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Aspirin, caffeine, and orphenadrine

Generic name: aspirin, caffeine, and orphenadrine [ AS-pir-in, KAF-feen, and-or-FEN-a-dreen ]
Brand names: Norgesic Forte, Orphengesic Forte, Norgesic, Orphengesic
Dosage form: oral tablet (770 mg-60 mg-50 mg)
Drug class: Skeletal muscle relaxant combinations

Medically reviewed by on May 31, 2022. Written by Cerner Multum.

What is aspirin, caffeine, and orphenadrine?

Aspirin, caffeine, and orphenadrine is a combination medicine that is used together with rest and physical therapy to treat painful muscular conditions.

Aspirin, caffeine, and orphenadrine may also be used for purposes not listed in this medication guide.


Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Before taking this medicine

You should not use aspirin, caffeine, and orphenadrine if you are allergic to aspirin, caffeine, or orphenadrine, or if you have:

  • glaucoma;

  • a blockage in your digestive tract (stomach or intestines);

  • a bladder obstruction or other urination problems;

  • an enlarged prostate;

  • myasthenia gravis; or

  • problems with the muscles in your esophagus (the tube that connects your mouth and stomach).

Tell your doctor if you have ever had:

Tell your doctor if you are pregnant or breastfeeding.

Do not give this medicine to anyone with a fever, flu symptoms, or chickenpox. Aspirin can cause Reye's syndrome, a serious and sometimes fatal condition.

Aspirin, caffeine, and orphenadrine is not approved for use by anyone younger than 12 years old.

How should I take aspirin, caffeine, and orphenadrine?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Call your doctor if your symptoms do not improve, or if they get worse.

If you use this medicine long-term, you may need frequent medical tests.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking aspirin, caffeine, and orphenadrine?

Avoid driving or hazardous activity until you know how aspirin, caffeine, and orphenadrine will affect you. Your reactions could be impaired.

Ask a doctor or pharmacist before using other medicines for pain, fever, swelling, or cold/flu symptoms. They may contain aspirin or other salicylates.

Aspirin, caffeine, and orphenadrine side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Aspirin, caffeine, and orphenadrine may cause serious side effects. Call your doctor at once if you have:

  • confusion, anxiety;

  • fast or pounding heartbeats, fluttering in your chest;

  • tremors;

  • little or no urination;

  • eye pain, vision problems; or

  • a light-headed feeling, like you might pass out.

Common side effects of aspirin, caffeine, and orphenadrine may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect aspirin, caffeine, and orphenadrine?

Other drugs may affect aspirin, caffeine, and orphenadrine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.