Methylphenidate Alternatives Compared
| Methylphenidate | Vyvanse | Adderall |
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| Methylphenidate | Vyvanse lisdexamfetamine | Adderall amphetamine / dextroamphetamine |
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Methylphenidate improves symptoms of ADHD but carries with it a risk of dependence and side effects such as insomnia are common. To avoid insomnia the last dose should be administered before 6pm... View more |
Vyvanse is a stimulant used for the treatment of ADHD to reduce symptoms such as impulsiveness and hyperactivity and to increase attention. It can also help increase the number of binge-free days per... View more |
Adderall is a combination of four different amphetamine salts and may be used to improve attention, focus, or reduce impulsive behaviors in children over the age of 3 and adults with ADHD. It can... View more |
Choose a suggestion below ADHD (Attention Deficit Hyperactivity Disorder)
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| More about Methylphenidate | More about Vyvanse (lisdexamfetamine) | More about Adderall (amphetamine / dextroamphetamine) | ||||||||||||||||||||||||
| Generic Status | ||||||||||||||||||||||||||
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No lower-cost generic available |
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| Availability | ||||||||||||||||||||||||||
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Prescription only |
Prescription only |
Prescription only |
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| Ratings & Reviews | ||||||||||||||||||||||||||
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Methylphenidate has an average rating of 7.2 out of 10 from a total of 949 ratings on Drugs.com. 61% of reviewers reported a positive effect, while 17% reported a negative effect. |
Vyvanse has an average rating of 7.4 out of 10 from a total of 871 ratings on Drugs.com. 65% of reviewers reported a positive effect, while 15% reported a negative effect. |
Adderall has an average rating of 7.7 out of 10 from a total of 406 ratings on Drugs.com. 69% of reviewers reported a positive effect, while 13% reported a negative effect. |
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| Drug Class | ||||||||||||||||||||||||||
| Side Effects | ||||||||||||||||||||||||||
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Commonly reported side effects include: insomnia, nausea, headache, vomiting, decreased appetite, xerostomia. See the full methylphenidate side effects document. |
Common side effects include: insomnia, irritability. See the full Vyvanse side effects document. |
See the full Adderall side effects document. |
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| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||||||||||
View all methylphenidate prices |
View all Vyvanse prices |
View all Adderall prices and generic prices |
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| Dosage Form(s) Available | ||||||||||||||||||||||||||
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| Brand Names | ||||||||||||||||||||||||||
| Adhansia XR, Aptensio XR, Concerta, Cotempla XR-ODT, Daytrana, Jornay PM, Metadate CD, Methylin, Methylin ER, QuilliChew ER, Quillivant XR, Relexxii, Ritalin, Ritalin LA View more |
N/A |
Other amphetamine / dextroamphetamine brands include: Adderall XR, Mydayis | ||||||||||||||||||||||||
| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | ||||||||||||||||||||||||||
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4 hours |
1 hour |
34 hours |
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| CSA Schedule** View glossary of terms | ||||||||||||||||||||||||||
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High potential for abuse
Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence. |
High potential for abuse
Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence. |
High potential for abuse
Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence. |
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| Pregnancy Category | ||||||||||||||||||||||||||
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Category C
Risk cannot be ruled out
See the full Pregnancy Warnings document. |
Category C
Risk cannot be ruled out
See the full Pregnancy Warnings document. |
Category C
Risk cannot be ruled out
See the full Pregnancy Warnings document. |
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| Drug Interactions | ||||||||||||||||||||||||||
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A total of 184 drugs are known to interact with methylphenidate:
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A total of 335 drugs are known to interact with Vyvanse:
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A total of 180 drugs are known to interact with Adderall:
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| First Approval Date | ||||||||||||||||||||||||||
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December 05, 1955 |
February 23, 2007 |
January 19, 1960 |
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| WADA Class View World Anti-Doping Agency classifications. | ||||||||||||||||||||||||||
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N/A |
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| More Information | ||||||||||||||||||||||||||
| Patient resources | ||||||||||||||||||||||||||
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| Related Treatment Guide | ||||||||||||||||||||||||||
** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.