may cause serious side effects. Call your doctor at once if you have:
a seizure (convulsions);
sudden chest pain or discomfort, wheezing, dry cough;
low blood cell counts--fever, chills, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath; or
Common side effects of temozolomide may include:
headache, feeling tired;
bruising, purple spots;
pain, itching, warmth, redness, swelling, or irritation where the medicine was injected; or
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Call your doctor if you have fever, chills, tiredness, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath.
Before taking this medicine
You should not use temozolomide if you are allergic to temozolomide or dacarbazine.
Tell your doctor if you have ever had:
liver disease; or
Using temozolomide may increase your risk of developing certain types of bone marrow cancer. Ask your doctor about your specific risk.
Temozolomide can harm an unborn baby if the mother or the father is using this medicine.
If you are a woman, you may need a pregnancy test to make sure you are not pregnant. Use birth control while using this medicine and for at least 6 months after your last dose.
If you are a man, use birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3 months after your last dose.
Tell your doctor right away if a pregnancy occurs.
It may be harder for a man to get a woman pregnant while using this medicine. You should still use birth control to prevent pregnancy because the medicine can harm an unborn baby.
Do not breastfeed while using this medicine, and for at least 1 week after your last dose.
How should I use temozolomide?
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
Temozolomide is given in a 28-day treatment cycle and only on certain days of this cycle.
Your doctor may occasionally change your dose. The size, color, and number of temozolomide capsules you take may sometimes be different from earlier treatment cycles. Be sure you know the correct number of capsules to take and on which days to take them. Ask your doctor or pharmacist if you have any questions.
Doses are based on body surface area (height and weight). Your dose may change if you gain or lose weight or if you are still growing.
Temozolomide injection is given by a healthcare provider. The medicine is injected slowly into a vein, over 90 minutes.
Take your entire daily dose of the capsules at the same time on each dosing day of a treatment cycle. Swallow the capsules whole with a full glass of water.
You may take temozolomide capsules with or without food, but take it the same way each time.
You may need to take temozolomide temozolomide capsule at bedtime or on an empty stomach if the medicine upsets your stomach.
If you vomit shortly after taking the medicine, do not take another capsule until your next regularly scheduled dose.
Do not use an open capsule. If the medicine from a broken pill gets in your mouth, eyes, or nose, or on your skin, wash with soap and water (or rinse eyes with water). Ask your pharmacist how to safely dispose of a broken pill.
You may be given medication to prevent nausea or other side effects while you are receiving temozolomide.
Your blood will need to be tested often and your dose or medication schedule may be changed based on the results.
Your liver function may also need to be checked during treatment and for 2 to 4 weeks after you stop using this medicine.
Store temozolomide capsule at room temperature away from moisture and heat.
What happens if I miss a dose?
Call your doctor for instructions if you miss a dose of temozolomide.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while using temozolomide?
Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.
Men should not donate semen while using temozolomide and for at least 90 days after the last dose.
Avoid activities that may increase your risk of bleeding or injury. Use extra care while shaving or brushing your teeth.
What other drugs will affect temozolomide?
Tell your doctor about all your other medicines, especially:
drugs that weaken the immune system such as cancer medicine, steroids, and medicines to prevent organ transplant rejection; or
This list is not complete. Other drugs may affect temozolomide, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
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- Drug class: alkylating agents
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Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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