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Aspirin / caffeine / orphenadrine Side Effects

Applies to aspirin / caffeine / orphenadrine: oral tablet

In addition to its needed effects, some unwanted effects may be caused by aspirin / caffeine / orphenadrine. In the event that any of these side effects do occur, they may require medical attention.

If any of the following symptoms of overdose occur while taking aspirin / caffeine / orphenadrine, get emergency help immediately:

Symptoms of overdose in children
  • Changes in behavior
  • drowsiness or tiredness (severe)
  • fast or deep breathing
  • Any loss of hearing
  • bloody urine
  • confusion
  • convulsions (seizures)
  • diarrhea
  • dizziness or lightheadedness (severe)
  • drowsiness (severe)
  • excitement or nervousness (severe)
  • fast or deep breathing
  • hallucinations (seeing, hearing, or feeling things that are not there)
  • headache (severe or continuing)
  • increased sweating
  • nausea or vomiting (severe or continuing)
  • ringing or buzzing in the ears (continuing)
  • uncontrollable flapping movements of the hands, especially in elderly patients
  • unexplained fever
  • unusual thirst
  • vision problems

Severity: Moderate

If any of the following side effects occur while taking aspirin / caffeine / orphenadrine, check with your doctor or nurse as soon as possible:

Less common or rare:
  • Abdominal or stomach pain, cramping, or burning (severe)
  • bloody or black, tarry stools
  • decreased urination
  • eye pain
  • fainting
  • fast or pounding heartbeat
  • shortness of breath, troubled breathing, tightness in chest, or wheezing
  • skin rash, hives, itching, or redness
  • sores, ulcers, or white spots on lips or in mouth
  • swollen and/or painful glands
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vomiting of blood or material that looks like coffee grounds

Minor Side Effects

Some of the side effects that can occur with aspirin / caffeine / orphenadrine may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Abdominal or stomach cramps, pain, or discomfort (mild to moderate)
  • dryness of mouth
  • heartburn or indigestion
  • nausea or vomiting (mild)
Less common:
  • Blurred or double vision or other vision problems
  • confusion
  • constipation
  • difficult urination
  • dizziness or lightheadedness
  • drowsiness
  • excitement, nervousness, or restlessness
  • headache
  • muscle weakness
  • trembling
  • unusually large pupils of eyes

Not all side effects for aspirin / caffeine / orphenadrine may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.