Semaglutide and Upset Stomach: What Users Say (Page 4)

• Car...
• Taken for 1 to 6 months
• March 2, 2025

For Type 2 Diabetes "1st week stomach discomfort (not too bad). 2nd week flatulence (sudden, uncontrollable, embarrassing). 3rd week sore throat, lots of phlegm, hard to swallow! 4th week, no appetite at all! Sudden diarrhea, no control, running out of me like water! I’m experiencing back pain in between my shoulders! Headache! 8-9 in pain! 10 excruciating!"

• Ros...
• Taken for less than 1 month
• February 17, 2025

For Type 2 Diabetes "This is my 2nd week on Ozempic. I was already having some issues (possibly the flu or COVID) when I first started Ozempic. By the time I got to see my doctor, I had already been sick for well over a week, so no testing was done. However, after talking to my diabetes doctor and taking my second dose, I am fairly sure the Ozempic is causing me some stomach issues. Nothing major, just an upset stomach and running to the restroom. I am currently taking 0.25 units a week. I am going to stay at this dosage for about 4 weeks and see how my system adjusts. It is very simple to use. I was surprised that there were needles with my pen, and they are so tiny. I wish the ones I use with my Lantus were this small. I was down 10 lbs when I went to the doctor, but I don't think it was just the Ozempic. Like I said, I hadn't been feeling well already and not eating very much because of it. But I will take what I can get!"

• Ros...
• Taken for less than 1 month
• February 17, 2025

For Type 2 Diabetes "This is my 2nd week on Ozempic. I was already having some issues (possibly the flu or COVID) when I first started Ozempic. By the time I got to see my doctor, I had already been sick for well over a week, so no testing was done. However, after talking to my diabetes doctor and taking my second dose, I am fairly sure the Ozempic is causing me some stomach issues. Nothing major, just an upset stomach and running to the restroom. I am currently taking 0.25 units a week. I am going to stay at this dosage for about 4 weeks and see how my system adjusts. It is very simple to use. I was surprised that there were needles with my pen, and they are so tiny. I wish the ones I use with my Lantus were this small. I was down 10 lbs when I went to the doctor, but I don't think it was just the Ozempic. Like I said, I hadn't been feeling well already and not eating very much because of it. But I will take what I can get!"

• Lad...
• Taken for less than 1 month
• December 8, 2024

For Type 2 Diabetes "This is week 1, and I’m already feeling the side effects: headaches, diarrhea, stomach ache, burping frequently that smells like rotten eggs. I get nauseous and gassy. I don’t have an appetite for food. I just started this medication, but I like its cleaning out my digestive system. I am reaching out to my healthcare provider to see what I can take to help eliminate the burping."

• Amb...
• Taken for less than 1 month
• May 20, 2024

For Cardiovascular Risk Reduction "I have been on Ozempic for 3 weeks now. I notice I get full faster and do not think of eating as much. I have had constipation with it even though I take a bowel softener and laxative. I had trouble yesterday and felt like my bowel almost got blocked up. Had not gone in two days and got severe stomach cramps. I finally did go with a lot of straining. Went a whole lot at one time. I have not lost any weight yet so far. I am going to check with my doctor on Monday. I am on 0.5 dose every week."

• Nik...
• Taken for 1 to 6 months
• May 7, 2023

For Weight Loss (Obesity/Overweight) "Checking in about my experience on Wegovy thus far. Tomorrow, Monday, May 8th, 2023, will be my second box of Wegovy 0.25 mg. So my 5th injection. I’ve lost 6 pounds since I first started. My biggest issue is diarrhea and nausea. I get occasional stomach cramping. Otherwise, I too have noticed that drinking more water seems to help. Lots of saltine crackers for me. The first week, I was scared to eat. I felt like I had the flu. It wasn’t a good experience for me. Then, gradually it let up, and by that first Friday, I felt like myself again, but still ate with caution. I have no taste! It’s odd. I know I’m eating, but it’s like I’ve lost my sense of taste. I will update after these 2 boxes are complete and hopefully will have a total weight loss that’s up to date. I don’t own a scale, lol."

• Tom...
• Taken for 6 months to 1 year
• April 13, 2023

For Weight Loss (Obesity/Overweight) "Started Wegovy in March 2022 with a goal of losing 50-75 pounds. I ended up losing a total of 85 pounds in about 11 months. I felt great upon taking the Wegovy. Only had mild headaches and mild stomach discomfort. I was not tired, I actually felt energized. However, by December, the nausea had reared its ugly head. I took Zofran, and it helped. I was able to stick it out with the nausea until February, at which time I stopped taking it. I could no longer live with the nausea. Since I stopped taking it, I have continued to suffer nausea, vomiting, and stomach pain. My doctor and I are still trying to find the source of this continuing issue. I love the weight loss, and I love Wegovy!"

• Sar...
• Taken for 1 to 6 months
• October 30, 2022

For Cardiovascular Risk Reduction "I have been on Ozempic for 4 months now for weight loss. Initially, I had some GI side effects (bloating and stomach upset), but after a few weeks that mostly went away. My appetite is low (which is the intended effect), and I have not been enjoying meat as much, but otherwise, I am happy with the way this is going. As of now, I lost 14 pounds. Would recommend this medicine to everyone trying to lose weight, except for the fact that it is quite expensive. I had trouble finding a prescriber because Wegovy, which is FDA approved, is backordered everywhere. And Ozempic is the same medication, but not technically approved."

• IBN...
• July 4, 2021

For Type 2 Diabetes "I have been on Ozempic for 3 weeks. Yes, it is making me lose weight, obviously because I'm so nauseated all the time that I can't eat. I have stomach cramps, constipation, headaches, body aches, and nausea so severe that sometimes I can't even lift my head up. I'm really trying to give it a chance since a once-a-week injection seems better than taking a bunch of pills. I just don't know how much longer I can suffer with the terrible nausea and stabbing stomach pains."

• Nei...
• April 16, 2021

For Type 2 Diabetes "Month 1, I was started on Ozempic at 0.25 mg and had very mild symptoms of bloating and reduced appetite. Month 2 & 3, uncomfortable. Stomach cramps, gas, and diarrhea probably for 4 days after injection. This can be really embarrassing in a small office. By the end of Month 3, I was feeling quite a bit better. At this point, my HbA1c was down to 5.2 from 9.4, I had virtually no diabetic symptoms. No blurred vision, no numbness in fingers and toes, and I was sleeping through the night without visits to the bathroom. And I lost 16 kilo in weight. Month 4 to 7. OMG. Increasing to 1 mg, the side effects are horrendous. Weight loss has stalled, though this is probably due to lockdown. The sickness and eggy burps are constant, and now my doctor says it will be at least 6 months before the side effects could be gone. But I have no diabetic symptoms, my HbA1c is pretty much normal, and I think the effort has been worth it. Not an easy journey, but worthwhile."

• Juj...
• April 30, 2019

For Type 2 Diabetes "Today marks day 6 on .5 of Ozempic, and I feel like it is working. I have a severe insulin resistance problem and haven't seen my numbers down into the 100's in way too long. My problems with Ozempic are that I can't eat. I'll take a few bites of whatever and get very nauseous and then a tummy ache. I did gain 20 lb in 2 months with the insulin use and feel like I'm losing the weight with Ozempic, but I'm a little concerned that I'll gain it back fast later. Oh, and constipation was settling in, but the only thing I've wanted to eat are cold prunes! Hahaha! So, problem solved. Burps? No, unfortunately, I can't burp! I have the feeling of wanting to, but nothing. Anyone else?"

• Ano...
• Taken for 1 to 2 years
• June 3, 2025

For Type 2 Diabetes "The first year I started using Rybelsus I lost 14 lbs in about 6 months. The 7th month I experienced an extreme stomach ache that made me lightheaded, and I fainted. I was visiting my daughter, and she found me near the bathroom on the ground. I reduced use from 14 to 7 mg, maintaining the loss for 6 months and then gaining 8-10 lbs. I went back on the 14 mg dose. 3 months later, I had another episode with a severe stomach ache, lightheadedness, and fainting that totally scared my husband in the middle of the night. I am generally a healthy eater and pretty active, just weight loss at my age is difficult. I am going to manage my A1C without drugs now."

• Jer...
• Taken for 1 to 6 months
• May 19, 2025

For Type 2 Diabetes "A little inconvenient due to the 30 min restriction, etc. Sugars down by 1.5, weight has not changed. Stomach is bloated and uncomfortable. Using 7 mg was hoping for better results and no stomach issues, which resulted in a wardrobe change. Regarding recommendation, I would say that I'm relatively happy with the glucose readings, but it's a big sacrifice regarding the stomach issues."

• Car...
• Taken for 6 months to 1 year
• May 6, 2025

For Type 2 Diabetes "It has worked for helping with my sugar. But all the restrictions for taking it are not easy to do. No food or drink for a half hour and only 4 ounces of water to take it make me not want to take it. And it is becoming less effective the longer I take it. Also, I have some common side effects. Have not lost any weight but have bloating and stomach distress, which I am prone to."

• Der...
• Taken for 1 to 6 months
• March 24, 2025

For Type 2 Diabetes "My doctor prescribed Ozempic for me at the beginning of January, starting at the .25 mg dose and working up to the 1 mg dose, which I have been on for a few weeks now. I have seen noticeable improvements in my glucose levels, which are now at a normal range, which they had not been for years. It was also prescribed to help with weight loss. I have not found it to be particularly helpful in this regard. I am losing small amounts of weight, but a lot of this has to do with a modified diet that is conducive to weight loss. The side effects I have experienced and continue to experience are stomach cramps and diarrhea, sulfur burps, some constipation, lightheadedness, and dizziness, which is the worst one for me. I was at the hairdresser today, and on leaving I almost passed out and had to go back inside to sit down, and there was a big fuss, etc., etc. It was very embarrassing and scary. I so desperately want to lose weight and think that it will eventually work for me, so I am going to keep taking it."

• OVE...
• Taken for 6 months to 1 year
• March 22, 2025

For Type 2 Diabetes "Lots of stomach pain, gas, lots of nausea. This occurs before eating on a lot of occasions. Also, lots of symptoms of GERD after increasing dose from 0.5 to 1 mg. Ozempic does work for my diabetes, but the cost is high. I was given this as a cardiac-friendly medicine, but the GERD and excessive bathroom and stomach issues get the heart worked up."

• ksy...
• Taken for 1 to 2 years
• February 5, 2025

For Type 2 Diabetes "It makes my stomach ache at night and gives me heartburn. I have to force myself to eat. I lost weight too fast, and the skin on my buttocks is loose. I still have type II diabetes."

• Mic...
• Taken for 1 to 2 years
• December 8, 2024

For Type 2 Diabetes "Been on Ozempic for 2 years. Now I experience stomach problems and gastro problems. Stomach pain, nausea, acid and bile issues. Diarrhea, gas, burping all the time. I think it's taking a toll on my body. It sucks. There are times I can't even function. I'm lost now. Sick of being sick."

• TLh...
• Taken for 6 months to 1 year
• November 19, 2024

For Type 2 Diabetes "Very hard for me to continue taking it. I have pretty bad stomach gas, heartburn, queasiness, and such, even after months at full strength."

• mew...
• Taken for 1 to 6 months
• August 27, 2024

For Type 2 Diabetes "I’m 63 F with T2 diabetes, and I started on Oz mid-May 2024. Symptoms: nausea, fatigue, GERD, sulfur burps, stomach cramping from severe constipation, constipation, feeling like I need to vomit, ringing in my ears has increased significantly, loss of appetite, reduction of inflammation, occasional migraines, feeling “off” most days, bouts of dizziness, and feeling faint, but blood sugar and blood pressure are normal, improved blood sugar readings, weight loss of 13 lbs. There are some perks: rheumatoid and osteoarthritis inflammation has lessened, though I still feel pain daily, it’s more tolerable. I take no painkillers but will take CBD as needed. Loss of appetite has led to a loss of 13 lbs so far, blood sugar improved so I’m confident that my A1C has improved also. I struggle with what to do: stay on for the inflammatory reductions, weight loss, and blood sugar improvement benefits, or quit because I feel sick most days, so I have no real pleasure in life anymore. No, I’m not depressed."

• Anonymous
• Taken for 1 to 2 years
• August 23, 2024

For Type 2 Diabetes "Severe diarrhea, very bad stomach gas, dizziness."

• Nad...
• Taken for 2 to 5 years
• May 20, 2024

For Type 2 Diabetes "My main problem (Side effects): change of food tastes, very noticeable loss of appetite, don't feel hungry anymore, and some stomach problems with pain."

• Fan...
• Taken for 1 to 6 months
• October 5, 2020

For Type 2 Diabetes "I have been on Rybelsus for 1.5 months. Can’t eat, and what I do eat makes me so nauseous that it all comes back up. I have lost 10 lbs, which is great, but if this upset stomach and throwing up do not go away, then it is not worth it. I’ll give it another week, but I think I will tell the doctor I am done. My sugar levels were high, and that is why he prescribed it to take along with Synjardy. Feeling sick all the time is not worth it."

• Sno...
• Taken for less than 1 month
• October 28, 2019

For Type 2 Diabetes "I just took my second dose on Friday of 0.5. I feel like garbage, no energy, tired, stomachache. I work out 4 days a week and I just can’t seem to find the energy to work out. I may stop using this drug because I’m so active and the past few days I can’t seem to do much. Appetite is gone completely. I don’t like that I have lost a few pounds but not the right way. I feel like I am starving myself, this is not for me."

• Bub...
• Taken for 1 to 6 months
• August 28, 2019

For Type 2 Diabetes "I have been on Ozempic for 9 weeks. I have not increased my dose due to stomach issues, I just stayed at .25. My A1C is starting to come down slowly. Have a 3-month check-in in 2 weeks. It was 10.2, then dropped to 9. I do feel weak and dizzy, and I dropped low in the morning and at night. Sometimes in the middle of the day. Yes, I am bloated. My weight was 220, lost 4 lbs, and I gained weight, so then 222. I have lost weight and I am down to 217. Hope this weight loss continues."