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User Reviews for Estradiol topical to treat Atrophic Vaginitis

Also known as: Vagifem, Estrace Vaginal Cream, Yuvafem, Estring, Imvexxy

Estradiol topical has an average rating of 4.9 out of 10 from a total of 322 ratings for the treatment of Atrophic Vaginitis. 37% of reviewers reported a positive effect, while 48% reported a negative effect.

Estradiol topical Rating Summary

4.9/10 average rating

322 ratings from 358 user reviews.

Compare all 42 medications used in the treatment of Atrophic Vaginitis.

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Reviews for Estradiol topical

Ellie · Taken for 2 to 5 years September 21, 2020

Estrace Vaginal Cream (estradiol): “Horrible itching, burning, swelling from any topical estrogen I tried - estrace, vagifem, premarin. After 3 years of suffering, all with normal cultures (no infection), I insisted on biopsy of vulva - showed probable hypersensitivity reaction from allergy!!! Stopped all estrogens, but atrophic vaginitis returned with different burning and dryness, and painful sex. Then researched and found out that topical estrogens can cause all my symptoms from allergic reaction to the preservatives and other ingredients! My gyn had no clue. I researched this, and told doctor to order Estriol cream in VERSABASE cream base - versabase is hypoallergenic. I AM CURED - the compounded estriol in versabase has fixed my atrophic vaginitis without allergic reaction. I have my vagina back! Find a compounding pharmacy - I use estriol 1 mg/gram compounded - daily x 2 weeks then twice a week. Call around as the different compounding pharmacies have huge price differences for the same compound. Good luck!!!!”

1 / 10
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Jlady May 28, 2013

Estrace Vaginal Cream (estradiol): “I'm 71 years old. The tearing and associated pain started a few months ago. Just hoped it would go away but it did not. I would not let my husband touch me. Spoke with 2 doctors I know and they said its normal but Estrace would help. It did. My prescription is dated 3/7/2013. Within 10 days the tearing stopped and all was healed. Use 1 gram 3 X a week. Nothing bad has happened. My libido near immediately was through the roof. I am amazed and nobody needs to try and take this medicine away from me! I'm loving it and my husband is happy too. Yes, my age up there is right.”

10 / 10
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Gal · Taken for 1 to 2 years September 17, 2020

Vagifem (estradiol): “I left a comment in August regarding Vagifem and gave it 10/10 for curing my symptoms of repeated urinary tract infections but over the last few weeks since starting a new box of Vagifem I have noticed that for the first 2 days after using it I too am getting a stinging feeling in the vagina which also makes me feel like I have a urinary tract infection and tingling in the breasts which I have not experienced before. Reluctantly I have stopped the medication as these new symptoms are too uncomfortable and I am wondering if the manufacturer has changed the formula. Not happy.”

7 / 10
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twistedK · Taken for less than 1 month January 23, 2016

Estrace Vaginal Cream (estradiol): “So - I was prescribed this and was shocked when I went to the pharmacy and she said $135. Dr. never mentioned this. I said "doesn't my insurance pay anything on this?" She checked and said "It's normally $350.00" or something. I was really angry. Angry, embarassed and this whole experience is humiliating to women. Why do I think a prescription of Viagra has a co-pay of like $10?? IT'S TIME TO STOP DISCRIMINATING AGAINST WOMEN. Especially us older women!!! That is ridiculous!!! I did not buy it, I was so angry. I may.... but I doubt it. I was prescribed this with an oral progesterone -- any one have experience with these two items combined? Thanks for letting me air that - take heed, Big Pharma.”

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Pookie · Taken for 10 years or more March 10, 2020

Vagifem (estradiol): “Does anyone know if any of the ingredients have changed recently? I have been using vagifem for almost 15 years once a week and never experienced any burning but recently out of the blue I have burning and cannot understand why as I am using the brand and not the generic as that caused horrible problems. It works great but not happy with the irritation. Thank you.”

8 / 10
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Wonder woman · Taken for less than 1 month March 18, 2021

Vagifem (estradiol): “I was prescribed Vagifem finally after a year of burning, painful sex and constant urine infections. Literally after 3 days the burning was 70% better and I actually enjoyed sex for the first time in ages ! Totally recommend Vagifem and I've had zero side affects . Still got every other peri menopause symptom but one less to deal with is a huge relief! Good luck ladies !”

9 / 10
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whims · Taken for 2 to 5 years January 6, 2021

Imvexxy (estradiol): “I'm 65 years old I started Imvexxy when I turned 62 and it worked for me I thought life was great again then I turned 65 and Medicare/Blue Cross entered my life the price is over 200 dollars a month for me and of coarse my insurances will not cover that at all so it is out of my pocket ! I had to turn to a different brand this brand does not work for me sad to say . Why would Imvexxy get you hooked and then once you really need at our age and you cant afford it !!!!!”

8 / 10
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M · Taken for less than 1 month April 12, 2021

Vagifem (estradiol): “Worst 'medication' I've ever had. Horrific headache, couldn't even get up out of bed safely the day after one and only application, extreme nausea and dizziness, next few days spotting, vaginal pain, burning for the next two weeks until I took some acid regulators. Subsequently have been sleepless, extremely low on energy, cystitis, cold sore - basically everything saying the body's taken a beating. One pessary. Still battling it four weeks later. Never again.”

1 / 10
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letmepost654 · Taken for 5 to 10 years July 16, 2013

Estrace Vaginal Cream (estradiol): “I'm 65 and had ovaries removed 11 years ago, along with uterus and cervix. Since that, I have almost no sex drive and intercourse was super painful. Estrace vaginal cream really helps, and I only have to use a pea sized dab every other day. Just using a finger to apply at bedtime works great. It seems to me that the dire warnings about using estrogens is misleading since no studies have been done on just vaginal estradiol rather than on oral estrogen, and much higher doses are still prescribed than are needed for maintenance. Without Estrace vaginal cream, intercourse would be impossible and husband would be very unhappy. ”

10 / 10
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Sara55 · Taken for less than 1 month December 30, 2019

Estrace Vaginal Cream (estradiol): “I was using Estrace and was doing very well. Then they approved the generic Estradiol. I can already tell the difference. I’m itching and sex is painful again. Estrace is too expensive now that the generic has been released. Also Allergen offered free applicators but Mylan won’t even answer an e- mail regarding this. I think it VERY unsanitary to expect one to reuse the tubes. Allergen won’t even respond when I asked if I could buy the applicators for the generic- I did find them on Amazon for $33 a bag. Thinking about paying full price for the Estrace to get the free applicator program again. I’m going to try this generic a few more times. If I don’t see improvement and still have issues, I’m stopping it and reporting it to the FDA. Does anyone else have problems with generic but was doing great on Estrace brand??”

8 / 10
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Lola F · Taken for 1 to 6 months May 9, 2021

Vagifem (estradiol): “I've been using vagifem for a few months now & definitely took several weeks for my symptoms to calm down. Before using this my entire vaginal area had become dry, hyper sensitive & sore & sex was so painful, vagifem has restored lubrication & feel like me again, so happy with results. Also have had no hot flashes since I started taking it & these were happening multiple times a night also not had a UTI since & have been having them every couple of months most of my adult life.”

10 / 10
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Gram · Taken for 1 to 6 months June 6, 2019

Estrace Vaginal Cream (estradiol): “I am 71 years old and my doctor prescribed estradiol for vaginal atrophy. I was reluctant to try it but my symptoms worsened so I started the estradiol 3 times a week. After a few weeks I was symptom-free and feeling great. However after 3 months my symptoms gradually returned and now I have burning all day and the urination urgency off and on during the day. My symptoms abate at night. My doctor doesn’t have any answers as to why the medication stopped working. Does anyone else have this problem and what was your solution.?”

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Dc March 22, 2021

Estrace Vaginal Cream (estradiol): “I felt like I had a UTI for several months and was losing sleep due to the sensation of needing to urinate constantly. There were also lots of BV and yeast infections so it was frustrating. I found an official OBGYN who was a God send. I’m replying early on with this medicine because after a few days all of the old symptoms were gone. Into it a bit over a week and feel normal again. When I started it I think I was so dried out that my skin could not even absorb this internally as I’d see it the next morning (I assume it was the cream), but even with that - it has helped and I hope they don’t stop prescribing. Quality of life and comfort is important for mood stabilization etc. No point in living to be 100 if it’s painful everyday. Love this cream.”

10 / 10
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sammie · Taken for less than 1 month April 3, 2020

Vagifem (estradiol): “I tried Vagifem for two weeks and while I think it probably helped with soreness inside and plumped things up, it also caused irritation of the uretha whereby I had a constant pressure, feeling like a need to wee all the time, burning and stinging inside. I couldn't live with it and it kept on waking me up at night. These symptoms started when I used vagifem and stopped when I stopped it. I really hope there is an alternative as I think for many vagifem is a miracle.”

5 / 10
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Chads · Taken for 5 to 10 years May 7, 2021

Vagifem (estradiol): “I have been using Vagifem for many years now and although it's helped my symptoms a great deal, I find the recommended dosage of 1 pessary twice a week is not enough to keep me comfortable, however my dr refuses to prescribe me any extra. Imagine my surprise on visiting the Menopause Matters site to find many women on there are prescribed it 5x a week as twice a week doesn't relieve their symptoms. Apparently each Vagifem pessary used to be 25mcg (=50mcg a week) but for some unknown reason they reduced it to 10mcg per pessary (=20mcg a week)”

7 / 10
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Lea · Taken for 6 months to 1 year November 13, 2020

Imvexxy (estradiol): “I have been taking Imvexxy 10mg twice a week for about 10 months now. I had dryness on the outside of my personal area, more so then the inside dryness. I'm 64 with a healthy sex life. My husband thought it made me too lubricated and he didn't care for it. After two months I noticed night sweats, and some hair loss along with slight headaches. Mostly the night sweats was my big problem. I adjusted to 1 time a week of the 10mcg for a month, but still had night sweats. Now, I have been totally off Imvexxy for two weeks and noticed the night sweats have lightened up a bit. I am going to continue to stay off for 6 weeks to see if there is a big difference with the night sweats, hoping they disappear completely. I did not have this problem before I was on Imvexxy. The reason I was checking out these reviews was to see if anyone else had these same side effects, please let me know if you do.”

8 / 10
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Anon · Taken for 2 to 5 years June 19, 2018

Estrace Vaginal Cream (estradiol): “For those who commented about burning from using Estrace...I also had burning from it. My research led me to believe that the propylene glycol and/or glycerin in the product were the culprits. I switched to a hypoallergenic form of estradiol from a good compounding pharmacy and that solved the problem. No burning and the estradiol was so helpful.”

9 / 10
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Sexpert March 30, 2016

Estrace Vaginal Cream (estradiol): “Very sexually active until severe abrupt menopausal symptoms at 55. AV symptoms the most bothersome as overnight I shrunk up, dried up, itched, burned and tore. Intercourse was out of the question. Dr. gave me a sample of Estrace Vaginal cream. I admit I was afraid to use it and had little faith that it would help so I used only a pearl size amount on clean dry skin every night for 2 weeks. That ammt. Is sufficient to cover all the external parts and more, it emulsifies. I am COMPLETELY healed as far as pain with intercourse and also pain upon urination. It was a MIRACLE for me. Side note: If you stop using it (3X a week after the initial 2wk nightly use) you'll be back at square 1. I give Estrace a 10+ rating C: A tube lasted 6 months”

10 / 10
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CeeGal · Taken for 1 to 6 months December 16, 2016

Estrace Vaginal Cream (estradiol): “I've been married for 35 years. After menopause, intercourse became impossible due to dryness and pain. I do not go to the doctor as often as I should, so I suffered for years, and tried to find "natural remedies" on my own to no avail. I finally gave in and went to a gynecologist. I was embarrassed to even tell him, but I knew I had to do something. He was familiar with the problem and put me on Estrace cream. Within days, I was a NEW person. Saved my life and my marriage. Excellent results and fast!”

10 / 10
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Leyaleo · Taken for 1 to 6 months September 3, 2014

Estrace Vaginal Cream (estradiol): “Just posting an update from my last post a few months ago. The hypoallergenic estradiol (basically, a compounded version of Estrace from a compounding pharmacy) continues to be very effective for me - relieving vaginal burning/pain and urinary urgency/frequency. For women out there suffering those issues in perimenopause (when it hit me), know that it was suggested that I had interstitial cystitis and that I was off-base when I told doctors I was reacting badly to propylene glycol and glycerin, ingredients in many vaginal products. The compounded version of Estrace has been SO helpful for me and after many painful, difficult months, I feel myself again. ”

9 / 10
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denah November 18, 2013

Estrace Vaginal Cream (estradiol): “I am 50 yrs old and post menopausal - basically in full menopause.. I was prescribed this cream for thinning of the vaginal wall. I had increased urinary tract infections. I believe it helps with my libido which had dropped to zero! I hope this review helps. I didn't have dryness or pain with intercourse. My urologist prescribed it for me. It is really great to have doctors who "KNOW" what we are going through as females.”

10 / 10
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AE October 23, 2019

Yuvafem (estradiol): “Amneal had two companies producing their Yuvafem product. One company located in the USA (pink packaging) and the other in Denmark (blue packaging). I did not experience issues with the product manufactured in Denmark although the packaging was inferior to Vagifem. Amneal no longer uses the company in Denmark. The product in the pink packaging manufactured in the USA is as awful as the many negative reviews reflect. Burning and itching was the worse negative symptoms for me. Why is the FDA not aggressively addressing this. I have been battling with Amneal and it isn't a pleasant experience. I plan to escalate to the Attorney General of my state. Unfortunately too many politicians take money from the pharmaceutical companies so they do nothing to help stop the this abuse. I also take issue with the majority of insurance companies refusing to cover Vagifem or charge exhorbitant copays for a medication women need to maintain good health yet many have no problem with covering Viagra.”

1 / 10
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Zero waster · Taken for less than 1 month October 3, 2021

Vagifem (estradiol): “The pessaries might be fine but the packaging is insane. Each pessary has its own plastic applicator. And is individually wrapped in foil and plastic. It's an absolute disgrace. Pessaries and one reusable applicator please. Stop wrecking the planet with this sort of ridiculous over packaging”

1 / 10
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Pob · Taken for 5 to 10 years October 16, 2020

Vagifem (estradiol): “I have been on low dose (10mg) Vagifem for the past 9 years at least, I have always tolerated it well, but recently have experienced feelings of discomfort and I wonder if the manufacturing process of the pessary has changed?.”

10 / 10
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InPain · Taken for less than 1 month September 28, 2019

Estrace Vaginal Cream (estradiol): “I am 53 and had a complete hysterectomy 27 years ago and have been taking oral Premarin. Dr. Put me on the Estradiol patch which gave me headaches so we just stopped all HRT. Few weeks later I developed a UTI and had extreme vaginal and urethra pain. Was put on Estradiol Cream which irritated all of my skin, so they switched me to Estradiol vaginal tablets. I have been using it for 10 days and I am burning, aching and it feels like something is stuck in me. I do not like this cream and am wondering if the Premarin cream would work better. I keep wondering if this pain will ever go way. Has anyone had symptoms for over 10 days while using the cream?”

1 / 10
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This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare professionals.

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