Semaglutide and Fatigue: What Users Say (Page 5)

• Cor...
• Taken for 1 to 6 months
• June 9, 2023

Semaglutide for Weight Loss (Obesity/Overweight) "Last night, I had my first injection of 1 mg strength (week 3). I have gastrointestinal issues of bloating, eructation, diarrhea, and abdominal pain, LUQ 3-4/10 pain. It feels like a stomach virus, chills, but afebrile. Fatigue and anorexia. Only lost 5 lbs, but think it’s due to significantly reduced food intake."

• Ley...
• Taken for 1 to 6 months
• June 3, 2023

Semaglutide for Weight Loss (Obesity/Overweight) "From the initial starting dose until I went up to 1 mg, the whole 6 months was a roller coaster of nausea, headaches, and uncontrollable vomiting. The nausea was always followed by throwing up 5-7 times per day. If I ate or drank anything with too much sugar (including fresh orange juice), then I would throw it up within 30 mins. The sulfate mouth smell, along with the vomiting, was difficult and embarrassing. Exhausted and tired feeling, along with feeling depressed and hating/disgusted by food, is how I felt. I did lose about 8 kgs before moving on to Saxenda. Get ready for Ozempic to destroy your life for a few months if you want to lose weight with it."

• Apr...
• Taken for 1 to 6 months
• August 25, 2021

Semaglutide for Type 2 Diabetes "I have been on Ozempic for 20 weeks now, and I still experience bloating, flatulence, nausea, and fatigue. My A1C went back to normal, but I feel sick all the time. My most horrible side effect is the rotten egg smell of my burps. I am also taking Toujeo and Janumet."

• Bra...
• Taken for 1 to 6 months
• July 31, 2021

Semaglutide for Type 2 Diabetes "I have been taking Ozempic for about 4 months now. Haven’t had really bad side effects, but sometimes I feel just exhausted and somewhat out of breath. I also have muscle aches and fatigue. Not lost a lot of weight, maybe 2 lbs. I keep hoping. Does anyone else have similar side effects? Good luck and all the best results for everyone."

• Sus...
• Taken for less than 1 month
• April 3, 2021

Semaglutide "For weight loss. I started .25 injection Ozempic for weight loss as I was kind of stuck losing weight. It works great for weight loss, and I absolutely have no cravings at all and don't like to eat any food. However, I feel nauseous, and I have low energy, which is not a great feeling as I am usually very active and energetic. I will give it a longer try as it works for me losing weight, as I already lost 4 pounds. Mind you, before I started, I was on a higher fiber diet. Time will tell, I just don't like the way I feel."

• Chr...
• Taken for 1 to 6 months
• January 9, 2020

Semaglutide for Type 2 Diabetes "I am 70, and I have been using Ozempic for over 5 months. After having horrible nausea, things have gotten better. I have to use samples as the cost is greater than I can afford. Now, my joints are paining, reflux, and low energy. My A1c is better, and I have lost a little weight."

• Swi...
• Taken for 1 to 6 months
• May 13, 2019

Semaglutide for Type 2 Diabetes "Started on Ozempic 5 months ago for diabetes 2. Started at 0.25, then 0.50, now at 1.00, and so far I lost weight - 35 lbs. But I’m feeling really fatigued, dizzy, and occasional stomach ache, diarrhea, and my eyesight has changed. Great drug for lowering A1C and losing weight, but the side effects are horrible. I think I’m done taking this drug. Side effects are getting worse."

• Ano...
• Taken for 1 to 6 months
• July 25, 2025

Semaglutide for Cardiovascular Risk Reduction "BP and blood glucose levels are the lowest they have been in a decade while taking 0.25 mg weekly for a month. However, abdominal pain, nausea, loss of appetite, reflux, and loss of energy have been persistent and, at times, debilitating since starting on the drug. Additionally, heart rate is running 15-20 bpm higher constantly. Not sure the gains outweigh the loss of quality of life."

• joh...
• Taken for 1 to 6 months
• June 16, 2025

Semaglutide for Type 2 Diabetes "Reduced blood sugar from 10 to 7.1. Killed my hunger completely, no more food cravings. Side effects became disabling, had to discontinue using. Became bloated, nausea was bad, 1st time I have vomited in 50 years, fatigue, constipation, going to the emergency room as no doctors available to help."

• RNJ...
• Taken for less than 1 month
• February 16, 2025

Semaglutide "Everyone is different. I really wanted it to work for me, but I cannot tolerate it. At first, I thought it was magic, it took away all food cravings, and I could no longer eat large meals. I tried to stay hydrated and eat a high-protein diet, but I still felt very fatigued. I also experienced low blood sugar and would have to force myself to eat to make the shakes go away. Even my favorite foods no longer taste good, and I have felt depressed. I cannot wait for it to clear my system. Just know some can tolerate the side effects, and some cannot."

• Odi...
• Taken for less than 1 month
• May 22, 2023

Semaglutide for Weight Loss (Obesity/Overweight) "This is my third week, and I feel absolutely horrid! I have constant dizziness, extreme fatigue, and generally feel like crap. I don't think I will continue. It's not worth it to lose maybe 20 lbs, but I can't get out of bed and function. I am tired of feeling like death warmed over. Unfortunately, because it is controlling my appetite, I'm full after a few bites. I am on a 25 mg dose."

• Cat...
• Taken for 6 months to 1 year
• March 8, 2023

Semaglutide for Type 2 Diabetes "I've been on Ozempic 0.25 mg since last March. Had a lot of stomach problems for the first 3 months and stopped for a month to calm my stomach. Lost 16 pounds in the beginning, but that has come to a standstill. I have noticed, besides stomach issues, mood swings, mild depression I didn't have prior, fatigue, and still ongoing stomach issues. I will probably stop. While it notes there are cardiology benefits, for me, it's just not worth the side effects. My advice is to make sure you keep in touch with your doctor and tell them how you are feeling."

• Pat...
• Taken for 1 to 6 months
• August 29, 2022

Semaglutide for Type 2 Diabetes "I have been taking this drug for about 8 weeks, starting out with the 0.25 dose and now on the 0.5 dose. I have felt miserable the whole time, with nausea similar to pregnancy and with a revulsion to most food and smells of food cooking. Definitely low energy. I have lost weight, and I haven’t had my A1C checked since I started. I will see my doctor in a couple of weeks and will be telling her that I can’t continue to live this way. I’m 75 years young and don’t want to live the rest of my years feeling bad! Unusual, hiccup-type burps, coming out of nowhere and no appetite. Convenient once-a-week administration."

• Pri...
• Taken for less than 1 month
• May 20, 2022

Semaglutide for Type 2 Diabetes "My doctor put me on this because I was pre-diabetic, and he said I was insulin resistant. Since I’ve been taking it, I’m not as hungry, but my head hurts, and I always feel dehydrated, and so I’m peeing all day. I feel short of breath, and my chest has been feeling pains. I’m also experiencing constipation and constant light-headedness, and I’ve only been on it for 2 weeks. I may give it another 2 weeks, but not sure if the side effects are worth all this. I feel no energy, and my legs are always sore, and I’m so tired all the time. My way of living has suffered because I’m too tired to do anything and feel yuck all the time. Trying not to be frustrated because if this doesn’t help me, he wants to put me on Jardiance, but I hear so many horror stories about that one. This one isn’t as great as everyone said it would be, so who knows, maybe Jardiance will be better for me."

• Geo...
• Taken for less than 1 month
• February 23, 2022

Semaglutide for Type 2 Diabetes "Been on Rybelsus 3 mg for 16 days. Sugars have improved somewhat already, and weight down about 5 pounds, unexpected. BUT, no appetite, stomach feels full all the time, hard to even drink enough water each day because stomach so uncomfortable. Constipation that is not very responsive to Miralax. Cold hands. Some nausea. More heartburn than usual. Increased fatigue. And the worst is: dizziness and/or vertigo and a feeling of weird fullness in my head along with tinnitus. What the heck? Given the high cost, and that I've all these effects even before going on the 7 mg dosage, I don't think it's worth it."

• kit...
• Taken for less than 1 month
• August 2, 2021

Semaglutide for Type 2 Diabetes "Rybelsus made me really sick. I didn't realize it until a couple of days ago. I thought I had a virus. I was practically leaning on the wall every day, trying to pull myself out of work to the car. Last week, I spent a lunch time lying on my office floor and then just left early. It is more than the nausea, it was fatigue, significant dehydration, confusion, dizziness, headaches... I'm still feeling sick after 2 days of not taking it. I just read that it can take a couple of weeks to get out of your system."

• Kom...
• Taken for less than 1 month
• November 27, 2019

Semaglutide "Oh boy. I just started Ozempic for weight loss at .25. After my first injection, I was fine for two days, and then was constipated for two days—and since then I’ve been pretty darn sick. Violent diarrhea, headaches, some nausea, and very low energy. I’ve taken several days off from work as I’ve felt so bad. I’ve lost weight since I have no appetite, and nausea follows whenever I eat—even broth and crackers. I have international travel planned in 10 days, and I hope that I’m recovered by then. I may try again after my travels, but this has been rough. The worst side effects I’ve had from a new medication."

• Iri...
• Taken for 1 to 6 months
• October 10, 2019

Semaglutide for Type 2 Diabetes "Started Ozempic a month ago. I had a bit of diarrhea with the first two injections. Now it is just the headache and fatigue feeling. I haven't noticed any changes in appetite. I had been losing weight for three months prior to starting Ozempic. I was down 42 pounds, since starting, I'm up six pounds. I haven't noticed any difference in my blood sugar numbers. Not impressed so far."

• Jan...
• Taken for less than 1 month
• June 22, 2025

For Weight Loss (Obesity/Overweight) "On second week. So far lost 4 lbs, so very happy with that. Not sure if this is the cause, but extremely fatigued. Just want to sleep and do sleep a lot during the day. No more get-up-and-go. Getting nothing done for just don't have it anymore. Going to give it a little more time to see if body adjusts, second injection today. If it doesn't, will have to get off for can't live like this. There isn't a life when all I want to do is sleep."

• ric...
• Taken for 1 to 6 months
• March 25, 2023

Semaglutide for Type 2 Diabetes "I have had terrible side effects from this medication. My legs have swollen to the point of impaired walking, trouble raising either leg to use the shower/tub, and am unable to stand for very long. Shortness of breath, difficulty retaining breath, higher blood pressure, and general fatigue. As for benefits, I really have not noticed any as yet, been too busy coping with the new problems."

• Oze...
• Taken for 1 to 6 months
• September 17, 2022

Semaglutide for Type 2 Diabetes "I started Ozempic in January 2022. First week, I had extreme diarrhea with blood and mucus (always constipated before this). Endocrinologist told me he didn’t think it was Ozempic, but I went off it. Diarrhea, etc., continued. Ended up having to get a colonoscopy and was diagnosed with Ulcerative Colitis. Endocrinologist wanted to put me back on Ozempic. We figured the diarrhea, etc., was just the colitis. Started it back up five weeks ago. No diarrhea, back to constipation, nauseous every day, extreme fatigue. Also now diagnosed with Retinal Vasculitis. But my inflammatory markers are high. Not sure if this all started because of Ozempic. Just increased to 0.5 mg today, so we will see. It just seems like an odd coincidence. No appetite, but no weight loss either. Hair loss, but could be from colitis."

• Cor...
• Taken for 1 to 6 months
• July 29, 2022

Semaglutide for Cardiovascular Risk Reduction "I used this medicine for 3 months to help me lose an excess weight of 30 lbs. I lost 10 lbs. Initially, I had a few side effects: nausea and indigestion. But by the third month, I felt really sick. I asked for blood tests because I was so exhausted. My blood tests were perfect. The indigestion and heartaches got worse. Eventually, it became unbearable. I'm burnt out, so it just made my condition worse. Zombie. For people who support it well, it's great. But if you have a digestive sensitivity, it's at your own risk. I last used the medicine 10 days ago, and I still have digestive problems and heartaches, as well as fatigue. But the fatigue was present before the use of this drug. I lost 10 pounds out of 30 pounds in a month and a half. Then I didn't lose any more, and I continue to be careful. The drug works for 7 days, so it's been 10 days. It is completely eliminated from our body after 5 weeks. It is especially the fatigue that causes me problems. But it's normal when you're still in indigestion."

• Rea...
• Taken for 6 months to 1 year
• August 25, 2021

Semaglutide for Type 2 Diabetes "I've been on Ozempic for about 6 months now, and I've had the absolute worst gastro issues. I didn't notice it much at first, and when I went to my doctor a few months ago, he said it was just my IBS, but after reading these comments, I firmly believe it's the medicine. I have terrible diarrhea. I go at least 8 times a day, and that's no exaggeration. Awful stomach cramps, and I can't even pass gas anymore, literally, I shart. I'm weak and low energy. I've lost 20 lbs, but it's because I'm pooping it away. It helps curb my appetite, and my sugar is good and my A1C is down, but I can't continue this medication. It's truly affected my daily life. I can't go out anywhere that doesn't have a bathroom because when diarrhea hits, I have to go right then. So embarrassing. I'm hoping it's not caused any other issues! Just diet, people, don't take this medicine."

• nau...
• December 30, 2020

Semaglutide for Type 2 Diabetes "I started Ozempic .25 mg subcut 8 days ago. I took my second dose yesterday. My first week, I ended up in the ED. I thought I had a bowel blockage or ileus. The ED visit was preceded by 6 hours of constant, sickening, odiferous belching, constant flatus, eruptive vomiting, cramping, and pain. A CT scan revealed gastric paresis. The event was precipitated by a fatty meal. I have since learned that the decreased gastric motility demands drastic changes in the volume of food intake, fat content, and most importantly, patience with what I consider to be major side effects. Now, I have no appetite. I am nauseated all the time, taking Zofran 4 mg before any meal. The belching is greatly reduced, same with flatus. I feel constipated, but that is easing off. I am avoiding high-fat foods and eating smaller portions. I am profoundly fatigued. Tomorrow, I am getting on the treadmill for 30 minutes each day to stimulate endorphin release to feel better. I have read the symptoms are reduced after 4-6 weeks."

• lee...
• Taken for less than 1 month
• June 15, 2023

Semaglutide for Weight Loss (Obesity/Overweight) "This is my second week on Wegovy. During the first week, I felt fine, but this week, I am experiencing extreme fatigue, tachycardia, headache, and craving sweets. I find myself not eating anything other than meat and no sides. I think I might be done with it. I don't like feeling like this. It's just the second week, and I can't imagine what the third week would feel like."