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Aspirin / Caffeine / Orphenadrine Side Effects

Medically reviewed by Drugs.com. Last updated on May 29, 2024.

Applies to aspirin / caffeine / orphenadrine: oral tablet.

It is very important that your doctor check your or your child's progress, especially if you will be using this medicine for a long time. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to use it. Blood and urine tests may be needed to check for unwanted effects.

Using this medicine during the later part of pregnancy can harm your unborn baby. If you think you have become pregnant while using the medicine, tell your doctor right away.

This medicine contains aspirin, which may cause a condition called Reye's syndrome, especially in children with or recovering from a viral infection (including chicken pox, influenza). Do not give this medicine in these patients, unless ordered by your doctor. Talk to your doctor if you have concerns.

This medicine may cause confusion, tremors, or lightheadedness, or make you less alert than you are normally. Do not drive or do anything else that could be dangerous until you know how this medicine affects you. Sit or lie down if you feel dizzy. Stand up carefully.

Check with your doctor right away if you have black, tarry stools, chest pain, chills, cough, fever, painful or difficult urination, rash, sore throat, sores, ulcers, or white spots on the lips or in the mouth, swelling of the face, swollen glands, trouble breathing, unusual bleeding or bruising, or unusual tiredness or weakness. These may be symptoms of serious skin reaction called drug with eosinophilia with systemic syndrome (DRESS).

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or non-prescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Serious side effects

Along with its needed effects, aspirin / caffeine / orphenadrine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking aspirin / caffeine / orphenadrine:

Less common side effects

  • agitation
  • anxiety
  • confusion
  • fast or irregular breathing
  • irritability
  • nervousness
  • nightmares
  • restlessness
  • seeing, hearing, or feeling things that are not there
  • seizures
  • tremors
  • unusual feeling of excitement

Rare side effects

  • black, tarry stools
  • chest pain or tightness
  • chills
  • cough
  • fever
  • headache
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • swollen or painful glands
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vomiting of blood or material that looks like coffee grounds

Incidence not known

  • decrease in the frequency of urination or urine volume
  • difficulty in passing urine (dribbling)
  • dizziness
  • fainting
  • fast, pounding, or irregular heartbeat or pulse
  • lightheadedness
  • painful urination

Other side effects

Some side effects of aspirin / caffeine / orphenadrine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

  • blurred vision
  • constipation
  • drowsiness
  • dry mouth
  • itching, red, skin rash

See also:

Further information

Aspirin/caffeine/orphenadrine side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.