Semaglutide and Fatigue: What Users Say (Page 3)

• Eve...
• Taken for less than 1 month
• May 21, 2022

Semaglutide for Weight Loss (Obesity/Overweight) "I was recently put on a generic form of Ozempic for weight loss. I’m prediabetic and have tried other forms of weight loss programs that were not sustainable. It’s day 3 now, and although I feel fatigued, my appetite is substantially reduced, and I don’t have nausea anymore. The nausea is actually almost non-existent. I only get it in the morning right after I wake up, and it goes away within minutes. I’m honestly amazed by this medication, but I’m just concerned about the long-term effects of it, such as cancer."

• She...
• Taken for 2 to 5 years
• May 5, 2022

Semaglutide for Cardiovascular Risk Reduction "The medical weight loss program kicked me out because their drugs weren't helping. I lost minimal weight, and the weight I lost was trying to come back on. I had already been eating very moderately for years at this point. I would try to get in some walking, but exercise was limited due to fatigue, pain, and weight. When I went on Ozempic, I experienced a slight increase in fatigue (barely noteworthy), I experienced slight nausea (barely noteworthy), and acid reflux (I took an acid pill on shot day and kept my carbs minimal). Immediately, my feet and hands stopped hurting all the time, and the swelling I wasn't noticing went down, and I realized how swollen I had been. I lost about 20 lbs that stayed off and stable. I eat small amounts, and the reduction in pain made exercising easier, but I have stalled on weight loss. That said, my new weight seems stable. Reduce sugars and carbs, and the acid reflux stays at bay. I've been on it for about 3 years."

• Mom...
• Taken for 1 to 6 months
• December 29, 2021

Semaglutide for Weight Loss (Obesity/Overweight) "Just took my last injection of month 5, 1.7. I have lost about 25-30 lbs along with 3-5 days a week at the gym. Definitely curbs your appetite. The nausea is very real! Each month I thought it would get easier. It never does. A couple times I puked for hours. Lots of belching. In the beginning, a little constipation. The first day or 2 after the injection, you can feel fatigue. It works for weight loss if you can tolerate the nausea. This will be my last month. I have a 6-month prescription but I can’t deal with the nausea anymore."

• SuT...
• Taken for less than 1 month
• August 4, 2021

Semaglutide for Type 2 Diabetes "I have been on Rybelsus for 11 days now. The first few days were horrible. I had diarrhea and stomach pains, even threw up twice. I am still having side effects on day 11 but not as bad. I’m taking Zofran for the nausea. I have already lost 8 lbs, which I’m sure is not healthy, but I don’t have an appetite on this medication. Before this medication, I would eat all the time, it seemed like I never was full. My sugar levels are as low as they’ve ever been. I am tired and have lower energy. I'm hoping after another week on it the side effects will subside. I have been struggling with weight loss my whole adult life and can never break through the plateau phase. I think this medication will help if I can withstand the side effects."

• C01...
• Taken for 1 to 6 months
• July 6, 2021

Semaglutide for Cardiovascular Risk Reduction "3 weeks in... Initially prescribed for weight management. While my appetite's drastically reduced, I've experienced headaches, some brain fog, and felt a little under the weather. Nausea slightly though it reduced day by day. Fatigue's unbearable. I typically have an upbeat, positive attitude and noticed a not-so-good version of myself just recently. Contemplating discontinuing treatment as excited as I am for the weight loss aspect of it :("

• TN ...
• Taken for 1 to 6 months
• October 5, 2020

Semaglutide for Type 2 Diabetes "I've been taking Rybelsus, along with metformin and Farxiga, for over 3 months. I had some minor diarrhea/constipation with the 3 mg that worked itself out quickly, but I lost over 5 lbs and A1C went down over 1 pt (8.3 to 7.2). Just started the 7 mg dose 5 days ago. So far, the diarrhea is a lot worse, and I'm having a lot of dizziness/nausea/fatigue/headaches, but I'm hoping it'll stop soon. I seem to start feeling worse about 5-6 hrs after taking the pill, so I'm sick in bed for hours in the afternoon and evening lately. Not good, as I'm a disabled housewife with two special needs adult children who depend on me. Not sure how someone who works a 9 to 5 job would be able to handle this transition period. If it doesn't sort itself out within a couple of weeks, I'll call my doctor. One tip: keep some saltine crackers and eat a few every hour or so. I know, against diabetic diet, but that and plenty of water help the nausea."

• Art...
• Taken for less than 1 month
• March 14, 2019

Semaglutide for Type 2 Diabetes "I had my first Ozempic 1mg shot on Monday for weight loss. My appetite is well under control. I am experiencing fatigue, especially after eating, requiring me to take a couple of naps a day. I hope my body adjusts to it. I am still able to function and am actually going to the gym every day and eating about 1000 calories per day. My goal is to lose about 35 pounds and then hope to be able to maintain my weight on diet and exercise alone."

• Blu...
• Taken for less than 1 month
• January 2, 2019

Semaglutide for Type 2 Diabetes "I am on my 3rd week of Ozempic. So far, the only noticeable side effects have been fatigue, slight headache after injection, and it has stirred up my GERD a bit. It seems to be working with me. I am hoping all stays as it is now. Probably lucky on the side effects. I delayed taking for 2 weeks to wrestle with the possible side effects."

• Ano...
• Taken for 1 to 6 months
• March 28, 2025

Semaglutide for Type 2 Diabetes "General malaise. Feeling lethargic. Sudden hunger."

• Mic...
• Taken for less than 1 month
• March 15, 2025

For Weight Loss (Obesity/Overweight) "I’m extremely fatigued. Chronic heartburn. Nauseous when eating. Dizzy spells. Back pains. Other than that, I have dropped 25 pounds so far."

• BER...
• Taken for 6 months to 1 year
• August 16, 2024

Semaglutide "In the beginning, I was taking 7 mg, it made me hungry and fatigued. After 6 months, I moved to 14 mg due to weight gain. After taking it for a week, it helped my hunger pangs. I experienced headaches behind my eye and head, fatigued, no energy. I have contacted my doctor for advice. Ease of making it part of your daily routine is easy."

• vtn...
• Taken for 1 to 6 months
• May 29, 2024

Semaglutide for Type 2 Diabetes "One month on Rybelsus. Blood sugar levels are down from 150 to 116-96. I have extreme nausea, constipation, and I am unable to eat more than 1-2 cups of food at a meal. I am rarely hungry. Food seems to become lodged in my esophagus and is painful. I have lost 13 lbs. in a month. Fatigue is an issue. My autoimmune retinopathy, which surfaced after cataract surgery, is worse. I fear I will not be able to continue this med."

• Rox...
• Taken for 1 to 6 months
• May 16, 2024

Semaglutide for Type 2 Diabetes "User, I followed the prescribed regimen of 3mg daily for two months, taking the pill with minimal water between 5 and 8 AM. However, I experienced persistent nausea, burping with a peculiar taste, and a sharp decline in appetite, particularly for sweets. I lost around 10-12 lbs and struggled to drink water, feeling as if my throat was constricted at times. This led to dehydration and widespread body cramps. Trying Gatorade alleviated the issue temporarily, but the discomfort persisted. Upgrading to 7mg exacerbated the symptoms, causing extreme fatigue, body aches, and lightheadedness. I stopped three pills short of completing the 30-day dose to restore my well-being. In total, I've shed 19 lbs."

• Jea...
• Taken for less than 1 month
• June 7, 2023

Semaglutide for Type 2 Diabetes "Nausea, bad acid reflux at night, nightmares, headache every morning, constipation, chills, fatigue. Just started a week ago. Blood sugar levels in the 80s and 90s. Have lost no weight. Zero appetite. Blurry vision."

• Zen...
• Taken for 1 to 6 months
• April 10, 2023

For Weight Loss (Obesity/Overweight) "Super constipated. Super fatigued. Weight loss after 3 months = 8%. Currently at 1 mg dosage level. Had to start taking Linzess to combat constipation. The loss of energy seems severe. I'm happy with weight loss, but hate side effects!!!"

• Zen...
• Taken for 1 to 6 months
• April 10, 2023

For Weight Loss (Obesity/Overweight) "Super constipated. Super fatigued. Weight loss after 3 months = 8%. Currently at 1 mg dosage level. Had to start taking Linzess to combat constipation. The loss of energy seems severe. I'm happy with weight loss, but hate side effects!!!"

• Suz...
• Taken for 1 to 6 months
• June 20, 2022

Semaglutide for Cardiovascular Risk Reduction "I started Ozempic in January 2022. Began with the standard .25 for 4 weeks, then .50 for an additional 4. When I injected the 1 mg, I was sick constantly. Vomiting, fatigue, and horrible heartburn. I had to stop for several weeks as I was completely worn out. I started again with the .25 and am now on the .50, but I'm noticing I am much more hungry than I was the first time around. I was wondering if any of you have injected .75 and if you found it to be helpful? I am afraid to try the 1 mg again as sick as it made me."

• agg...
• June 7, 2021

Semaglutide for Type 2 Diabetes "I started taking this 3 weeks ago. I didn’t really have any terrible side effects other than fatigue, but after my third injection, nausea, diarrhea, and stomach pain hit me with a vengeance. I feel like I ate rotten eggs. I’m not sure I want to continue taking this. I might try injecting it in my thigh like some others have tried. I hope it works because my glucose readings have been in the 90s to 120."

• Sme...
• Taken for less than 1 month
• July 9, 2019

Semaglutide for Type 2 Diabetes "Been on a few weeks at .25. Biggest side effect is sulfur burps, nauseous, and extreme fatigue that start the day after the weekly injection and lasts for a few days."

• Nes...
• Taken for 1 to 6 months
• May 3, 2019

Semaglutide for Type 2 Diabetes "Was diagnosed with type 2 diabetes in March 2019. Doctor put me on Ozempic rather than insulin, although it's not recommended. He thought it was worth a try along with 500 mg metformin twice daily. The first 3 weeks of 0.25 mg Ozempic were just fine. Very minimal side effects - occasional diarrhea, some gas, and belching. Nothing I couldn't handle. The fourth week of 0.25 mg was worse. Constant diarrhea for four days, nausea, some vomiting. I went to a different doctor thinking I had a stomach virus, he prescribed me an anti-diarrheal, and I felt better. I took the Ozempic at 0.5 mg then, as prescribed. Two days later, nightmare. Diarrhea again, vomiting, nausea, and serious fatigue. I'm in the throes of it right now, and I'm going to be contacting my doctor to see what I can do to counteract this. Besides the side effects, though, it's working beautifully. My blood sugar is down from the high 300s to the low 100s in just a month."

• dru...
• Taken for 1 to 6 months
• January 28, 2019

For Type 2 Diabetes "In a drug study for weight loss. I am losing about 1-2 pounds a week consistently for the past 5 months (20 pounds so far). Side effects are worst 1-2 days after the weekly injection. Fatigue, nausea, gas... You have to eat plenty of fiber to not be constipated. I have also experienced vivid dreams off and on since starting the drug. I am torn between tolerating the side effects and losing the weight. I will try to stay in the study until I have reached an acceptable weight for my size and age. I would highly suggest it for the obese. Good luck!"

• jud...
• Taken for 1 to 6 months
• March 15, 2025

Semaglutide for Cardiovascular Risk Reduction "2-3 days per week I suffer from poor sleep and fatigue accordingly. Trying to get to sleep is bad, with body noises making it impossible. Also, constant burping with gas buildup, farting at night is awful, watery eyes. The other 4 days is fine. The days are not in a row and often vary each week. My rating of the medicine would vary on different days, bad days, bad rating."

• udg...
• Taken for 1 to 6 months
• February 14, 2025

Semaglutide for Type 2 Diabetes "Terrible nausea and violent diarrhea. Fatigue. Minor weight loss. Blood sugars stabilized."

• Anonymous
• Taken for 1 to 6 months
• November 13, 2024

Semaglutide for Type 2 Diabetes "I’ve experienced loss of appetite. In less than 6 months, I’ve lost 9 lbs., hair loss, fatigue, lack of sleep, cannot stand some food. I start eating, cannot finish; revulsion."

• mew...
• Taken for 1 to 6 months
• August 27, 2024

Semaglutide for Type 2 Diabetes "I’m 63 F with T2 diabetes, and I started on Oz mid-May 2024. Symptoms: nausea, fatigue, GERD, sulfur burps, stomach cramping from severe constipation, constipation, feeling like I need to vomit, ringing in my ears has increased significantly, loss of appetite, reduction of inflammation, occasional migraines, feeling “off” most days, bouts of dizziness, and feeling faint, but blood sugar and blood pressure are normal, improved blood sugar readings, weight loss of 13 lbs. There are some perks: rheumatoid and osteoarthritis inflammation has lessened, though I still feel pain daily, it’s more tolerable. I take no painkillers but will take CBD as needed. Loss of appetite has led to a loss of 13 lbs so far, blood sugar improved so I’m confident that my A1C has improved also. I struggle with what to do: stay on for the inflammatory reductions, weight loss, and blood sugar improvement benefits, or quit because I feel sick most days, so I have no real pleasure in life anymore. No, I’m not depressed."