Comparing Isotretinoin vs Methotrexate
| Isotretinoin | Methotrexate |
|
|---|
| Isotretinoin | Methotrexate |
|
|||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Prescription only
Prescribed for Rosacea, Acne, Granuloma Annulare, Acute Nonlymphocytic Leukemia, Pityriasis rubra pilaris, Melanoma - Metastatic. Isotretinoin may also be used for purposes not listed in this medication guide. View more |
Prescription only
Methotrexate may be considered for the treatment of psoriasis, rheumatoid arthritis, polyarticular juvenile idiopathic arthritis (pJIA), mycosis fungoides, and certain cancers, such as ALL or... View more |
Related suggestions Pityriasis rubra pilaris
Acute Nonlymphocytic Leukemia
Popular comparisons
|
|||||||||||||||
| More about Isotretinoin | More about Methotrexate | ||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
|
Isotretinoin has an average rating of 7.9 out of 10 from a total of 1060 ratings on Drugs.com. 73% of reviewers reported a positive effect, while 13% reported a negative effect. |
Methotrexate has an average rating of 6.5 out of 10 from a total of 336 ratings on Drugs.com. 52% of reviewers reported a positive effect, while 24% reported a negative effect. |
||||||||||||||||
| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||||||||||
View all Isotretinoin side effects |
View all Methotrexate side effects |
||||||||||||||||
| Drug Class | |||||||||||||||||
| Generic Availability | |||||||||||||||||
|
Lower cost generic |
Lower cost generic |
||||||||||||||||
| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Isotretinoin prices |
View all Methotrexate prices |
||||||||||||||||
| Dosage Forms | |||||||||||||||||
|
|
||||||||||||||||
| Brand Names | |||||||||||||||||
| Absorica, Absorica LD, Accutane, Amnesteem, Claravis, Myorisan, Sotret, Zenatane | Jylamvo, Methotrexate LPF Sodium, Otrexup, Rasuvo, Trexall, Xatmep | ||||||||||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||||||||||
|
32 hours |
15 hours |
||||||||||||||||
| CSA Schedule 1 View glossary of CSA terms | |||||||||||||||||
|
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
||||||||||||||||
| Pregnancy Category | |||||||||||||||||
|
Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
||||||||||||||||
| Drug Interactions | |||||||||||||||||
|
A total of 142 drugs are known to interact with Isotretinoin:
|
A total of 723 drugs are known to interact with Methotrexate:
|
||||||||||||||||
| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
|
|||||||||||||||||
| Disease Interactions | |||||||||||||||||
| First Approval Date | |||||||||||||||||
|
May 07, 1982 |
December 07, 1953 |
||||||||||||||||
| WADA Class View classifications | |||||||||||||||||
|
N/A |
N/A |
||||||||||||||||
| More Information | |||||||||||||||||
| Patient Resources | |||||||||||||||||
| Professional Resources | |||||||||||||||||
| Related Treatment Guide | |||||||||||||||||
|
|||||||||||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
See also:
Accutane
Accutane (isotretinoin) is a form of vitamin A and is used to treat severe nodular acne. Includes ...
Sprintec
Sprintec is used for abnormal uterine bleeding, birth control, endometriosis, gonadotropin ...
Botox
Botox is used for cosmetic purposes and to treat overactive bladder symptoms, urinary incontinence ...
Yaz
Yaz (drospirenone and ethinyl estradiol) is used as a contraceptive to prevent pregnancy. Includes ...
Vibramycin
Vibramycin is used for acne, actinomycosis, amebiasis, anthrax, anthrax prophylaxis, bacterial ...
Lo Loestrin Fe
Lo Loestrin Fe (ethinyl estradiol and norethindrone acetate) birth control tablets are used to ...
Yasmin
Yasmin (drospirenone and ethinyl estradiol) is used as contraception to prevent pregnancy. Includes ...
Ocella
Ocella is used for acne, birth control, premenstrual dysphoric disorder
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.