Orphengesic Alternatives Compared
| Orphengesic (aspirin / caffeine / orphenadrine) | Cyclobenzaprine | Tizanidine |
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| Orphengesic (aspirin / caffeine / orphenadrine) | Cyclobenzaprine | Tizanidine |
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Prescription only
Prescribed for Muscle Spasm, Muscle Pain. Orphengesic may also be used for purposes not listed in this medication guide. |
Prescription only
Cyclobenzaprine is a muscle relaxant that may be used short-term to treat muscle spasms caused by musculoskeletal conditions, in addition to rest and physical therapy. Sedation is a common side... View more |
Prescription only
Tizanidine may be used to reduce muscle spasms but common side effects include sleepiness, a drop in blood pressure, and a dry mouth. The dosage of tizanidine should be tailored to each person and... View more |
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| More about Orphengesic (aspirin / caffeine / orphenadrine) | More about Cyclobenzaprine | More about Tizanidine | ||||||||||||||||
| Ratings & Reviews | ||||||||||||||||||
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Be the first to share your experience with this drug. |
Cyclobenzaprine has an average rating of 6.0 out of 10 from a total of 619 ratings on Drugs.com. 47% of reviewers reported a positive effect, while 30% reported a negative effect. |
Tizanidine has an average rating of 6.2 out of 10 from a total of 381 ratings on Drugs.com. 48% of reviewers reported a positive effect, while 29% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | ||||||||||||||||||
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View all Orphengesic side effects |
View all Cyclobenzaprine side effects |
View all Tizanidine side effects |
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| Drug Class | ||||||||||||||||||
| Generic Availability | ||||||||||||||||||
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N/A |
Lower cost generic |
Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||
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We could not find an exact match for this medicine. Try searching the Price Guide directly. |
View all Cyclobenzaprine prices |
View all Tizanidine prices |
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| Dosage Forms | ||||||||||||||||||
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N/A |
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| Brand Names | ||||||||||||||||||
| Other aspirin / caffeine / orphenadrine brands include: Norgesic, Orphengesic Forte | Amrix, Comfort Pac with Cyclobenzaprine | Ontralfy, Zanaflex | ||||||||||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | ||||||||||||||||||
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16 hours |
72 hours |
2.5 hours |
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| CSA Schedule 1 View glossary of CSA terms | ||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||
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Category N
Not classified
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Category B
No proven risk in humans
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | ||||||||||||||||||
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A total of 754 drugs are known to interact with Orphengesic:
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A total of 452 drugs are known to interact with Cyclobenzaprine:
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A total of 647 drugs are known to interact with Tizanidine:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||
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| Disease Interactions | ||||||||||||||||||
| First Approval Date | ||||||||||||||||||
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May 29, 1998 |
August 26, 1977 |
November 27, 1996 |
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| WADA Class View classifications | ||||||||||||||||||
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N/A |
N/A |
N/A |
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| More Information | ||||||||||||||||||
| Patient Resources | ||||||||||||||||||
| Professional Resources | ||||||||||||||||||
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N/A |
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| Related Treatment Guide | ||||||||||||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.