Semaglutide and Upset Stomach: What Users Say (Page 5)

• Pum...
• Taken for less than 1 month
• August 21, 2019

Semaglutide for Type 2 Diabetes "Endo gave me a 1-month sample for type II. Just into my second week at 0.25. Initially, upset stomach and diarrhea. Wouldn't say nausea per se, more like a stomach ache. Diarrhea wasn't crampy and prolonged like metformin. Appetite really decreased. Sugars started going down about 3-4 days in, and symptoms lessened by day 6. But.... weight gain of 3 lbs! What the...? Just on day 2 of the 2nd week, no nausea, but still eating less. Not peeing as much and waking up earlier and easier, and morning sugars down from 11-12ish to 8-9ish. I will be disappointed if I am the rare one that gains weight though."

• Pum...
• Taken for less than 1 month
• August 21, 2019

Semaglutide for Type 2 Diabetes "Endo gave me a 1-month sample for type II. Just into my second week at 0.25. Initially, upset stomach and diarrhea. Wouldn't say nausea per se, more like a stomach ache. Diarrhea wasn't crampy and prolonged like metformin. Appetite really decreased. Sugars started going down about 3-4 days in, and symptoms lessened by day 6. But.... weight gain of 3 lbs! What the...? Just on day 2 of the 2nd week, no nausea, but still eating less. Not peeing as much and waking up earlier and easier, and morning sugars down from 11-12ish to 8-9ish. I will be disappointed if I am the rare one that gains weight though."

• Cpa...
• July 1, 2019

Semaglutide for Type 2 Diabetes "I've been taking Ozempic for six weeks. I'm experiencing a lot of the same side effects as everyone else. No nausea, but definitely the cramping, bloating, sore stomach, and constipation. Had to do two fleet routines already. Weight loss has been fantastic, but I'm beginning to worry now. Twenty pounds so far and still dropping. .25 mg dose. Sugar numbers have been great. Don't think it's worth all the side effects. Going back to Farxiga. Much more predictable."

• Jen...
• Taken for less than 1 month
• June 29, 2025

For Weight Loss (Obesity/Overweight) "I’m a 47-year-old female who gained 30 pounds over the last 2 years after I quit smoking and drinking. I’m at my highest weight of my life. I’m 5’6” and currently 215 lbs. I’m starting semaglutide next week, but I’m extremely scared of the side effects. I have stomach issues and acid reflux as it is, and these reviews have me terrified. I’m going to give it a shot (see what I did there) and see what happens. I’ll update here weekly with what’s happening. Wish me luck!"

• Ano...
• Taken for less than 1 month
• June 26, 2025

Semaglutide for Type 2 Diabetes "Week 4 and having some stomach issues, bloating, gas."

• Ano...
• Taken for less than 1 month
• June 19, 2025

Semaglutide "Diarrhea, stomach cramps, bad breath. Felt I could not eat anything."

• edw...
• Taken for 1 to 6 months
• January 28, 2025

Semaglutide for Type 2 Diabetes "Insurance is Medicare Advantage AARP United Health. The 1st 3-month supply was $130. The 2nd 3-month supply was $450. I expect the medication will not be affordable for the future. There was no advantage in the first 3 months taking the 3 mg dosage. A1C is 7.4% from 7.6%. Now taking the 7 mg dosage; waiting for my next doctor evaluation on Feb. 26, 2025. I get frequent headaches, dizziness, upset stomach, bloated feeling, and sleepy/low energy levels. No weight loss."

• Sta...
• Taken for less than 1 month
• September 16, 2024

Semaglutide for Type 2 Diabetes "In the first 30 days now. No changes yet, but stomach cramps aren’t nice."

• coo...
• Taken for 1 to 6 months
• March 6, 2023

Semaglutide for Type 2 Diabetes "I just started taking the 0.5 after taking the 0.25 for 4 weeks. I'm experiencing nausea, some vomiting, and bad stomach cramps, so I really don't know if I'm going to be able to keep taking it. It has curved my appetite some."

• Jan...
• Taken for 1 to 6 months
• March 15, 2021

Semaglutide for Type 2 Diabetes "My doctor gave me Ozempic 0.5 to start with. I always had upset stomach, diarrhea with most foods, and an overall sick feeling all the time. I was able to 'live' with it until now. She decided to up my dose to the 1.0 and my body went into total chaos. I am always nauseous, constipated, got reflux, feels like my food is stuck in my stomach and doesn't go anywhere. I'm constantly burping and feeling bloated. The sick feeling feels intensified and I cannot function at work. I took my last one this past Friday night and was miserable all weekend long. Today I am at work unable to function at my best because the nausea is bad. I would say it is effective in lowering your blood sugar numbers and helping you lose weight but not worth feeling horribly sick over. I will not be using this medication any longer."

• Ang...
• December 11, 2019

Semaglutide for Type 2 Diabetes "It was good on low dosage 0.25, but after 2 months, it loses effect, and you need to increase the dose. Still fine, I lost 30 pounds, but then you have to increase the dosage, and that's when I got stomach aches and diarrhea, and I had to stop it."

• Ice...
• Taken for less than 1 month
• November 4, 2019

Semaglutide for Type 2 Diabetes "OMG ... it’s not me. Dr. started me at .5 of Ozempic, first day after injection pretty much okay, then came nausea, stomach ache, headaches, then just dulled, gassy (didn’t know the burps were part of it but that increased), diarrhea, feeling beyond blah. I went to work and struggled through the day for 4 days like this. The first week wasn’t sure if it was the shot or some food, so I tried the Ozempic again. The second week was a little better, so I decided I’ll try the smaller dose. Today is day 2, but this morn, there’s the nausea, stomach ache, a little bit of headache, but lesser amounts. Despite the thought of weight loss, might be heading back to Januvia (Farxiga got the yeast infection, but it was cheap, $15 for 90 with insurance)."

• SAL...
• Taken for 1 to 6 months
• June 26, 2019

Semaglutide for Type 2 Diabetes "Been on Ozempic since March 2019, started off with 0.25, then 0.50, then to 1 mg. Side effects: nauseous, constipated, with fever. One month into taking Ozempic, started to have blood in my urine, no infection, CT, blood clots, bladder scope, bladder okay. CT with contrast upcoming to check kidneys, and my urine tests are concerning the PA. When giving the shot, medicine would make a bubble under the skin, then welt up 1 inch wide, 3 inches in length, and at least a .5 inch depth, 36 hours later with high fever, diarrhea, stomach cramps, large amounts of blood clots in urine, 3 times. Called Ozempic, which requested the medication back and sent a voucher for a new script. I have been taking this for 4 months, note I am not a doctor, just concerned, so I believe this could be a drug that has not been fully evaluated and may not have full understanding, or it's an odd situation for myself. However, these symptoms did not show up until on Ozempic. So for my own health, I have opted not to continue this drug."

• PDH...
• Taken for 1 to 6 months
• June 21, 2019

Semaglutide for Type 2 Diabetes "I started Ozempic about 3 months ago at .25 mg. My doctor made me start my 1st dose on a Monday in her office because I would tell her I would try and then never do it. Tuesday morning I was good, then by Tuesday night, stomach cramps, nausea, vomiting, and diarrhea, till the wee hours of the morning. The symptoms slowed down throughout the week. Even though I was losing at least 3-4 pounds a week, a total of 35 pounds within a 2 1/2 month period. My A1C did go down, the side effects are deadly. I like the fact that I am losing weight, but I hope I don't have permanent damage from this medication."

• Swi...
• Taken for 1 to 6 months
• May 13, 2019

Semaglutide for Type 2 Diabetes "Started on Ozempic 5 months ago for diabetes 2. Started at 0.25, then 0.50, now at 1.00, and so far I lost weight - 35 lbs. But I’m feeling really fatigued, dizzy, and occasional stomach ache, diarrhea, and my eyesight has changed. Great drug for lowering A1C and losing weight, but the side effects are horrible. I think I’m done taking this drug. Side effects are getting worse."

• JLa...
• Taken for 1 to 6 months
• May 3, 2019

Semaglutide for Type 2 Diabetes "I've been on Ozempic 0.25 for five weeks, it's great for losing weight, but the side effects are not worth it. Let me review what Ozempic has been like. The first three weeks were okay, and then I started noticing nausea, stomach burning, headache, dizziness, upper back pain, severe constipation, and feeling very tired and depressed. I ended up in the ER with a mild pancreatic attack and high lipase levels. I've had no desire to eat or even drink water. It makes me gag, and I used to drink a lot of water. I'm done with these injections. I will stay on my metformin, but I can do better on a healthy eating lifestyle than on Ozempic and all the negative side effects. Quality of life has gone from a 10 to a 1, and that is not me. I'm taking my life back. It's really just healthy eating, and we can all do that with willpower. Good luck to everyone else."

• Sha...
• Taken for less than 1 month
• May 26, 2018

Semaglutide for Type 2 Diabetes "My first week, I felt tired and had no energy. Mild, intermittent nausea. Guess that's the appetite suppressant part. After the first 3 days, I started getting quite a bit of stomach discomfort and diarrhea. Anything I ate or drank went right through me, as well as gas. Also, an unusual amount of belching. Hope this goes away soon and does not happen after every dose. I teach 4-year-olds, and it greatly affected my ability to do my job. My BS numbers are not much different."

• Ano...
• Taken for less than 1 month
• June 18, 2025

Semaglutide for Weight Loss (Obesity/Overweight) "Lost 10 lbs in 3.5 weeks, but the side effects mean I will be stopping. Diarrhea, vomiting, stomach cramps, headaches, bloating. Felt ill most of the time. Working and traveling problematic due to having to be close to a toilet!"

• SPM...
• Taken for 1 to 6 months
• October 3, 2024

Semaglutide for Type 2 Diabetes "This is week eight, and I feel terrible most of the day, stomach very uncomfortable, belch more than I have in my entire life. Hate it."

• All...
• Taken for 1 to 6 months
• March 15, 2023

Semaglutide for Weight Loss (Obesity/Overweight) "I took 4 shots of .25 Wegovy. The first shot had no side effects and no problems. The second shot was a little different. Mild upset stomach starting about 24 hours afterward with some stomach pain. This subsided within the third day. My appetite was suppressed, felt fuller for longer. In the third shot, I had no appetite with stomach pain that lasted two days, and also felt as if I were going to pass out. I drank orange juice and ate saltine crackers with peanut butter, which helped. The last .25 shot of Wegovy… I had lost 12 pounds by this shot. But within a day, I was projectile vomiting, upset stomach, extreme pain in my abdomen, chills, and dizziness. I was taken to the emergency room. I was diagnosed with colitis that had gone to sepsis. The doctor explained a side effect from Wegovy may cause gastrointestinal problems. Wegovy attacked my colon and in turn, sepsis formed. I will not continue this shot. So many side effects go with it. It does curve your appetite, but I would be very cautious."

• Cat...
• Taken for 6 months to 1 year
• March 8, 2023

Semaglutide for Type 2 Diabetes "I've been on Ozempic 0.25 mg since last March. Had a lot of stomach problems for the first 3 months and stopped for a month to calm my stomach. Lost 16 pounds in the beginning, but that has come to a standstill. I have noticed, besides stomach issues, mood swings, mild depression I didn't have prior, fatigue, and still ongoing stomach issues. I will probably stop. While it notes there are cardiology benefits, for me, it's just not worth the side effects. My advice is to make sure you keep in touch with your doctor and tell them how you are feeling."

• Sep...
• December 7, 2021

Semaglutide for Type 2 Diabetes "I have started Ozempic February 2020. I experienced severe stomach problems, constipation, my sense of smell became too sensitive. I couldn’t eat any kind of meat, eggs, or vegetables because the smell of them was revolting. Gradually, my intake was bread, cheese, and sweets, so weight loss was slow with a lot of carbs that were easy to digest. Since I had depression and previous reflux disease, my doctor kept telling me it is all in your head. I developed piles (hemorrhoids) because of the abuse of laxatives. Cramps in my large intestine were so severe that I begged my doctor I might have cancer. As I stopped Ozempic, I felt an enormous pressure leave my digestive system. Now I have another problem, I lost 8 kilos by Ozempic from February 2020 till October 2021. Two weeks after stopping Ozempic, I gained 4 kilos again, and I have an enormous appetite."

• Mar...
• Taken for 1 to 6 months
• March 19, 2021

Semaglutide for Type 2 Diabetes "I started Rybelsus with the 3 mg that the doctor gave me. Nausea started right away, but I could deal with it for the most part. When it was time to go to the 7 mg, I got scared of the thyroid cancer warnings and didn't continue with the drug. But my numbers started climbing after that again. So, a couple of months later, I started with the 7 mg that I had. I used it for a month, and the diarrhea, gas, and gurgling stomach increased each day. The diarrhea would wake me up in the middle of the night! I was having 5 to 6 bowel movements a day, I was afraid to leave the house. So, I saw the doctor and am going back to Trulicity, which I had fewer side effects with. I really wanted this medication to work for me as I need to lose a lot of weight. But the side effects are not worth it for me."

• She...
• Taken for less than 1 month
• June 20, 2018

Semaglutide for Type 2 Diabetes "The experience seemed to be consistent. I have Type II diabetes, and I'm trying to lose a little weight, actually a lot of weight. But I have chronic IBS, so when I started Ozempic and suffered bathroom issues, I wasn't sure it was the drug. But I started feeling really not great, stomach cramps, diarrhea, and even a little depressed? Two doses and I stopped. This is not for me..."

• Dix...
• Taken for less than 1 month
• June 11, 2022

Semaglutide for Cardiovascular Risk Reduction "Two days after my first injection, I had horrible sulfur burps that were making me feel sick. By that evening, I had horrific stomach cramps; by 11:30 pm, I had uncontrollable diarrhea! My prescriber advised me to eat six small meals a day and that the symptoms would improve with each injection. I left it twelve days before my next one (as I had a couple of social things I didn’t want to miss if it happened again) and thought at first it was better. A headache day one, nausea on day two, but sulfur burps again by day three. I got indigestion medicine, but it didn’t even touch it. That night, same again; cramps, diarrhea, more burps, and this time intense nausea too. I decided at that point it might not be for me! I really hope it helps some people lose weight, but don’t expect a quick easy fix! I actually felt fatter the whole time I was on it as I was so bloated and tender."