Skip to main content

Thiotepa Side Effects

Medically reviewed by Drugs.com. Last updated on Aug 23, 2024.

Applies to thiotepa: injection powder for solution.

Precautions

Your doctor will check your progress closely while you are receiving this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it. Blood tests may be needed to check for unwanted effects.

Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control for at least 6 months after treatment ends to keep from getting pregnant. Men should not father a child for at least 1 year after treatment ends. If you think you have become pregnant while using this medicine, tell your doctor right away.

Do not receive live vaccines without your doctor's approval while you are using this medicine.

This medicine may cause serious allergic reactions, including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash, itching, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after receiving this medicine.

Thiotepa can lower the number of white blood cells in your blood temporarily, increasing the chance of getting an infection. It can also lower the number of platelets, which are necessary for proper blood clotting. If this occurs, there are certain precautions you can take, especially when your blood count is low, to reduce the risk of infection or bleeding:

This medicine may cause skin discoloration, itching, blistering or peeling skin in the groin, underarms, skin folds, in the neck, and under dressings. Shower or bathe with water at least two times a day 48 hours after receiving this medicine. Change occlusive dressing and clean the covered skin at least two times a day 48 hours after receiving this medicine. Change bedsheets daily while receiving this medicine. If other skin reactions occur, wash it with water and soap immediately.

Hepatic veno-occlusive disease may occur while you are using this medicine. Tell your doctor right away if you have bloated abdomen or stomach, pain in the upper right abdomen, or yellow skin or eyes after receiving this medicine.

Tell your doctor right away if you have a headache, confusion, dizziness or drowsiness, seizures, problems with memory, or seeing, hearing, or feeling things that are not there after receiving this medicine.

Talk with your doctor before using this medicine if you plan to have children. Some men and women who use this medicine have become infertile (unable to have children).

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Serious side effects of thiotepa

Along with its needed effects, thiotepa may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking thiotepa:

More common side effects

  • bleeding gums
  • blood in the urine
  • blurred or double vision
  • confusion
  • coughing up blood
  • cracked lips
  • diarrhea
  • difficulty with breathing or swallowing
  • difficulty with walking
  • dizziness
  • drooping eyelids
  • headache, sudden, severe
  • increased menstrual flow or vaginal bleeding
  • jaw pain
  • nausea and vomiting
  • nosebleeds
  • numbness or tingling in the fingers and toes
  • pain in the fingers and toes
  • paralysis
  • prolonged bleeding from cuts
  • red or black, tarry stools
  • red or dark brown urine
  • sores, ulcers, or white spots on the lips, tongue, or inside the mouth
  • weakness

Incidence not known

  • absent, missed, or irregular menstrual periods
  • blistering, peeling, or loosening of the skin
  • bloated abdomen
  • cough or hoarseness
  • fast heartbeat
  • fever or chills
  • hives or welts, itching, or skin rash
  • joint or muscle pain
  • lower back or side pain
  • pain and fullness in the right upper abdomen or stomach
  • painful or difficult urination
  • pale skin
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • redness of the skin
  • stopping of menstrual bleeding
  • tightness in the chest
  • troubled breathing with exertion
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • weight gain
  • yellow eyes and skin

Other side effects of thiotepa

Some side effects of thiotepa may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

  • abdominal or stomach pain
  • blistering, burning, crusting, dryness, or flaking of the skin
  • hair loss or thinning of the hair
  • itching, scaling, severe redness, soreness, or swelling of the skin
  • loss of appetite
  • pain at the injection site
  • stopping of menstrual bleeding
  • weight loss

For healthcare professionals

Applies to thiotepa: injectable powder for injection, intravenous powder for injection.

Hematologic adverse events

Granulocytopenia

thromboembolism, venous thromboembolism[Ref]

Oncologic

leukemia[Ref]

Hypersensitivity

Local

Gastrointestinal

Renal

Respiratory

Nervous system

Dermatologic

Genitourinary

Ocular

Other

Immunologic

Musculoskeletal

Metabolic

Psychiatric

Hepatic

Glutamyltransferase, increased blood alkaline, phosphatase increased, aspartate aminotransferase increased[Ref]

Cardiovascular

Endocrine

See also:

References

1. (2001) "Product Information. Thiotepa (thiotepa)." Hikma USA (formerly West-Ward Pharmaceutical Corporation)

2. Cerner Multum, Inc. "Australian Product Information."

Further information

Thiotepa side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.