Estradiol topical Alternatives Compared
| Estradiol topical | Gemtesa (vibegron) | Botox (onabotulinumtoxinA) |
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| Estradiol topical | Gemtesa (vibegron) | Botox (onabotulinumtoxinA) |
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Prescription only
Prescribed for Atrophic Vaginitis, Atrophic Urethritis, Overactive Bladder, Dyspareunia. Estradiol topical may also be used for purposes not listed in this medication guide. |
Prescription only
Prescribed for Overactive Bladder. Gemtesa may also be used for purposes not listed in this medication guide. |
Prescription only
Botox is approved to treat many conditions, such as chronic migraine, involuntary muscle contractions or twitching, excessive sweating, increased saliva, and overactive bladder to name a few. Botox... View more |
Related suggestions Overactive Bladder
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| More about Estradiol topical | More about Gemtesa (vibegron) | More about Botox (onabotulinumtoxinA) | ||||||||||||||||||||||||
| Ratings & Reviews | ||||||||||||||||||||||||||
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Estradiol topical has an average rating of 5.1 out of 10 from a total of 491 ratings on Drugs.com. 37% of reviewers reported a positive effect, while 45% reported a negative effect. |
Gemtesa has an average rating of 7.7 out of 10 from a total of 207 ratings on Drugs.com. 69% of reviewers reported a positive effect, while 12% reported a negative effect. |
Botox has an average rating of 5.7 out of 10 from a total of 481 ratings on Drugs.com. 47% of reviewers reported a positive effect, while 41% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | ||||||||||||||||||||||||||
View all Estradiol topical side effects |
View all Gemtesa side effects |
View all Botox side effects |
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| Drug Class | ||||||||||||||||||||||||||
| Generic Availability | ||||||||||||||||||||||||||
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Lower cost generic |
N/A |
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| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||||||||||
View all Estradiol topical prices |
View all Gemtesa prices |
View all Botox prices |
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| Dosage Forms | ||||||||||||||||||||||||||
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| Brand Names | ||||||||||||||||||||||||||
| Estrace Vaginal Cream, Estring, Imvexxy, Vagifem, Yuvafem |
N/A |
Other onabotulinumtoxinA brands include: Botox Cosmetic | ||||||||||||||||||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | ||||||||||||||||||||||||||
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N/A |
94 hours |
N/A |
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| CSA Schedule 1 View glossary of CSA terms | ||||||||||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||||||||||
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Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
Summary unavailable. See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | ||||||||||||||||||||||||||
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A total of 260 drugs are known to interact with Estradiol topical:
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A total of 148 drugs are known to interact with Gemtesa:
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A total of 120 drugs are known to interact with Botox:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | ||||||||||||||||||||||||||
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| First Approval Date | ||||||||||||||||||||||||||
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January 31, 1984 |
December 23, 2020 |
December 09, 1991 |
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| WADA Class View classifications | ||||||||||||||||||||||||||
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N/A |
N/A |
N/A |
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| More Information | ||||||||||||||||||||||||||
| Patient Resources | ||||||||||||||||||||||||||
| Professional Resources | ||||||||||||||||||||||||||
| Related Treatment Guide | ||||||||||||||||||||||||||
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1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
See also:
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.