Fluoxetine Alternatives Compared
| Fluoxetine | Cymbalta | Bupropion |
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| Fluoxetine | Cymbalta duloxetine | Bupropion |
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Fluoxetine may be used for the treatment of depression and other mood disorders. It is more likely to cause insomnia than drowsiness. Prescribed for Anxiety and Stress, Major Depressive Disorder... View more |
Cymbalta has antidepressant, anti-anxiety, and pain-relieving properties; however, it has been associated with a discontinuation syndrome on withdrawal even when tapered. Prescribed for Back Pain... View more |
Bupropion may be used in the treatment of depression or as an aid to smoking cessation; however, side effects may include insomnia, neuropsychiatric adverse events, or seizures. It carries a black... View more |
Choose a suggestion below Depression
Major Depressive Disorder
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| More about Fluoxetine | More about Cymbalta (duloxetine) | More about Bupropion | ||||||||||||||||||||||||
| Generic Status | ||||||||||||||||||||||||||
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Prescription only |
Prescription only |
Prescription only |
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| Ratings & Reviews | ||||||||||||||||||||||||||
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Fluoxetine has an average rating of 7.3 out of 10 from a total of 1996 ratings on Drugs.com. 66% of reviewers reported a positive effect, while 18% reported a negative effect. |
Cymbalta has an average rating of 6.3 out of 10 from a total of 1655 ratings on Drugs.com. 53% of reviewers reported a positive effect, while 30% reported a negative effect. |
Bupropion has an average rating of 7.0 out of 10 from a total of 2560 ratings on Drugs.com. 61% of reviewers reported a positive effect, while 20% reported a negative effect. |
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| Drug Class | ||||||||||||||||||||||||||
| Side Effects | ||||||||||||||||||||||||||
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See the full fluoxetine side effects document. |
Common side effects include: asthenia, constipation, diarrhea, dizziness, drowsiness, fatigue, hypersomnia, insomnia, nausea, sedated state, headache, xerostomia. See the full Cymbalta side effects document. |
Commonly reported side effects include: insomnia, nausea, pharyngitis, weight loss, constipation, dizziness, headache, xerostomia. See the full bupropion side effects document. |
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| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||||||||||
View all fluoxetine prices |
View all Cymbalta prices and generic prices |
View all bupropion prices |
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| Dosage Form(s) Available | ||||||||||||||||||||||||||
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| Brand Names | ||||||||||||||||||||||||||
| Prozac | Other duloxetine brands include: Drizalma Sprinkle, Irenka | Aplenzin, Budeprion, Budeprion SR, Forfivo XL, Wellbutrin SR, Wellbutrin XL | ||||||||||||||||||||||||
| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | ||||||||||||||||||||||||||
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210 hours |
17 hours |
30 hours |
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| CSA Schedule** View glossary of terms | ||||||||||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||||||||||
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Category C
Risk cannot be ruled out
See the full Pregnancy Warnings document. |
Category C
Risk cannot be ruled out
See the full Pregnancy Warnings document. |
Category C
Risk cannot be ruled out
See the full Pregnancy Warnings document. |
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| Drug Interactions | ||||||||||||||||||||||||||
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A total of 648 drugs are known to interact with fluoxetine:
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A total of 573 drugs are known to interact with Cymbalta:
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A total of 425 drugs are known to interact with bupropion:
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| First Approval Date | ||||||||||||||||||||||||||
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December 29, 1987 |
N/A |
December 30, 1985 |
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| WADA Class View World Anti-Doping Agency classifications. | ||||||||||||||||||||||||||
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N/A |
N/A |
N/A |
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| Related Treatment Guide | ||||||||||||||||||||||||||
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** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.