Skip to Content
Print Share

Comparing Diclofenac vs Tylenol

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Diclofenac Remove Diclofenac from your drug comparison Tylenol Remove Tylenol from your drug comparison
View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Diclofenac Remove Diclofenac from your drug comparison Tylenol acetaminophen Remove Tylenol from your drug comparison

Diclofenac is an effective medicine for relieving pain but may be associated with an increased risk of cardiovascular and gastrointestinal side effects. Prescribed for Back Pain, Frozen Shoulder,... View more

Tylenol is an effective mild pain reliever with a low risk of side effects. Prescribed for Sciatica, Muscle Pain, Pain, Fever. Tylenol may also be used for purposes not listed in this medication... View more

Prescription only

Prescription and OTC

Ratings & Reviews

Recent helpful reviews
7.6
585 Reviews

For Pain: Diclofenac takes the edge of my hip pain.

7 / 10

For Pain: Gained a greater range of motion after rotator cuff surgery.

7 / 10
6.7
21 Reviews

For Pain: I would take two 500mg pills once a day. I used it for occasional tooth aches because of my braces. It helped alot. Alot better than ibuprofen or naproxen actually.

8 / 10

For Pain: Only over the counter pain med I can take with Crohn's disease. All other pain killers have some degree of aspirin in them. For those with stomach diseases acetaminophen (Tylenol) is the only thing we can take.

9 / 10

View all 585 reviews

View all 21 reviews

Drug Class

Side Effects

See the full diclofenac side effects document.

See the full Tylenol side effects document.

Pricing and Coupons

* Prices are without insurance
Quantity 10 delayed release tablet
Dosage sodium 75 mg
Per Unit* $1.37 - $1.43
Cost* $13.71 - $14.27

View all diclofenac prices

Quantity 1000 each
Dosage 325 mg
Per Unit* $0.06
Cost* $57.18

View all Tylenol prices and generic prices

Get free Discount Card

Get free Discount Card

Generic Availability

Yes (this medicine)

Yes

Dosage Form(s) Available
  • Oral capsule
  • Oral delayed release tablet
  • Oral tablet
  • Oral tablet, extended release
  • Oral tablet

Brand Names
Cambia, Cataflam, Voltaren, Zipsor, Zorvolex Other acetaminophen brands include: 7T Gummy ES Chewable Tablets, Abenol, Acephen, Actamin, Actimol Children's, Actimol Infant, Adprin B, Aldi Hedanol Paracetamol, Alpha First Aid Supplies Paracetamol, Alphapharm Paracetamol, Altenol, Alvedon, Amadol Paracetamol, Amcal Childrens Paracetamol 1-5 Years, Amcal Childrens Paracetamol 5-12 Years, Amcal Paracetamol Infant Drops 1 Month to 2 Years, Amcal Paracetamol Pain Relief, Amcal Paracetamol Tabsules, Aminofen, Anacin Aspirin Free, Anadin Paracetamol, API Healthcare Coloufree Childrens Paracetamol, API Healthcare Colourfree Childrens Paracetamol Double Strength, API Healthcare Paracetamol, Apra, Arthritis Pain Relief, Atasol, Atasol Forte, Aurophen, BF-Paradac, Bi-Lo Paracetamol, Biochemie Paracetamol, Blooms the Chemist Paracetamol, Bristol Pharma Paracetamol, Buckley's Complete, Bydol, Calpol Fastmelts, Calpol Infant, Calpol Paediatric, Calpol Six Plus, Capital Chemist Paracetamol, Cetafen, Cetafen Extra, Chem Mart Chemadol, Chem Mart Chemadol Children 1 to 5 Years, Chem Mart Chemadol Colourfree, Chem Mart Chemadol Colourfree Children 5-12 Years, Chem Mart Chemadol Colourfree Childrens 1-5 Years, Chemists Own Chiildrens Paracetamol 5-12 Years, Chemists Own Childrens Paracetamol 1-5 Years, Chemists Own Paracetamol, Chemists Own Paracetamol Capseals, Chemists Own Paracetamol Pain & Fever 1 Month to 2 Years, Chemists Own Paracetamol Pain & Fever 1 to 5 Years, Chemists Own Paracetamol Pain and Fever 5 to 12 Years, Chemplus Paracetamol, Chemworld Colourfree Childrens Paracetamol Double Strength 5-12 Years, Chemworld Colourfree Childrens Paracetamol Junior 1-5 Years, Chemworld Paracetamol, Chemworld Paracetamol Infant Colour Free, Children's ElixSure, Children's Silapap, Children's Tylenol, Childrens Panadol 1 - 5 Years, Childrens Panadol 1 - 5 Years Colourfree, Childrens Panadol 5 - 12 Years, Childrens Panadol 5 - 12 Years Colourfree, Cipla Genpharm Paracetamol, Claradol, Coles Paracetamol, Conacetol, Conney Aspirin-Free, ConRx Extra Strength, Country Chemists Paracetamol, Cuprofen for Children, Dafalgan, Dakota Paracetamol, DG Health Pain Reliever, Disprol Paracetamol, Disprol Soluble Paracetamol, Doliprane, Doliprane Adultes, Doliprane Sans Sucre, Dolitabs, Dolko, Dolko Enfants, Dolono, Dolono Infant, Dolotec, Duatrol SR, Dymadon, Ed-APAP, Efferalgan, Efferalgan Pediatrique, Efferalganodis, Elixsure Fever/Pain, Equaline Pain Relief, Expandox, Fawns & McAllan Paracetamol, Febridol, Febridol Clear Effervescent, Febridol Infant Drops, Febridol Syrup for Children, Febrol Solution, Fennings Childrens Cooling, Feverall, Flu Strength Hot Lemon Powders, Galpamol, Geluprane, Genapap, Genapap Extra Strength, Genebs, Gold Cross Paracetamol, Guardian Childrens Paracetamol, Guardian Childrens Paracetamol 5-12 Years, Guardian Paracetamol, Guardian Paracetamol Tabsules, Help I Have A Headache, Home Brand Paracetamol, HyVee Health 8 Hour Pain Relief, Infant's Tylenol, Infantaire Drops, Jr. Tylenol, Leader 8 Hour Pain Reliever, Lemsip Childrens Cold & Flu, Lemsip Cold and Flu Liquid Capsule, Lemsip Headcold, Lemsip Max, Lemsip Original, Lemsip Pharmacy Non-Decongestant Formula, M-Pap, Mapap, Mapap Arthritis Pain, Mapap Extra Strength Rapid Burst, Mapap Rapid Release Gelcaps, Mapap Rapid Tabs, Masophen, Midol Long Lasting Relief, Nortemp Children's, Ofirmev, Orajel Maximum Strength Toothache, Panadol, Panadol ActiFast, Panadol Childrens, Panadol Colourfree Drops, Panadol Extend, Panadol Gel Caps, Panadol Gel Tabs, Panadol Jr, Panadol Mini Caps, Panadol Osteo, Panadol Rapid Handipak, Panadol Soluble, Panamax, Panamax 240, Panamol, Paracetamol, PediaCare Children's Acetaminophen Fever Reducer/Pain Reliever, PediaCare Infants' Acetaminophen Fever Reducer/Pain Reliever, PediaCare Smooth Melts Acetaminophen Fever Reducer/Pain Reliever, Pharbetol, Silapap Childrens, Tactinal, Tempra Quicklets, Topcare 8 Hour Pain Relief, Topcare Arthritis Pain Relief, Triaminic Fever Reducer Pain Reliever, Triaminic Infant Drops, Tycolene, Tylenol 8 Hour, Tylenol Arthritis Pain, Tylenol Childrens Paracetamol, Tylenol Cold Sore Throat, Tylenol Cool Caplet Extra Strength, Tylenol Extra Strength, Tylenol Regular Strength, Tylenol Sore Throat Daytime, Tylophen, UN-Aspirin Extra Strength, Valorin, Vicks Formula 44 Custom Care Body Aches, Vitapap, Zee Unaspirin ES View more

Half Life

The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

1.8 hours

2.5 hours

CSA Schedule**

View glossary of terms.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category
D
Category D Positive evidence of risk

See the full Pregnancy Warnings document.
C
Category C Risk cannot be ruled out

See the full Pregnancy Warnings document.

FDA Alerts

FDA Alerts (10)

FDA Alerts (14)

Drug Interactions

A total of 383 drugs are known to interact with diclofenac:

  • 69 major drug interactions (265 brand and generic names)
  • 296 moderate drug interactions (1222 brand and generic names)
  • 18 minor drug interactions (93 brand and generic names)

A total of 116 drugs are known to interact with Tylenol:

  • 8 major drug interactions (21 brand and generic names)
  • 73 moderate drug interactions (363 brand and generic names)
  • 35 minor drug interactions (168 brand and generic names)

Alcohol/Food/Lifestyle Interactions
  • Ask your doctor before using diclofenac together with alcohol. Do not drink alcohol while taking... View more
  • Ask your doctor before using acetaminophen together with alcohol. This can cause serious side... View more

Disease Interactions

First Approval Date

July 28, 1988

June 08, 1994

WADA Class

View World Anti-Doping Agency classifications.

N/A

N/A

More Information

Consumer Resources

Professional Resources

N/A

Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Drugs.com Mobile Apps

The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Available for Android and iOS devices.

Explore Apps