Comparing Isotretinoin vs Methotrexate
Isotretinoin | Methotrexate |
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Isotretinoin | Methotrexate |
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Prescription only
Prescribed for Acne, Rosacea, Acute Nonlymphocytic Leukemia, Granuloma Annulare, Pityriasis rubra pilaris, Melanoma - Metastatic. Isotretinoin may also be used for purposes not listed in this medication guide. View more |
Prescription only
Methotrexate may be considered for the treatment of psoriasis, rheumatoid arthritis, polyarticular juvenile idiopathic arthritis (pJIA), mycosis fungoides, and certain cancers, such as ALL or... View more |
Related suggestions Pityriasis rubra pilaris
Acute Nonlymphocytic Leukemia
Popular comparisons
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More about Isotretinoin | More about Methotrexate | ||||||||||||||||
Ratings & Reviews | |||||||||||||||||
Isotretinoin has an average rating of 7.9 out of 10 from a total of 1060 ratings on Drugs.com. 73% of reviewers reported a positive effect, while 13% reported a negative effect. |
Methotrexate has an average rating of 6.5 out of 10 from a total of 338 ratings on Drugs.com. 53% of reviewers reported a positive effect, while 24% reported a negative effect. |
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Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||||||||||
View all Isotretinoin side effects |
View all Methotrexate side effects |
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Drug Class | |||||||||||||||||
Generic Availability | |||||||||||||||||
Lower cost generic |
Lower cost generic |
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Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Isotretinoin prices |
View all Methotrexate prices |
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Dosage Forms | |||||||||||||||||
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Brand Names | |||||||||||||||||
Absorica, Absorica LD, Accutane, Amnesteem, Claravis, Myorisan, Sotret, Zenatane | Jylamvo, Methotrexate LPF Sodium, Otrexup, Rasuvo, Trexall, Xatmep | ||||||||||||||||
Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||||||||||
32 hours |
15 hours |
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CSA Schedule 1 View glossary of CSA terms | |||||||||||||||||
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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Pregnancy Category | |||||||||||||||||
Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
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Drug Interactions | |||||||||||||||||
A total of 142 drugs are known to interact with Isotretinoin:
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A total of 728 drugs are known to interact with Methotrexate:
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Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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Disease Interactions | |||||||||||||||||
First Approval Date | |||||||||||||||||
May 07, 1982 |
December 07, 1953 |
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WADA Class View classifications | |||||||||||||||||
N/A |
N/A |
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More Information | |||||||||||||||||
Patient Resources | |||||||||||||||||
Professional Resources | |||||||||||||||||
Related Treatment Guide | |||||||||||||||||
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1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.