Phenytoin Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Phenytoin	Humira (adalimumab)	Methotrexate	Enter another drug to compare

Phenytoin

Humira (adalimumab)

Methotrexate

Prescription only

Prescribed for Epilepsy, Seizures, Anxiety, Arrhythmia, Cluster-Tic Syndrome, Neurosurgery, Status Epilepticus, Seizure Prophylaxis During or Following Neurosurgery, Myotonia Congenita, Peripheral... View more

Prescription only

Humira is a TNF-alfa inhibitor that may be used to treat a wide range of different inflammatory conditions, such as Rheumatoid Arthritis, psoriasis, ankylosing spondylitis, Crohn's disease, and... View more

Prescription only

Methotrexate may be considered for the treatment of psoriasis, rheumatoid arthritis, polyarticular juvenile idiopathic arthritis (pJIA), mycosis fungoides, and certain cancers, such as ALL or... View more

More about Phenytoin

More about Humira (adalimumab)

More about Methotrexate

Ratings & Reviews

Phenytoin has an average rating of 7.5 out of 10 from a total of 117 ratings on Drugs.com. 66% of reviewers reported a positive effect, while 15% reported a negative effect.

Humira has an average rating of 6.4 out of 10 from a total of 703 ratings on Drugs.com. 55% of reviewers reported a positive effect, while 30% reported a negative effect.

Methotrexate has an average rating of 6.5 out of 10 from a total of 338 ratings on Drugs.com. 53% of reviewers reported a positive effect, while 24% reported a negative effect.

View all 117 reviews

View all 703 reviews

View all 338 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Dizziness (10.3%)
Rash (7.7%)
Memory loss (6.8%)
Swelling (6.8%)
Seizures (5.1%)
Fever (4.3%)
Drowsiness (3.4%)

View all Phenytoin side effects

Pain (10.7%)
Headaches (4.7%)
Fatigue (4.4%)
Psoriasis (4.4%)
Rash (4.3%)
Tiredness (3.6%)
Itching (3.3%)

View all Humira side effects

Nausea (14.8%)
Tiredness (13.9%)
Fatigue (11.5%)
Hair loss (8.6%)
Pain (6.8%)
Headaches (5.6%)
Loss of appetite (5.0%)

View all Methotrexate side effects

Drug Class

Hydantoin anticonvulsants

Generic Availability

Lower cost generic

N/A

Lower cost generic

Pricing and Coupons * Prices are without insurance

Quantity	200 mL
Strength	25 mg/mL
Per unit^*	$1.46
Cost^*	$291.40

View all Phenytoin prices

Quantity	2 kit
Strength	40 mg/0.8 mL
Per unit^*	$3,700.02
Cost^*	$7,400.03

View all Humira prices

Quantity	20 each
Strength	2.5 mg
Per unit^*	$1.52
Cost^*	$30.31

View all Methotrexate prices

Get free Discount Card

Dosage Forms

Oral suspension
Oral tablet, chewable

Subcutaneous kit

Injectable powder for injection
Injectable solution
Oral tablet

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

15 hours

480 hours

15 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category D Positive evidence of risk

See the full pregnancy warnings document.

Category B No proven risk in humans

See the full pregnancy warnings document.

Category X Not for use in pregnancy

See the full pregnancy warnings document.

Drug Interactions

A total of 861 drugs are known to interact with Phenytoin:

244 major drug interactions (689 brand and generic names)
569 moderate drug interactions (3668 brand and generic names)
46 minor drug interactions (289 brand and generic names)

A total of 555 drugs are known to interact with Humira:

300 major drug interactions (871 brand and generic names)
245 moderate drug interactions (944 brand and generic names)
9 minor drug interactions (37 brand and generic names)

A total of 728 drugs are known to interact with Methotrexate:

145 major drug interactions (668 brand and generic names)
567 moderate drug interactions (2745 brand and generic names)
15 minor drug interactions (47 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Phenytoin levels may decrease when the suspension is given with enteral feedings. This could lead... View more
Using phenytoin together with alcohol may alter the effects of phenytoin. Contact your doctor if... View more

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

Caffeine may reduce the effectiveness of methotrexate in the treatment of arthritis. If you are... View more
Methotrexate may cause liver problems, and using it with other medications that can also affect the... View more

Disease Interactions

First Approval Date

January 06, 1953

December 31, 2002

December 07, 1953

WADA Class View classifications

N/A

More Information

Patient Resources

Phenytoin uses

Humira uses

Methotrexate uses

Professional Resources

Prescribing information

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Phenytoin Alternatives Compared

See also:

Lamictal

Carbamazepine

Entyvio

Levetiracetam

Lyrica

Topiramate

Diazepam

Pregabalin

Lorazepam

Clonazepam

Further information

Phenytoin Alternatives Compared

See also:

Further information

Compare Drugs