Comparing Azathioprine vs Rituximab

For Ulcerative Colitis: Have had UC since 1991 and been on Prednisolone and Asacol which became ineffective. Severe attack October 2016 - spent 10 days in hospital. IV steroids and then sent home on reducing steroids - symptoms began to return. Azathioprine prescribed. Certainly helped reduce and eventually stop UC bleeding. Trips to the toilet reduced to around 3 or 4 occasions . Initially caused liver function problems which improved. However the drug has shattered my immune system - have taken any cold, cough or flu that crops up. Makes me fatigued after around 40 minutes exertion. Cannot now play golf, take hill walks or do heavy garden work etc. I guess it is good for some patients and not so good for others. Seeing consultant soon and will discuss options.

For Ulcerative Colitis: This medicine seemed to work at first, the negatives ultimately were worse than the positives. It did put me down to about 4 bowel motions a day but it was at the cost of horrendous acne, terrible headaches, joint pain and fatigue. Doctor still has me on it for another autoimmune disease but keeps me at a minimum.

For Rheumatoid Arthritis: Rituxan was prescribed for my RA about 8-10 years ago and allowed me to continue working full time putting the max away for retirement. Some fatigue occasionally but no joint pain. After retirement, the combination of allergy to a new huge Maine Coon cat causing chronic congestion AND the suppression of my autoimmune system by years of Rituxan - led to repeated chest, ear and sinus infections. After many tests, allergy shots and several consultations with specialists, the Rituxan was discontinued. Now (2 years later) no more infections but the RA is up and raging again. New hand and finger damage as well as bunions and flares on toes that had never occurred before. My doctor is waiting for a fifth Simponi infusion in 2-3 weeks before moving on to another drug. Simponi has done nothing. What is there for me to take at this point?

For Rheumatoid Arthritis: I am sat having my 10th cycle, 1st infusion of rituximab. Sleepy while having infusions otherwise no side effects. Previously I could not walk or look after myself. I had no quality of life. Now enjoying life with a little help. My rheumatoid hasn't gone completely but is more manageable to deal with. Not pain, or inflammation free but much better than I was. I know the side effects can sound very scary but discuss this with your consultant or specialist nurse. They are very helpful, very informative and understanding. They do not know the long term side effects of this drug but more importantly I can now live a life as before I was just existing. Try not to be daunted, ask, ask, ask and don't be afraid to try new drugs they might help