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User Reviews for Estradiol topical

Also known as: Vagifem, Estrace Vaginal Cream, Yuvafem, Estring, Imvexxy

Estradiol topical has an average rating of 5.0 out of 10 from a total of 385 ratings on Drugs.com. 38% of those users who reviewed Estradiol topical reported a positive effect, while 45% reported a negative effect.

Condition Avg. Rating Reviews Compare
Atrophic Vaginitis  
4.9
340 reviews 54 medications
Atrophic Urethritis  
6.0
31 reviews 46 medications
Dyspareunia  
4.6
14 reviews 3 medications
Summary of Estradiol topical reviews 5.0 385 reviews

Reviews may be moderated or edited before publication to correct grammar and spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest in the medication will not be published. As reviews and ratings are subjective and self-reported, this information should not be used as the basis for any statistical analysis or scientific studies.

Reviews for Estradiol topical

domino606 · Taken for 1 to 6 months June 21, 2021

Yuvafem (estradiol) for Atrophic Vaginitis: “In the beginning I had repeated UTI's. One dr suggested it might be menopause systems. I went to the gynecologist and she gave me Imvexxy first. It did not help. I still had the terrible burning, so she switched me to the Yuvafem. I've been taking it for a couple of months now. I don't really like the applicator, it hurts. If you use lubricant it will go in easier. sometimes I have no symptoms at all. But for what ever reason they will come back, not as bad but its there. I have to use replens moisturizer on those days. I never tried the other, my insurance will only pay for the Yuvafem even though I was written a script for the name brand and not Yuvafem. I have not had any joint pain or discharge. If the insert is not inserted all the way up to plunger that you push in ,the pill will come out. I only had the pill fall out once. I knew I had not put it all the way in. So far that is the only one I have found.”

8 / 10
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Lola F · Taken for 1 to 6 months May 9, 2021

Vagifem (estradiol) for Atrophic Vaginitis: “I've been using vagifem for a few months now & definitely took several weeks for my symptoms to calm down. Before using this my entire vaginal area had become dry, hyper sensitive & sore & sex was so painful, vagifem has restored lubrication & feel like me again, so happy with results. Also have had no hot flashes since I started taking it & these were happening multiple times a night also not had a UTI since & have been having them every couple of months most of my adult life.”

10 / 10
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Chads · Taken for 5 to 10 years May 7, 2021

Vagifem (estradiol) for Atrophic Vaginitis: “I have been using Vagifem for many years now and although it's helped my symptoms a great deal, I find the recommended dosage of 1 pessary twice a week is not enough to keep me comfortable, however my dr refuses to prescribe me any extra. Imagine my surprise on visiting the Menopause Matters site to find many women on there are prescribed it 5x a week as twice a week doesn't relieve their symptoms. Apparently each Vagifem pessary used to be 25mcg (=50mcg a week) but for some unknown reason they reduced it to 10mcg per pessary (=20mcg a week)”

7 / 10
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Ellie · Taken for 2 to 5 years September 21, 2020

Estrace Vaginal Cream (estradiol) for Atrophic Vaginitis: “Horrible itching, burning, swelling from any topical estrogen I tried - estrace, vagifem, premarin. After 3 years of suffering, all with normal cultures (no infection), I insisted on biopsy of vulva - showed probable hypersensitivity reaction from allergy!!! Stopped all estrogens, but atrophic vaginitis returned with different burning and dryness, and painful sex. Then researched and found out that topical estrogens can cause all my symptoms from allergic reaction to the preservatives and other ingredients! My gyn had no clue. I researched this, and told doctor to order Estriol cream in VERSABASE cream base - versabase is hypoallergenic. I AM CURED - the compounded estriol in versabase has fixed my atrophic vaginitis without allergic reaction. I have my vagina back! Find a compounding pharmacy - I use estriol 1 mg/gram compounded - daily x 2 weeks then twice a week. Call around as the different compounding pharmacies have huge price differences for the same compound. Good luck!!!!”

1 / 10
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Jlady May 28, 2013

Estrace Vaginal Cream (estradiol) for Atrophic Vaginitis: “I'm 71 years old. The tearing and associated pain started a few months ago. Just hoped it would go away but it did not. I would not let my husband touch me. Spoke with 2 doctors I know and they said its normal but Estrace would help. It did. My prescription is dated 3/7/2013. Within 10 days the tearing stopped and all was healed. Use 1 gram 3 X a week. Nothing bad has happened. My libido near immediately was through the roof. I am amazed and nobody needs to try and take this medicine away from me! I'm loving it and my husband is happy too. Yes, my age up there is right.”

10 / 10
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Pookie · Taken for 10 years or more March 10, 2020

Vagifem (estradiol) for Atrophic Vaginitis: “Does anyone know if any of the ingredients have changed recently? I have been using vagifem for almost 15 years once a week and never experienced any burning but recently out of the blue I have burning and cannot understand why as I am using the brand and not the generic as that caused horrible problems. It works great but not happy with the irritation. Thank you.”

8 / 10
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Gal · Taken for 1 to 2 years September 17, 2020

Vagifem (estradiol) for Atrophic Vaginitis: “I left a comment in August regarding Vagifem and gave it 10/10 for curing my symptoms of repeated urinary tract infections but over the last few weeks since starting a new box of Vagifem I have noticed that for the first 2 days after using it I too am getting a stinging feeling in the vagina which also makes me feel like I have a urinary tract infection and tingling in the breasts which I have not experienced before. Reluctantly I have stopped the medication as these new symptoms are too uncomfortable and I am wondering if the manufacturer has changed the formula. Not happy.”

7 / 10
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letmepost654 · Taken for 5 to 10 years July 16, 2013

Estrace Vaginal Cream (estradiol) for Atrophic Vaginitis: “I'm 65 and had ovaries removed 11 years ago, along with uterus and cervix. Since that, I have almost no sex drive and intercourse was super painful. Estrace vaginal cream really helps, and I only have to use a pea sized dab every other day. Just using a finger to apply at bedtime works great. It seems to me that the dire warnings about using estrogens is misleading since no studies have been done on just vaginal estradiol rather than on oral estrogen, and much higher doses are still prescribed than are needed for maintenance. Without Estrace vaginal cream, intercourse would be impossible and husband would be very unhappy. ”

10 / 10
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twistedK · Taken for less than 1 month January 23, 2016

Estrace Vaginal Cream (estradiol) for Atrophic Vaginitis: “So - I was prescribed this and was shocked when I went to the pharmacy and she said $135. Dr. never mentioned this. I said "doesn't my insurance pay anything on this?" She checked and said "It's normally $350.00" or something. I was really angry. Angry, embarassed and this whole experience is humiliating to women. Why do I think a prescription of Viagra has a co-pay of like $10?? IT'S TIME TO STOP DISCRIMINATING AGAINST WOMEN. Especially us older women!!! That is ridiculous!!! I did not buy it, I was so angry. I may.... but I doubt it. I was prescribed this with an oral progesterone -- any one have experience with these two items combined? Thanks for letting me air that - take heed, Big Pharma.”

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Wonder woman · Taken for less than 1 month March 18, 2021

Vagifem (estradiol) for Atrophic Vaginitis: “I was prescribed Vagifem finally after a year of burning, painful sex and constant urine infections. Literally after 3 days the burning was 70% better and I actually enjoyed sex for the first time in ages ! Totally recommend Vagifem and I've had zero side affects . Still got every other peri menopause symptom but one less to deal with is a huge relief! Good luck ladies !”

9 / 10
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M · Taken for less than 1 month April 12, 2021

Vagifem (estradiol) for Atrophic Vaginitis: “Worst 'medication' I've ever had. Horrific headache, couldn't even get up out of bed safely the day after one and only application, extreme nausea and dizziness, next few days spotting, vaginal pain, burning for the next two weeks until I took some acid regulators. Subsequently have been sleepless, extremely low on energy, cystitis, cold sore - basically everything saying the body's taken a beating. One pessary. Still battling it four weeks later. Never again.”

1 / 10
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Lou · Taken for 1 to 6 months February 9, 2021

Vagifem (estradiol) for Atrophic Urethritis: “I am 43 and was sceptical about using Vagifem as did not have vagina dryness which is what it says it’s for, but I have had problems with ongoing leaking bladder since giving birth to very large baby and most recently consistent UTI . All I can say is thank goodness the female doctor I had told me to try this. I have not had any urine leakage at all since I been on it which is a miracle and no bladder infections. There so many women my age with this trouble it should be prescribed more for this it’s so good amazing !”

10 / 10
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calinative · Taken for 6 months to 1 year November 17, 2020

Imvexxy (estradiol) for Dyspareunia: “I have been using Imvexxy for 6 months. I use the 10mcg one time per week. I would be fine using the 4 mcg twice per week, but it is easier to use the 10 mcg once per week. One minor side effect I noticed is that sometimes I get a slight pelvic cramping a couple of hours after I insert it. It usually does not last more than a few minutes. Other than that, so far it is working for me. I am finally able to resume intercourse with no issues. Everything feels like it was before menopause. I spent a lot of money on the Mona Lisa touch prior to using Imvexxy and it did not work at all.”

9 / 10
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Lily · Taken for 10 years or more April 1, 2021

Vagifem (estradiol) for Atrophic Urethritis: “I am 80 years old and I've been taking Vagifem for over 15 years since my surgery (Radical historectomy for uterine cancer). I trusted my doctor completely and have not had any problems with UTI's or vaginal dryness. I also use a KY-gel product after my shower and have no problem reaching a climax with masturbation, my only sexual release at my age. I also get Vagifem from Canadian Pharmacy for one-third the cost in the States. My younger sister could not tolerate Vagifem for many of the negative reports here, but she also didn't have cancer and is able to get relief from other meds. I really appreciate your comments and wish all the best to my sisters-at-large.”

10 / 10
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Sara55 · Taken for less than 1 month December 30, 2019

Estrace Vaginal Cream (estradiol) for Atrophic Vaginitis: “I was using Estrace and was doing very well. Then they approved the generic Estradiol. I can already tell the difference. I’m itching and sex is painful again. Estrace is too expensive now that the generic has been released. Also Allergen offered free applicators but Mylan won’t even answer an e- mail regarding this. I think it VERY unsanitary to expect one to reuse the tubes. Allergen won’t even respond when I asked if I could buy the applicators for the generic- I did find them on Amazon for $33 a bag. Thinking about paying full price for the Estrace to get the free applicator program again. I’m going to try this generic a few more times. If I don’t see improvement and still have issues, I’m stopping it and reporting it to the FDA. Does anyone else have problems with generic but was doing great on Estrace brand??”

8 / 10
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whims · Taken for 2 to 5 years January 6, 2021

Imvexxy (estradiol) for Atrophic Vaginitis: “I'm 65 years old I started Imvexxy when I turned 62 and it worked for me I thought life was great again then I turned 65 and Medicare/Blue Cross entered my life the price is over 200 dollars a month for me and of coarse my insurances will not cover that at all so it is out of my pocket ! I had to turn to a different brand this brand does not work for me sad to say . Why would Imvexxy get you hooked and then once you really need at our age and you cant afford it !!!!!”

8 / 10
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sammie · Taken for less than 1 month April 3, 2020

Vagifem (estradiol) for Atrophic Vaginitis: “I tried Vagifem for two weeks and while I think it probably helped with soreness inside and plumped things up, it also caused irritation of the uretha whereby I had a constant pressure, feeling like a need to wee all the time, burning and stinging inside. I couldn't live with it and it kept on waking me up at night. These symptoms started when I used vagifem and stopped when I stopped it. I really hope there is an alternative as I think for many vagifem is a miracle.”

5 / 10
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Gram · Taken for 1 to 6 months June 6, 2019

Estrace Vaginal Cream (estradiol) for Atrophic Vaginitis: “I am 71 years old and my doctor prescribed estradiol for vaginal atrophy. I was reluctant to try it but my symptoms worsened so I started the estradiol 3 times a week. After a few weeks I was symptom-free and feeling great. However after 3 months my symptoms gradually returned and now I have burning all day and the urination urgency off and on during the day. My symptoms abate at night. My doctor doesn’t have any answers as to why the medication stopped working. Does anyone else have this problem and what was your solution.?”

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Mojo · Taken for less than 1 month February 7, 2020

Vagifem (estradiol) for Atrophic Urethritis: “Have been having very painful cystitis and UTI's for over 4 years, I have been given numerous antibiotics over this time, after 1 to 2 weeks of finishing the course it was back again, was then kept on antibiotics full time, the specialist then suggested vagifem, the first one did sting, so didn't take more, then tried again 3 weeks later, and the pain & inflammation started to ease, after 4 Yr & antibiotics that didn't work I had found a breakthrough med, cannot believe at 57-62 age the GP never thought lack of estrogen could be the cause.”

10 / 10
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Lea · Taken for 6 months to 1 year November 13, 2020

Imvexxy (estradiol) for Atrophic Vaginitis: “I have been taking Imvexxy 10mg twice a week for about 10 months now. I had dryness on the outside of my personal area, more so then the inside dryness. I'm 64 with a healthy sex life. My husband thought it made me too lubricated and he didn't care for it. After two months I noticed night sweats, and some hair loss along with slight headaches. Mostly the night sweats was my big problem. I adjusted to 1 time a week of the 10mcg for a month, but still had night sweats. Now, I have been totally off Imvexxy for two weeks and noticed the night sweats have lightened up a bit. I am going to continue to stay off for 6 weeks to see if there is a big difference with the night sweats, hoping they disappear completely. I did not have this problem before I was on Imvexxy. The reason I was checking out these reviews was to see if anyone else had these same side effects, please let me know if you do.”

8 / 10
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Sexpert March 30, 2016

Estrace Vaginal Cream (estradiol) for Atrophic Vaginitis: “Very sexually active until severe abrupt menopausal symptoms at 55. AV symptoms the most bothersome as overnight I shrunk up, dried up, itched, burned and tore. Intercourse was out of the question. Dr. gave me a sample of Estrace Vaginal cream. I admit I was afraid to use it and had little faith that it would help so I used only a pearl size amount on clean dry skin every night for 2 weeks. That ammt. Is sufficient to cover all the external parts and more, it emulsifies. I am COMPLETELY healed as far as pain with intercourse and also pain upon urination. It was a MIRACLE for me. Side note: If you stop using it (3X a week after the initial 2wk nightly use) you'll be back at square 1. I give Estrace a 10+ rating C: A tube lasted 6 months”

10 / 10
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Blondie · Taken for 1 to 2 years June 2, 2019

Vagifem (estradiol) for Atrophic Vaginitis: “Got prescribed Vagifem about 18 months ago and original hair loss was minimal. Had used this on and off in that time. More hair loss. Ouch. Used or started again a month ago. Experienced major hair loss and now have half as much as I used to. Scalp is visible in lots of areas. Will never use again and can only hope that hair will return.”

5 / 10
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CeeGal · Taken for 1 to 6 months December 16, 2016

Estrace Vaginal Cream (estradiol) for Atrophic Vaginitis: “I've been married for 35 years. After menopause, intercourse became impossible due to dryness and pain. I do not go to the doctor as often as I should, so I suffered for years, and tried to find "natural remedies" on my own to no avail. I finally gave in and went to a gynecologist. I was embarrassed to even tell him, but I knew I had to do something. He was familiar with the problem and put me on Estrace cream. Within days, I was a NEW person. Saved my life and my marriage. Excellent results and fast!”

10 / 10
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denah November 18, 2013

Estrace Vaginal Cream (estradiol) for Atrophic Vaginitis: “I am 50 yrs old and post menopausal - basically in full menopause.. I was prescribed this cream for thinning of the vaginal wall. I had increased urinary tract infections. I believe it helps with my libido which had dropped to zero! I hope this review helps. I didn't have dryness or pain with intercourse. My urologist prescribed it for me. It is really great to have doctors who "KNOW" what we are going through as females.”

10 / 10
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Gal · Taken for 1 to 2 years August 18, 2020

Vagifem (estradiol) for Atrophic Vaginitis: “I am in my late 60's and for the past few years have suffered at least 6-7 urinary tract infections a year. The urologist suggested using Vagifem as directed and apart from headaches and nausea for the first few days have not had any problems and my urinary tract infections have dropped significantly to 1-2 a year. I now only use it once a week and find this sufficient for keeping everything comfortable. I live in the UK so my prescriptions are free. I will continue using it for as long as my general practitioner is happy to prescribe it.”

10 / 10
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Leyaleo · Taken for 1 to 6 months September 3, 2014

Estrace Vaginal Cream (estradiol) for Atrophic Vaginitis: “Just posting an update from my last post a few months ago. The hypoallergenic estradiol (basically, a compounded version of Estrace from a compounding pharmacy) continues to be very effective for me - relieving vaginal burning/pain and urinary urgency/frequency. For women out there suffering those issues in perimenopause (when it hit me), know that it was suggested that I had interstitial cystitis and that I was off-base when I told doctors I was reacting badly to propylene glycol and glycerin, ingredients in many vaginal products. The compounded version of Estrace has been SO helpful for me and after many painful, difficult months, I feel myself again. ”

9 / 10
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Anon · Taken for 2 to 5 years June 19, 2018

Estrace Vaginal Cream (estradiol) for Atrophic Vaginitis: “For those who commented about burning from using Estrace...I also had burning from it. My research led me to believe that the propylene glycol and/or glycerin in the product were the culprits. I switched to a hypoallergenic form of estradiol from a good compounding pharmacy and that solved the problem. No burning and the estradiol was so helpful.”

9 / 10
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Kimmiepoo11 September 16, 2020

Imvexxy (estradiol) for Atrophic Vaginitis: “After dealing with atrophy following a total hysterectomy, my Doc suggested Imvexxy. Let's start with the positives: It DID what it was supposed to do, painful sex vanished after using it only a week and 1/2 and I felt better in the nether regions. Now for the "not so" positives: I noticed my hair thinning, and had a slight headache. In the 2nd week I noticed a rash on my arms(elbow down) and legs. My Family Doc treated me with steroids, but it started right back following treatment, I decided to stop Imvexxy on a hunch, and after nearly two weeks the rash began to fade. When I mentioned this to my Gyn, she said you must be allergic to coconut oil.... I use coconut oil every day with no issues. The ONLY thing different before all this mess was starting Imvexxy. Bottom line if anyone did have a rash after this medication and was told "That's not the cause." by their Doc. you are not alone. I am trying another (non-hormonal) product as it had some good reviews...just to see.”

4 / 10
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This information is NOT intended to endorse any particular medication. While these reviews might be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare practitioners.