Isotretinoin Alternatives Compared
| Isotretinoin | Yervoy | Mekinist |
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| Isotretinoin | Yervoy (ipilimumab) | Mekinist (trametinib) |
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Prescription only
Prescribed for Acne, Rosacea, Acute Nonlymphocytic Leukemia, Granuloma Annulare, Melanoma - Metastatic, Pityriasis rubra pilaris. isotretinoin may also be used for purposes not listed in this medication guide. View more |
Prescription only
Prescribed for Melanoma - Metastatic, Melanoma, Colorectal Cancer, Renal Cell Carcinoma, Malignant Pleural Mesothelioma. Yervoy may also be used for purposes not listed in this medication guide. |
Prescription only
Prescribed for Melanoma - Metastatic, Non-Small Cell Lung Cancer, Solid Tumors, Thyroid Cancer, Low-Grade Glioma. Mekinist may also be used for purposes not listed in this medication guide. |
Related suggestions Melanoma, Metastatic
Popular comparisons
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| More about Isotretinoin | More about Yervoy (ipilimumab) | More about Mekinist (trametinib) | ||||||||||||||||||||||||
| Generic Status | ||||||||||||||||||||||||||
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No lower-cost generic available |
No lower-cost generic available |
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| Ratings & Reviews | ||||||||||||||||||||||||||
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Isotretinoin has an average rating of 8.0 out of 10 from a total of 1053 ratings on Drugs.com. 74% of reviewers reported a positive effect, while 13% reported a negative effect. |
Yervoy has an average rating of 9.5 out of 10 from a total of 2 ratings on Drugs.com. 100% of reviewers reported a positive effect, while 0% reported a negative effect. |
Mekinist has an average rating of 7.3 out of 10 from a total of 3 ratings on Drugs.com. 67% of reviewers reported a positive effect, while 33% reported a negative effect. |
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| Drug Class | ||||||||||||||||||||||||||
| Side Effects | ||||||||||||||||||||||||||
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See also: isotretinoin side effects in more detail. |
See also: Yervoy side effects in more detail. |
See also: Mekinist side effects in more detail. |
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| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||||||||||
View all isotretinoin prices |
View all Yervoy prices |
View all Mekinist prices |
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| Dosage Form(s) Available | ||||||||||||||||||||||||||
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| Brand Names | ||||||||||||||||||||||||||
| Absorica, Absorica LD, Accutane, Amnesteem, Claravis, Myorisan, Sotret, Zenatane |
N/A |
N/A |
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| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | ||||||||||||||||||||||||||
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32 hours |
352.8 hours |
115.2 hours |
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| CSA Schedule ** View glossary of terms | ||||||||||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||||||||||
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Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category D
Positive evidence of risk
See the full pregnancy warnings document. |
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| Drug Interactions | ||||||||||||||||||||||||||
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A total of 125 drugs are known to interact with isotretinoin:
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A total of 150 drugs are known to interact with Yervoy:
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A total of 19 drugs are known to interact with Mekinist:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | ||||||||||||||||||||||||||
| First Approval Date | ||||||||||||||||||||||||||
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May 07, 1982 |
March 25, 2011 |
May 29, 2013 |
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| WADA Class View World Anti-Doping Agency classifications. | ||||||||||||||||||||||||||
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N/A |
N/A |
N/A |
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| Related Treatment Guide | ||||||||||||||||||||||||||
** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.