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Thiotepa

Generic name: thiotepa [ THYE-oh-TEP-a ]
Brand names: Tepadina, Thioplex
Dosage form: injectable powder for injection (100 mg; 15 mg)
Drug class: Alkylating agents

Medically reviewed by Drugs.com on Aug 14, 2023. Written by Cerner Multum.

What is thiotepa?

Thiotepa is used to treat cancer of the breast, ovary, bladder, and certain body cavities.

Thiotepa may also be used for purposes not listed in this medication guide.

Thiotepa side effects

Get emergency medical help if you have signs of an allergic reaction: hives; wheezing, difficult breathing; swelling of your face, lips, tongue, or throat.

Thiotepa may cause serious side effects. Call your doctor at once if you have:

Common side effects of thiotepa may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Warnings

Thiotepa can increase your risk of bleeding or infection. Call your doctor if you have unusual bruising or bleeding, or new signs of infection (fever, chills, mouth sores, pale skin, tiredness, feeling short of breath).

Before taking this medicine

You should not be treated with thiotepa if you are allergic to it, or if you have recently received a vaccine.

Tell your doctor if you have ever had:

Tell your doctor about all other cancer treatments you have recently received, including chemotherapy and radiation.

Using thiotepa may increase your risk of developing other cancers, such as leukemia. Ask your doctor about this risk.

Tell your doctor if you are planning a pregnancy. Both men and women must prevent pregnancy during treatment with thiotepa and for several months afterward.

Thiotepa can harm an unborn baby if the mother or the father is using thiotepa.

This medicine may affect fertility (ability to have children) in both men and women. However, it is important to use birth control to prevent pregnancy because thiotepa can harm an unborn baby.

You should not breastfeed while using thiotepa.

How is thiotepa given?

Thiotepa is given as an infusion into a vein, or injected directly into the bladder or other body cavity. A healthcare provider will give you this injection.

When injected into the bladder, you will need to hold the medicine inside your bladder for 2 hours. Tell your caregivers if this causes you a great deal of discomfort. You may need to receive a smaller amount of the medicine to hold it comfortably in your bladder.

Thiotepa is usually given once every 1 to 4 weeks. Follow your doctor's dosing instructions very carefully.

Thiotepa can increase your risk of bleeding or infection. You will need frequent medical tests.

Thiotepa can be dangerous if it gets in your mouth, eyes, or nose, or on your skin. If this happens, wash your skin with soap and water or rinse your eyes with water.

Being treated with thiotepa may cause itching, blistering, peeling, or discoloration (especially in the skin folds of your groin, underarms, or neck). Bathe or shower and wash your skin with soap and water at least 2 times per day for at least 48 hours after each time you receive this medicine.

If you cover the skin with any bandaging, change the dressing and clean the covered skin at 2 times per day for 48 hours after each time you receive thiotepa.

Change your bed sheets every day during treatment.

Thiotepa can increase your risk of bleeding or infection. You will need frequent medical tests.

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your thiotepa injection.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include signs of infection such as fever or chills.

What should I avoid while receiving thiotepa?

Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.

Do not receive a "live" vaccine while using thiotepa, or you could develop a serious infection. Live vaccines include measles, mumps, rubella (MMR), rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine.

What other drugs will affect thiotepa?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Other drugs may affect thiotepa, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.