Semaglutide and Headaches: What Users Say (Page 2)
Brand names: Ozempic, Rybelsus, Wegovy
Reviews for Semaglutide
- Hap...
- Taken for 1 to 6 months
- June 10, 2020
Semaglutide for Type 2 Diabetes "I've been using this off-label for weight loss for 3 months after consistent diet and exercise, and allegedly controlled Hashimoto's left me frustrated that I still couldn't lose weight. This drug has been amazing. I do still suffer from occasional headaches that are moderate to severe, and if I eat something I 'shouldn't,' there are usually digestive repercussions. But I'm down 15+ pounds in 3 months without any real change to my prior (very good) lifestyle. I lean into the days I'm not hungry and allow myself to eat on the days that I am. It is expensive, but there are great coupons. I will stay at the 0.5 dose until I reach my goal weight and then try to taper off."
- Kar...
- Taken for 1 to 6 months
- March 10, 2020
Semaglutide for Type 2 Diabetes "This is my 8th week and using 0.5. I lost 12 lb and I have more energy now so I go to exercise as well now. Only on the first week I have heavy headache but it was gone on my second week. I thought of stopping it after the first week due to the headache but luckily I continued and I am having a happy life now."
Frequently asked questions
- Ozempic Side Effects to Watch For
- Wegovy vs Ozempic: Which is Right for You?
- Tirzepatide vs semaglutide: How do they compare?
- Which GLP-1 drug is best for weight loss?
- Anonymous
- February 7, 2020
Semaglutide for Type 2 Diabetes "My doctor put me on Ozempic to lower my blood sugar and A1c, as every time I check my blood sugar it’s extremely high in the 200s and 300s. So that is why my doctor put me on Ozempic. At the beginning of the year, before the medication, my A1c was 10.8, and my blood sugar was in the 200s. Five weeks later, I went to the doctor this week and got my sugar checked, it was 72. I couldn’t believe it, plus my A1c is 8.2, and I lost 5 lbs in just a short period. I take my shot every Sunday, .25. The day after I take the shot, I do experience some nausea, headaches, and constipation, but it’s only for one day, and it’s worth it for these low numbers. I was scared to take this new drug because I already take metformin 1000 mg once a day, but I’m so happy my doctor introduced me to this medicine. If you guys can get through the side effects, keep taking it, this medicine really works."
- Sen...
- August 29, 2019
Semaglutide for Type 2 Diabetes "I've been taking Ozempic for about 2 months to lower my Diabetes 2. It's been great, my numbers were 200 to 300, they are now 100-134. My A1c was 9.8, it is now 6.1, and I've lost 12 lbs and still losing. I'm also taking Synjardy XR, a combination of (Metformin & Jardiance), my numbers are great. I eat extremely less on the Ozempic. My only side effect has been an occasional headache, but nausea was brutal. I was getting very nauseated after eating and taking Synjardy XR until I heard about ZOFRAN. Let me just say, if you have nausea and are taking Metformin with Ozempic, PLEASE ask your doctor for a prescription of ZOFRAN (I got the generic ONDANSETRON 4mg). I take it 20 minutes after I eat and have taken my metformin. I NO LONGER get nausea. Zofran will definitely help with nausea if you're feeling sick. You'll thank me later."
Are you taking this medicine?
Your review helps others make informed decisions.- Mon...
- Taken for 6 months to 1 year
- August 15, 2019
Semaglutide for Type 2 Diabetes "Started Ozempic in January 2019. I have lost 24 lbs, and my A1C has gone down. My appetite has been cut in half. The only side effect I have had was in the beginning: slight headaches. Those have gone away. If I overeat, I’ll get a sour stomach. But other than that, I didn’t get those bad effects I have been reading about. Definitely happy with the results."
- Tme...
- May 26, 2019
Semaglutide for Type 2 Diabetes "I love this medication. I've been on the med since 3/8/2019. 11 weeks. I have lost 27 pounds and feeling good. I have learned to switch the spot where I give the shots. I find when I give them in the stomach only, I get constipated. And the day after giving the shot, I get a headache. I sleep with two bottles of water by my bed daily. If I don’t drink it at night, in the morning I do."
More FAQ
- Why am I not losing weight on Ozempic?
- Does Ozempic cause muscle loss and how to prevent it?
- How much does semaglutide cost?
- How does semaglutide work for weight loss?
- Bak...
- Taken for 1 to 6 months
- May 24, 2019
Semaglutide for Type 2 Diabetes "I have been on Ozempic for 3 months now, and I find this drug works like none I have tried before. The first 6 weeks were rough: burping, headaches, fatigue, nausea, but I stuck it out. I’m so glad I did. My A1C has gone from 8 to 6.8 in three months. I have lost 20 pounds, going from 180 to 160 lbs. My daily sugars have seen a vast improvement. The major thing I have noticed after being on the drug for this long is that recovery time after eating high-carb or high-sugar foods is back to normal. Appetite is still lacking, but it’s mostly an aversion to ‘bad’ food. I can no longer sit and eat an entire burger, it’s just way too much, but a healthy salad, I can eat the whole thing! I have seen major benefits from this drug. I have way more energy and no more 3 pm crash. Tips while adjusting to the drugs: Tums, Gravol, lots of sleep, light healthy meals, and remember to drink water! Also, I found injecting Ozempic in the hip lessened the symptoms for the first while."
- Ver...
- Taken for less than 1 month
- April 24, 2019
Semaglutide for Type 2 Diabetes "Started taking this Ozempic 0.25 dose injection for my first week. On 04/17/19, I have lost a total of 4.5 pounds so far. I am on my second week of Ozempic. The first week I didn’t have stomach pain, headache, or any side effects. But I notice that my appetite had a big change. I am not hungry all day. I am eating small meals now. I have been drinking more water than normal, but after reading all the reviews, I was really scared too. I wasn’t sure if this was going to be the right medicine for me. But it works!!! No side effects yet!"
- Mim...
- January 18, 2019
Semaglutide for Type 2 Diabetes "Started taking this drug 4 weeks ago. I got just a light headache at first, then I'm fine. My appetite is definitely under control. No cookies, junk food, etc. for the last 30 days, and I have lost 17 pounds! I take .50 per week! Wow!"
- Mae...
- Taken for 1 to 6 months
- June 26, 2025
"Constant headache, tiredness, lack of energy. I didn’t want to go out or do anything with family or friends, but mainly because I had constant headaches that were not being relieved by my prescription medicine."
- Ano...
- Taken for less than 1 month
- June 2, 2025
Semaglutide for Weight Loss (Obesity/Overweight) "I am just 10 days in having been prescribed it in the NHS via Oviva. The run-in to receiving the meds has been really useful. I think success is dependent on coaching and mindset and lots of hints and tips via their app on how to get your balance of carbs, protein, and veg right. So far, minimal side effects at 0.25mg just a bit of nausea and headaches. First week, 4lb loss, which I am really pleased with. This is a two-year journey for me, so slow and steady is key I think."
- Ano...
- Taken for 1 to 6 months
- April 8, 2025
Semaglutide for Weight Loss (Obesity/Overweight) "I am in week 10/injection 2 of 1 mg and taking Wegovy for weight loss. I started at 142 kg and am down to 132 kg, which is wonderful. My goal weight is 115 kg as I'm tall and solid build. The side effects, nausea, fatigue, headaches, and some bowel upsets tend to dissipate 3 days after the injection. Avoid big meals and heavy/fatty foods in particular to minimize side effects. Not enjoying food and the social side can be a bit tough, but the results far outweigh any downsides. You actually save money overall due to eating less. I intend to stay the course and highly recommend this life-changing experience."
- Wor...
- Taken for 6 months to 1 year
- February 25, 2025
Semaglutide for Weight Loss (Obesity/Overweight) "Beginning weight was 234 and began at 0.25 in June 2024, and just began 2.4 today at 177. Been going up very slowly, but weight loss has slowed way down. Still have 17 pounds to lose, but prefer 27 more. Have gone from 2XL/Size 22 to size 14. Have dealt with nausea, headaches, occasional constipation/diarrhea, depending on what I eat. Small meals, five times a day, plus drinking lots of water is key. I get extremely tired the day or two after taking the shot. I take the shot at night, hoping to be at my goal weight by the end of May 2025. 63-year-old woman and all blood work now within normal limits."
- Apr...
- Taken for 1 to 2 years
- December 31, 2024
For Weight Loss (Obesity/Overweight) "I took a very low dosage of .25, and I lost 30 pounds over the course of six months. The first few days of taking it, I would have a headache and would be very tired, but that eventually went away."
- Flo...
- Taken for less than 1 month
- December 16, 2024
Semaglutide for Weight Loss (Obesity/Overweight) "I am on my 3rd injection today of Wegovy. Started at 234.5 pounds. Down 8 so far. I'm not sure it's all Wegovy, as I've been able to lose 40 lbs on my own 2 separate times, and I am still doing the things that gave me that success before. Eating close to 1200 a day calories, walking 10,000 steps a day, and lowering alcohol consumption. Still, I do believe it is helping me get a good start and get my mind right. The fear of the side effects is what is probably keeping me in line. So far though, I've only had headaches and fatigue a day or so after the shots. Otherwise, no other side effects, so I am pleased so far with how things are going."
- Sha...
- Taken for 1 to 6 months
- October 28, 2024
Semaglutide for Type 2 Diabetes "Type II diabetic with kidney disease. Been on Ozempic 18 weeks, and at 2.0 for 4 weeks. I felt great at 1.0, but not at 2.0. Lethargy and headaches non-stop now. Will see Dr. to go back to 1.0 after blood work. Good news: A1C went from 7.3 to 6.5. Glucose now close to normal range. Previously was between 260-335. Kidney function increased from 30-37. Lost 44 lbs. I am 62 and on disability."
- Jen...
- Taken for 1 to 2 years
- October 22, 2024
For Weight Loss (Obesity/Overweight) "I started taking semaglutide in April of 2023 and was at my highest weight ever (230 lb) and perimenopausal. I have never really struggled with weight gain until my 40s, and when I hit 230, I was seriously considering if I would be a candidate for bariatric surgery, but thankfully someone suggested semaglutide. I did experience side effects-nausea, headache, some constipation-but I have lost 70 lbs, and I think taking semaglutide was worth it."
- Bre...
- Taken for 1 to 6 months
- June 14, 2023
Semaglutide for Weight Loss (Obesity/Overweight) "I began using Wegovy injectable semaglutide exactly 8 weeks ago today and have had very few symptoms, until the 7 1/2 week mark. At first, my nose ran continually, but that was somewhat manageable with Robitussin (recommended by the pharmacist) for the cough it caused. At dinnertime, at the 7 1/2 week mark, fatigue hit very hard. We were on a trip, and I could barely walk to get back to the hotel and fall in bed. This continued for 48 hours with no desire for food or drink, except ice water. I slept for 5 or 6 hours and awoke with a headache, which lasted the rest of the night. Strange because I do not get headaches. Thankfully, we were headed home at that point, and I slept in the car most of the day for two days. I am much improved and can function somewhat, but not back to normal yet. I am due to double my dose today, but the medication not available for a while due to high demand. Easy to use and have lost 10 lbs in 8 weeks."
- Mac...
- Taken for 1 to 6 months
- June 13, 2023
For Weight Loss (Obesity/Overweight) "I experienced frequent headaches, fatigue, constipation, anxiety, mild depression, lack of interest in activities, aversion to alcohol, and dry mouth. I did have a 14-pound weight loss over 3 months. It is a slow and steady loss, which is reasonable."
- Slo...
- Taken for 1 to 6 months
- April 3, 2023
Semaglutide for Weight Loss (Obesity/Overweight) "Starting week 9 with the second injection of 1 mg. I have lost 24 pounds in 8 weeks. The side effects happen about 3 - 4 days a week. The first weekend on 0.25 mg was the worst! I really thought I needed my last rites! I have had headaches, nausea, vomiting, and bowel issues but not like the first-week episode. I try to eat light the day of the shot and take it at night because it makes me tired. You have to stay positive and just buy meds that will help with side effects because the side effects will probably always happen a couple of days a week. Try to drink 1/2 gallon of water a day and stay away from red meat, fried food, fast food, (most) dairy and sugar. If you don't, you will feel sick from eating that stuff. Also only eating one cup of food every couple of hours has made a huge difference in the nausea. Stock up on SF ice pops and SF Gatorade. I am so grateful that I got Wegovy with my insurance and when I want to quit, I just remember how many people would love the opportunity."
- All...
- Taken for 1 to 6 months
- March 21, 2023
Semaglutide for Weight Loss (Obesity/Overweight) "On December 19, 2022, I saw my medical provider and requested a prescription for Ozempic. She agreed that at 5’3” and weighing 192 lbs, it would be a good option for me. I started Ozempic on January 3, 2023. The first time I weighed myself after starting Ozempic was at the beginning of February, and I weighed 179 lbs. Through February, my weight bounced between 181-175, then I lost another 5 lbs in the first two weeks of March. I’m hoping to reach 160 by mid-April. My weight goal is 130-135. I am very happy with Ozempic’s effect on my weight loss. I have had assorted side effects. I had two days of extreme headaches after my first dose, but I’ve only had mild headaches with dosage increases since. My stomach is mild to moderately upset most of the time, and most of the time I don’t have much appetite. I’m at a 1 mg/week dosage now, and I’ve started having a lot of bad-tasting burps, but constipation is by far my worst side effect. I don’t know if I would have bowel movements without laxatives."
- All...
- Taken for 1 to 6 months
- March 21, 2023
Semaglutide for Weight Loss (Obesity/Overweight) "On December 19, 2022, I saw my medical provider and requested a prescription for Ozempic. She agreed that at 5’3” and weighing 192 lbs, it would be a good option for me. I started Ozempic on January 3, 2023. The first time I weighed myself after starting Ozempic was at the beginning of February, and I weighed 179 lbs. Through February, my weight bounced between 181-175, then I lost another 5 lbs in the first two weeks of March. I’m hoping to reach 160 by mid-April. My weight goal is 130-135. I am very happy with Ozempic’s effect on my weight loss. I have had assorted side effects. I had two days of extreme headaches after my first dose, but I’ve only had mild headaches with dosage increases since. My stomach is mild to moderately upset most of the time, and most of the time I don’t have much appetite. I’m at a 1 mg/week dosage now, and I’ve started having a lot of bad-tasting burps, but constipation is by far my worst side effect. I don’t know if I would have bowel movements without laxatives."
- Anonymous
- Taken for less than 1 month
- August 23, 2022
Semaglutide for Cardiovascular Risk Reduction "Started at 0.125. The first two weeks, I experienced dizziness and nausea. My nausea was mainly at night, I would dream about being sick. I was slightly less motivated than normal. I'm normally a healthy eater, but eat big portions. Not sure if it was the nausea, but I find myself eating slightly less healthy but smaller portions (for example, I used to eat big salads, and that sounds gross to me, so I might eat a small portion of pasta/bread, etc. I have lost 6 pounds in almost 4 weeks, but I am on the smaller side. I am not sure if it is related or not, but I have experienced more frequent headaches since beginning, and I have also experienced more side effects from alcohol (normally, I can have a few glasses of wine without a hangover, but I feel slightly hungover if I have more than one drink). I am excited to continue, and I would recommend trying! Just know the nausea does stop!"
- Chu...
- Taken for 1 to 6 months
- July 30, 2022
Semaglutide for Weight Loss (Obesity/Overweight) "Started Wegovy February 28, 2022, at 257 pounds. July 28, 2022, at 205 pounds on the 2.4 ml dose. Side effects at low dose were headaches, stiffness, fatigue, indigestion. 2.4 dose caused extreme gas. Sometimes I stayed an extra month on a dose because of side effects, but you get used to them. Sometimes side effects come the next day or 5 days later. Completely stopped drinking alcohol because it makes me very sick while taking Wegovy."
See also:
Mounjaro
Mounjaro is used for type 2 diabetes to help lower blood sugar levels. Mounjaro has also been shown ...
Rybelsus
Rybelsus tablets are used to improve blood sugar control in adults with type 2 diabetes, and may ...
Ozempic
Learn about Ozempic (semaglutide) for type 2 diabetes treatment, weight management, cardiovascular ...
Zepbound
Zepbound (tirzepatide) is an FDA-approved weekly injection for weight loss and obstructive sleep ...
Wegovy
Wegovy (semaglutide) an FDA-approved weekly injection for weight loss and to reduce heart risks ...
Victoza
Victoza helps control blood sugar levels and reduce the risk of serious heart problems in people ...
Saxenda
Saxenda (liraglutide) injection is used for weight loss in obese or overweight patients. Includes ...
Alli
alli blocks the absorption of some of the fat that you eat and is used to treat obesity. Learn ...
Amphetamine
Amphetamine is a stimulant and is used to trat narcolepsy and attention deficit disorder. Includes ...
Tirzepatide
Tirzepatide is a once-weekly injection used for weight loss, sleep apnea, and type 2 diabetes ...
Are you taking this medicine?
Your review helps others make informed decisions.More about semaglutide
- semaglutide consumer information
- Check interactions
- Compare alternatives
- Reviews (2,714)
- Latest FDA alerts (5)
- Side effects
- Dosage information
- Patient tips
- During pregnancy
- Support group
- Drug class: GLP-1 Agonists (Incretin Mimetics)
- Breastfeeding
For Type 2 Diabetes "This has been amazing for weight loss! How are more people not taking this? I’m now eating like a normal person instead of like a pig. Had a little bit of a headache at first, but if that is what I have to put up with rather than running on a treadmill, sounds like a good deal."