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Semaglutide and Headaches: What Users Say (Page 4)

Brand names: Ozempic, Rybelsus, Wegovy

Reviews for Semaglutide

Commonly mentioned side effects
  • Zed...
  • Taken for less than 1 month
  • May 8, 2019

Semaglutide for Type 2 Diabetes "I started this med last week at 0.25 and stopped my insulin and metformin for now. I told my doc I was scared that my blood sugar would drop too low. Last week, no major symptoms. I increased the dosage week 2 to 0.5, and I’ve been super sick with a headache. I’m going to drop my dosage next week back to 0.25 and see if the symptoms subside. I’m hopeful this will drop my blood sugar to where I can get off my insulin. We'll see what happens."

8 / 10
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  • deb...
  • Taken for less than 1 month
  • February 13, 2019

Semaglutide for Type 2 Diabetes "I started taking the .25 a week ago. The first 2-3 days, I had stomach pain, headache, and vomiting, none of which were bad. I took my second shot yesterday, and the gas was awful. The one thing that I really wanted to do was to lose some weight, and so far, I've lost 3 lbs. My appetite is slowly fading, but I have to watch myself because I'm still craving sweets at night. I have to make myself drink fluids, but luckily the one thing I did crave was Cokes, and I don't even think about them anymore. I love this med."

8 / 10
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  • Blu...
  • Taken for less than 1 month
  • January 2, 2019

Semaglutide for Type 2 Diabetes "I am on my 3rd week of Ozempic. So far, the only noticeable side effects have been fatigue, slight headache after injection, and it has stirred up my GERD a bit. It seems to be working with me. I am hoping all stays as it is now. Probably lucky on the side effects. I delayed taking for 2 weeks to wrestle with the possible side effects."

8 / 10
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Frequently asked questions

  • Ano...
  • July 7, 2025

Semaglutide for Type 2 Diabetes "I am not sure if it has been very much help, as my sugar levels have been running high and would need to have my A1C checked to see if it has lowered from my last visit. Have not experienced side effects like others: headache, stomach cramps, vomiting, or excessive diarrhea. Only experienced slight stomach cramps and diarrhea when I consumed greasy foods."

7 / 10
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  • Car...
  • Taken for 1 to 6 months
  • March 2, 2025

Semaglutide for Type 2 Diabetes "1st week stomach discomfort (not too bad). 2nd week flatulence (sudden, uncontrollable, embarrassing). 3rd week sore throat, lots of phlegm, hard to swallow! 4th week, no appetite at all! Sudden diarrhea, no control, running out of me like water! I’m experiencing back pain in between my shoulders! Headache! 8-9 in pain! 10 excruciating!"

7 / 10
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  • 65...
  • Taken for 1 to 6 months
  • March 1, 2025

Semaglutide "I'm on week 5 in a few days. Started at 0.25 cc inj. Mild nausea and headaches. 5' 10'', 186 initial weight. I'm 40 lbs overweight. I tried to eat right and exercise, but the weight was not budging. Just going up, and I'm very active outside. Today I'm down 10 pounds, it's a slow process for me, it seems. Very little appetite, and you can't eat much at one time or you feel terrible, bloated, nauseated, headaches... but I'm determined to drop another 30 lbs. I'm just surprised at how little I eat for a portion and am completely full... and still the weight clings on. I could not do it without this drug."

7 / 10
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  • fis...
  • Taken for 1 to 6 months
  • February 20, 2025

For Weight Loss (Obesity/Overweight) "After 7 weeks, I've lost 10 lbs. Minimal side effects, nausea occasionally, some headache, probably because I don't drink enough water. Definite decrease in appetite and full after very small portions. One would think the weight would have fallen off, but it's been about 1+ lbs a week. My dose has been .25 ml, on week 8 it is .50 ml. We shall see. I'm committed to losing 40 lbs, 30 lbs to go. I eat nutritionally rich foods, no junk, period, protein-rich fish, venison, and seafood, any kind of salad, but the weight has been so hard to drop. I'm not really hungry and late-night snacking desires, just gone, a thing of the past, so it's a kind of painless waiting game on this medication."

7 / 10
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More FAQ

  • GAF...
  • Taken for 1 to 6 months
  • January 28, 2025

Semaglutide for Weight Loss (Obesity/Overweight) "Wegovy was prescribed for weight loss, with a secondary potential benefit being a reduction in glucose levels and A1C. Began at minimal dose of 0.25 mg/0.5 ml. Had virtually no side effects. Also lost exactly 0 lbs. However, this first month included Thanksgiving, so a bonus that no weight was gained. Second month dose increased to 0.5 mg/0.5 ml. Side effects were primarily indigestion, some headaches, and very occasionally low blood pressure, but it included Christmas, so a positive was no gain. Month 3 increased dose to 1.0 mg/0.5 ml. In the first week at this dosage, can finally feel the appetite suppression. Side effects have included indigestion, burping, headache, and a bit of feeling sluggish. It has been very easy to administer the injections. I have been using the lower part of my stomach as the injection site, alternating from left to right side each week. So far, each injection has succeeded."

7 / 10
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  • Lad...
  • Taken for less than 1 month
  • December 8, 2024

Semaglutide for Type 2 Diabetes "This is week 1, and I’m already feeling the side effects: headaches, diarrhea, stomach ache, burping frequently that smells like rotten eggs. I get nauseous and gassy. I don’t have an appetite for food. I just started this medication, but I like its cleaning out my digestive system. I am reaching out to my healthcare provider to see what I can take to help eliminate the burping."

7 / 10
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  • WDL...
  • Taken for 1 to 2 years
  • August 26, 2024

Semaglutide for Type 2 Diabetes "Headaches, dizziness, blurred vision, low blood sugar when used with Glipizide."

7 / 10
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  • BER...
  • Taken for 6 months to 1 year
  • August 16, 2024

Semaglutide "In the beginning, I was taking 7 mg, it made me hungry and fatigued. After 6 months, I moved to 14 mg due to weight gain. After taking it for a week, it helped my hunger pangs. I experienced headaches behind my eye and head, fatigued, no energy. I have contacted my doctor for advice. Ease of making it part of your daily routine is easy."

7 / 10
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  • Ser...
  • Taken for less than 1 month
  • July 25, 2024

For Weight Loss (Obesity/Overweight) "I had a headache for the first 4 days... I guess it's been okay since then. Lots of nausea, and I can't stand much food, but I guess that's the whole idea."

7 / 10
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  • cat...
  • Taken for 1 to 6 months
  • June 23, 2023

Semaglutide for Type 2 Diabetes "I have been taking Rybelsus for about 3 months. I have had nausea and weight loss. My blood glucose level is much better. It's even sometimes low. I now wear a continuous glucose monitor. I have random nausea after taking the medication in the mornings and can experience nausea during the day if I eat too much or greasy food. I think this is what causes some of the weight loss. You just don't want to eat if you have nausea. I do occasionally get a headache and constipation if I don't drink lots of water. The drug makes me not want to eat, but it also makes me not want to drink, so I have to force myself to drink water, or I get dehydrated and constipated. This drug makes me forget to eat or drink. It's strange. The good side effect is weight loss. Bad is nausea. My insurance does cover it."

7 / 10
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  • Jea...
  • Taken for less than 1 month
  • June 7, 2023

Semaglutide for Type 2 Diabetes "Nausea, bad acid reflux at night, nightmares, headache every morning, constipation, chills, fatigue. Just started a week ago. Blood sugar levels in the 80s and 90s. Have lost no weight. Zero appetite. Blurry vision."

7 / 10
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  • Tom...
  • Taken for 6 months to 1 year
  • April 13, 2023

Semaglutide for Weight Loss (Obesity/Overweight) "Started Wegovy in March 2022 with a goal of losing 50-75 pounds. I ended up losing a total of 85 pounds in about 11 months. I felt great upon taking the Wegovy. Only had mild headaches and mild stomach discomfort. I was not tired, I actually felt energized. However, by December, the nausea had reared its ugly head. I took Zofran, and it helped. I was able to stick it out with the nausea until February, at which time I stopped taking it. I could no longer live with the nausea. Since I stopped taking it, I have continued to suffer nausea, vomiting, and stomach pain. My doctor and I are still trying to find the source of this continuing issue. I love the weight loss, and I love Wegovy!"

7 / 10
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  • IBN...
  • July 4, 2021

Semaglutide for Type 2 Diabetes "I have been on Ozempic for 3 weeks. Yes, it is making me lose weight, obviously because I'm so nauseated all the time that I can't eat. I have stomach cramps, constipation, headaches, body aches, and nausea so severe that sometimes I can't even lift my head up. I'm really trying to give it a chance since a once-a-week injection seems better than taking a bunch of pills. I just don't know how much longer I can suffer with the terrible nausea and stabbing stomach pains."

7 / 10
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  • Mrb...
  • Taken for less than 1 month
  • February 21, 2020

Semaglutide for Type 2 Diabetes "I have been on it for a week and noticed headaches, and my stomach feels like it burns. I also had diarrhea a few times, but now I noticed when I poop, it burns every single time!!! Anyone else?"

7 / 10
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  • Dan...
  • Taken for 1 to 6 months
  • July 4, 2019

Semaglutide for Type 2 Diabetes "Two days after the injection, I get a pretty bad headache, indigestion, and a bloated feeling that lasts the day. This week (6th shot) has been different. It’s the second week the dose was raised from .25 mg to .5 mg. I felt like I had to throw up. The indigestion, burping, constipation, sore muscles, aches, and heavy sweating all felt like I had a horrible flu. I stayed home from work. I went back to work today, when I normally get the headache, and had heavy sweating, burping, indigestion, cold clammy skin, bloating, diarrhea, and depression and anxiety (years since I had either one). Tonight I still have bloating, wrists and shoulders sore, and indigestion with burps. My neck is really stiff. The normal headache has started with a little dizziness. I am still debating what to do as this has been an effective medicine. My blood sugar has gone from 290 to 90 to 140 when I check it. I have lost weight as well."

7 / 10
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  • Ano...
  • Taken for 1 to 6 months
  • June 20, 2025

Semaglutide for Type 2 Diabetes "I hate the side effects, fatigue and headaches, and irritable. Hard to do things."

6 / 10
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  • Lea...
  • Taken for less than 1 month
  • March 16, 2025

Semaglutide "Just had 0.5 injected yesterday, and my head hurts, it somehow triggered my migraine. Because of this, monitoring high blood pressure."

6 / 10
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  • Rev...
  • Taken for less than 1 month
  • January 21, 2025

Semaglutide for Weight Loss (Obesity/Overweight) "It has only been a week since my first injection. The only noticeable effect is the headache."

6 / 10
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  • Avi...
  • Taken for 1 to 6 months
  • July 16, 2024

Semaglutide for Weight Loss (Obesity/Overweight) "I am 58, have IBS-D, no gallbladder, GERD, and am 60 lbs overweight. This is my second attempt at taking Wegovy. The first attempt was disastrous! I didn't make it through the first week before I was hit with diarrhea, nausea, acid reflux, dizziness, cramps, and had headaches. I missed four days of work and went to ER twice. The doctor did tell me to stop taking this, but I honestly did not think it was the Wegovy (I had not done any research on side effects). Once I got back to my normal state of digestive issues, I became proactive. I started back on Wegovy (.25 lowest dose) 6 weeks ago, but now I take a dose of Pepto-Bismol daily (twice a day the day of and day after the shot) and I take an OTC daily antacid. I still get mild side effects (nausea, headache, and fatigue) the day after the shot or if I overeat. I have not lost any weight at this dose so I am going up to the .5 dose next week. As others have said - everyone will react to this med differently."

6 / 10
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  • Mar...
  • Taken for 1 to 2 years
  • June 5, 2024

For Weight Loss (Obesity/Overweight) "Terrible. Headaches, nausea. So bad I had to miss work. It was great initially, but now the side effects are terrible."

6 / 10
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  • blh...
  • Taken for less than 1 month
  • May 31, 2024

Semaglutide for Weight Loss (Obesity/Overweight) "First dose 0.25mg, had slight stomach pain/discomfort. Later that same night, my appetite disappeared. Just seeing a fast-food commercial on TV made me feel nauseous. I thought if that's the worst of the side effects that affect me, then I'll be very happy with that. By the next day, stomach pain and nausea increased. By 4:00 am, BAM! Diarrhea, severe stomach pain, projectile vomiting, headache, chest pain, severe itching mainly on the palms of my hands and arms. I truly thought 'this must be what it feels like to be poisoned!' I was scared. It is now the next day and I feel fine. A little tired from lack of sleep from feeling so sick. I think I will do my second dose next week...but I'm quite nervous of a repeat of feeling like I was dying from the stomach pains and vomiting. Will I continue with this drug?...jury is still out! On the positive side, I've already lost 5 pounds; but of course, I can't & don't want to eat, too much nausea and vomiting."

6 / 10
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  • Mom...
  • Taken for 1 to 2 years
  • June 24, 2023

For Type 2 Diabetes "The medication worked well. In the beginning, it definitely delivered great results. A1C was down, weight followed, however, the gallbladder problems began after about 9 months. Constipation, clay stool, nausea, headache, flu-like symptoms. I just stopped taking it. Because I have developed healthy eating habits, vegetarian, I am doing well. Just got diagnosed with Sjogren's disease, not sure if Ozempic had something to do with it?"

6 / 10
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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.