Comparing Methotrexate vs Stelara

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
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Methotrexate

Stelara ustekinumab

Methotrexate may be considered for the treatment of psoriasis or rheumatoid arthritis if other treatments have failed. It may also be used in certain cancers. Side effects can be severe and... View more

Stelara is an immunosuppressant medication that works by binding to two inflammatory cytokines, IL-12 and IL-23, which have been identified as important contributors to chronic inflammation. Stelara... View more

Prescription only

Ratings & Reviews

View all 262 reviews

View all 209 reviews

Drug Class

Interleukin inhibitors

Side Effects

Commonly reported side effects include: increased liver enzymes.

See the full methotrexate side effects document.

See the full Stelara side effects document.

Pricing and Coupons

* Prices are without insurance

Quantity	20 each
Dosage	2.5 mg
Per Unit^*	$2.69
Cost^*	$53.89

View all methotrexate prices

Quantity	0.5 mL
Dosage	45 mg/0.5 mL
Per Unit^*	$25,274.22
Cost^*	$12,637.11

View all Stelara prices

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Generic Availability

Yes (this medicine)

Dosage Form(s) Available

Injectable powder for injection
Injectable solution
Oral tablet

Intravenous solution
Subcutaneous solution

Brand Names

Methotrexate LPF Sodium, Otrexup, Rasuvo, RediTrex, Trexall, Xatmep

N/A

Half Life

The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

12 hours

1291.2 hours

CSA Schedule**

View glossary of terms.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category X Not for use in pregnancy

See the full Pregnancy Warnings document.

Category B No proven risk in humans

See the full Pregnancy Warnings document.

Drug Interactions

A total of 616 drugs are known to interact with methotrexate:

123 major drug interactions (602 brand and generic names)
477 moderate drug interactions (2493 brand and generic names)
16 minor drug interactions (49 brand and generic names)

A total of 385 drugs are known to interact with Stelara:

36 major drug interactions (95 brand and generic names)
342 moderate drug interactions (1166 brand and generic names)
7 minor drug interactions (33 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Caffeine may reduce the effectiveness of methotrexate in the treatment of arthritis. If you are... View more
Methotrexate may cause liver problems, and using it with other medications that can also affect the... View more

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

Disease Interactions

First Approval Date

December 07, 1953

September 25, 2009

WADA Class

View World Anti-Doping Agency classifications.

N/A

More Information

Patient resources

Overview

Professional Resources

Prescribing Information

Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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