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Seroquel XR User Reviews & Ratings

Seroquel XR has an average rating of 7.1 out of 10 from a total of 205 reviews on Drugs.com. 62% of reviewers reported a positive experience, while 19% reported a negative experience.

Reviews for Seroquel XR

  • josia...
  • May 25, 2021

For Depression "I am diagnosed with BPD, severe anxiety, and depression. I've tried multiple antidepressants before, and none of them worked for me. My doctor prescribed me 50 mg of Seroquel XR, and I take it before going to sleep. I have now been taking it for 3 months, and it literally saved my life. I've experienced some side effects at first, but now that my body is used to the medication, I feel so much better. I can go out, see friends, and do a lot of things I couldn't even think about doing 2 months ago. In contrast to a lot of people, I didn't gain weight yet; I even lost some. It also helps my mood swings and my dissociation. The only negative thing I can think of is the tiredness. But, if I get out of bed right away, I'm good for the day. I can recommend not to take it too late because it can make it hard to wake up in the morning. In conclusion, I think it's a great medication, and even if you're scared to take it, just give it a try and let it time to start working."

10 / 10
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  • sarra...
  • Taken for less than 1 month
  • June 14, 2014

For Depression "I have only been on Seroquel 25 mg for just over a week. So I cannot say if I will experience the weight gain or not. But so far, this is the best thing that's worked for me. I was horrifically depressed and anxious for over a year, and before that moderately. But after just 1 day on the Seroquel, I felt a huge difference. My thoughts had slowed down, my anxiety and depression got cut in half, my appreciation of time and continuity came back a bit, and the disassociation was appeased. For the past year, I felt like I was on one giant bad paranoia trip, and only after I started taking this medicine did I start feeling normal again. There are still major things that are a problem, but the Seroquel makes it way more manageable."

9 / 10
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244 Report
  • cdfig
  • February 20, 2015

For Depression "Seroquel XR worked very well for me with a combination of Seroquel and Zoloft together. I've been well for over 3 years now. Usually I would fall into a depression within a year just taking an antidepressant because my body would build a tolerance to the medications. I know this medicine isn't for everyone, but I've had a very good experience and I'm stable and happy."

10 / 10
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148 Report

Frequently asked questions

  • Wanna...
  • February 7, 2014

For Depression "I am presently in the hospital and have been put on Seroquel XR. As previously commented, the low dosages cause lethargy and sleepiness. However, I am not nearly as suicidal as I was, I have hope for the future and have not been on it for more than a few days. I am optimistic that once I have reached the proper dosage, I will once again enjoy life as I once did. Paxil, Effexor, and a number of other antidepressants worsened my symptoms over time and/or never did much for the depressive symptoms in the first place. This medicine is worth trying if you are extremely depressed or suicidal."

10 / 10
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156 Report
  • TOC...
  • Taken for 1 to 6 months
  • May 30, 2013

For Depression "After taking Seroquel for 5 months at 25 mg, I recently upped it to 50 mg at night-time. This has resulted in me being able to drop my Ativan from 2 mg to 1 mg and still get a great sleep. I am much more productive, think clearly, and feel positive. I feel like my personality is coming back. Coincidence? I think not."

8 / 10
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162 Report

Are you taking this medicine?

  • Anonymous
  • February 2, 2012

For Depression "I've had depression since I was a young teenager. I didn't decide to get treatment until I was 24. I felt like I was unraveling. I didn't want to get out of bed. I lost interest in all the things that I once loved to do. I had problems with drugs and alcohol. Sleeping problems. The whole nine yards. The medication that my doctor decided to put me on was Seroquel XR. I was a little apprehensive at first, being a drug user for many years, I knew what Seroquel was. My doctor assured me that in a controlled and carefully watched environment, she believed it would help. She started me on 50 mgs. I've moved to 150 mgs. I've had drastic positive changes in my mood. I feel happy, rested, and content. No negative side effects. It worked miracles."

10 / 10
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172 Report
  • Anonymous
  • May 26, 2011

For Depression "Seroquel XR has changed my life. I feel I am present again in my world. Before taking this medication, I had very little hope that I would ever feel enthusiastic about life. I recognize myself again. I can't say enough about how excited I am about living. I tried so many therapies and had given up hope anything would work. The combination of my antidepressant and Seroquel XR was the key for me."

10 / 10
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152 Report
  • Anonymous
  • Taken for 6 months to 1 year
  • June 6, 2013

For Depression "I have had depression since I was a child, but I didn't start getting help for it until I was 19. I have tried Prozac and Celexa, which did nothing for me, and then my doctor asked me if I have ever heard of a medicine called Seroquel XR. I started out on 50mg and then worked my way up to 300mg. The only side effects for me were weight gain and drowsiness, but the drowsiness went away after a couple of months of using this medicine. Overall, I really like this medicine. It has helped me tremendously!"

10 / 10
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128 Report
  • Anonymous
  • June 2, 2011

For Depression "Read a lot of bad things about Seroquel on the web. After a couple of days, I tried it myself (100 mg a night) and I've found it amazing. It really helps with my anxiety and my hyperactive behavior. I just feel a lot more calm and settled in general. Don't believe everything you read. Just try it for a few nights and see how it suits you. Everyone is different."

10 / 10
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144 Report
  • shell...
  • November 14, 2013

For Depression "I have used this for years now! I love it, before taking I absolutely could not sleep. I started out with 50mg, and am now taking 75mg after all of these years. I cannot sleep without it and I have no side effects from this medicine."

10 / 10
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123 Report
  • Anonymous
  • Taken for 1 to 6 months
  • January 5, 2014

For Depression "Made me a zombie at low doses and didn't help with depression. In fact, I felt even more depressed since I wasn't able to hold a conversation or think straight due to drowsiness. But it seems to work for some people."

1 / 10
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105 Report
  • robbi...
  • Taken for 5 to 10 years
  • December 24, 2015

For Depression "I've been on Venlafaxine 300mg along with Quetiapine, Mirtazapine, and Pregabalin for Major Depression for around 7 years. Augmentation therapy works for me. It's not perfect, but this level of Venlafaxine along with the other meds has kept me alive. I'm not getting better, but I'm certainly more stable and not going downhill and not suicidal. So in conclusion, don't be scared of meds, they may just save your life."

9 / 10
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88 Report
  • Kmtdstr
  • Taken for 2 to 5 years
  • October 2, 2015

For Depression "I have taken it for PTSD at night for a long time. I'm able to sleep without having horrific nightmares. There is weight gain, but that boosts me to eat healthy and exercise, which helps my depression! Klonopin to help with daytime anxiety and Seroquel before bed are the two drugs that keep me sane and able to live a normal life."

10 / 10
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81 Report
  • Happy...
  • October 19, 2010

For Generalized Anxiety Disorder "I was on Seroquel for two years and loved it except at the beginning I was very sleepy, but it went away after a few weeks. I was very shaky, but other than that, it was wonderful. I am drug-free and loving it today; easy to go off it too."

10 / 10
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112 Report
  • Srzta...
  • Taken for 5 to 10 years
  • July 12, 2015

For Bipolar Disorder "This medication completely changed my life. My diagnosis is mixed rapid-cycling bipolar disorder with psychotic features. Before my regimen, I would suffer a week of depression, followed by a day of dangerous mixed affective episode, followed by a few hours of euphoria before the process would begin all over again. I had ruminating and intrusive thoughts, panic attacks, anxiety, extreme guilt, dissociation, and suicidal ideation (and a few near-attempts). But, within weeks of the therapeutic dose, my mood stabilized; my anxiety dropped off; my obsessive and intrusive ruminations relinquished their hold, and unexpectedly, I gained a spectrum of emotions I didn't even know I lacked (and that was the best thing of all). Truly life-altering."

10 / 10
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  • mik
  • Taken for 6 months to 1 year
  • June 17, 2018

For Depression "After being hospitalized twice for suicidal ideation, my psychiatrist decided to put me on Effexor and 150mg of seroquel. I was in the hospital while I started the medication, but at the beginning all I could do was sleep for a few days or so. I wasn’t affected by that too much because I was inpatient, but I read some others mentioning this and I can imagine it would definitely get in the way of trying to go about your everyday. Also my mouth was so dry and I lost my appetite (among other symptoms that I don’t really remember). Those symptoms, while very debilitating, subsided within a few weeks though and now I’m much better and I honestly rarely if ever feel depressed any more! I was very reluctant to go on medication but it’s kept me alive so I guess I can’t really hate it that much. This drug, while causing a lot of problems in the beginning, turned out to be a life saver (literally)."

8 / 10
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59 Report
  • Sympt...
  • January 31, 2011

For Depression "I recently started Seroquel 50 mg for the first couple of days and then up to 150 mg. This medication works great! It creates anxiolytic effects similar to Klonopin and relieves all my anxiety. I sleep well too. This medicine really knocks you out and makes you very sedated. Take it at night. I can actually function thanks to this medication and it works excellently for paranoia, anxiety, and depression. I also found it to work greatly for sleep. I was previously on Abilify, which was very activating and gave me a lot of anxiety. I couldn't sleep more than 1-2 hours with Abilify. On Seroquel, I sleep a full 8 hours, and I wake up refreshed and ready for the day. It controls my anxiety and works wonders. Side effects are: No sex drive and drowsiness."

8 / 10
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100 Report
  • Sofie
  • Taken for 10 years or more
  • September 4, 2019

For Bipolar Disorder "I have Bipolar Disorder Type 2. I'm on Seroquel XR 150mg for 10 years now. Before I was on Seroquel 300mg for more than a year. I have tried different antipsychotic medicines combination for years but only Seroquel works for me. Changed my life for the better. I have chronic insomnia, tried all sleeping pills but only lasted for weeks then I couldn't sleep anymore. But Seroquel put me to sleep, deeper sleep and wake up feeling better. I just need to sleep every night on the same time. Also I gained weight, and the side effect when I feel groggy at night I feel hungry so I ended up eating at midnight. I know it sucks that I gained weight. Tried to stop taking it for few days then my depression attack me very sudden and my mood fluctuations. From then I never stop taking Seroquel and I feel better. I told to my psychiatrist that Seroquel is my best friend, without it I feel horrible. It is indeed a lifesaver."

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  • KassR
  • July 28, 2008

For Depression "Every day, I was very depressed or very angry for no apparent reason. It felt like my brain was all tangled, and it was really hurting me, and had been for years. So I talked with my doctor, and she put me on 200mg Seroquel. Since then, I can think clearly and feel happy. I love it. You start at 25mg and work up to higher doses. Watch out, though, if you try to start at 200mg, it can knock you out for 24 hours, or at least it knocked me out."

10 / 10
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112 Report
  • Beltane
  • Taken for 2 to 5 years
  • May 27, 2017

For Bipolar Disorder "This drug is a wonder drug. After 15 years of brutal bipolar symptoms (undiagnosed/ untreated) which destroyed my whole life, I now take 300mg at night and now I can have a normal life free of anxiety, mood swings, bipolar symptoms etc, I hold down a responsible full-time job, healthy relationships and friendships, I have hobbies. I never had any of that before; my bipolar destroyed my whole life. Seroquel gave it back. I hear of people wanting to go off Seroquel.. I'm the opposite. I would go to any lengths to make sure I never have to go off it. I'll gladly spend the rest of my life on it, because it gives me a normal life, and I won't risk that for anything. I've been on it 3 years, no side effects."

10 / 10
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60 Report
  • Issy
  • November 10, 2015

For Depression "I was diagnosed with bipolar disorder 8 months ago (i am 19) but I do not have that. Instead I have BPD and depression. I was taking olanzapine which took away my entire life - I could barely do anything, but for the past 2 days with seroquel it has almost the opposite effect. Together with Prozac I have felt more motivated and less suicidal. Also I'm able to control my anxiety and I have more control over my behaviour. I also have trouble focusing but this has helped me focus on therapy a lot more. Sleep not great but I'm only on 25mg ; I only sleep for about 6-7 hours and then wake up and keep going back to sleep. This is the first drug that's given me hope."

9 / 10
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69 Report
  • Mikfr
  • November 28, 2014

For Depression "I was prescribed seroquel 100mg for Post Traumatic Stress Disorder and I could only take it for two days. I took it as prescribed before bedtime. I almost crashed my truck several times on my way to work and I had to pull over on the shoulder to sleep on my way home from work. Day 2 was a Saturday. I slept for 14.5 hours. I can't function at all on this."

6 / 10
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71 Report
  • Kooshs...
  • Taken for 6 months to 1 year
  • November 20, 2013

For Depression "I have had Bipolar Disorder/Personality Disorder and severe depression for about 30 years and have tried just about every medicine there is. A recent set-back had me in hospital: my Dr. decided to put me on Seroquel XR 400 mg along with my other medicines. In the beginning it seemed to help me, as time went on my symptoms of low mood suicidal thoughts, etc. came back...most important to note was the WEIGHT GAIN. In under a year almost 50 lbs for no real reason. Extreme fatigue and sleepiness-hard to get out of bed in the mornings! Am now reducing dosage to slowly get off it as per Dr.'s orders and switching to an alternative. I am hoping this will work."

6 / 10
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76 Report
  • Smittyz
  • August 18, 2008

For Depression "For years I suffered from severe depression. Doctors must have tried every different medicine of this nature in hopes to help me; however, it wasn't until I was given Seroquel that I began to feel better and sleep like a baby. At first, I would sleep 12 to 14 hours after taking the medicine, then I began to get used to it. I haven't had a bout of depression in 3 years. I can sleep again, but now around 8 hours a night. I can honestly say I love this pill. Even with the side effects of hunger, it's totally worth it."

10 / 10
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99 Report
  • Anonymous
  • Taken for 1 to 6 months
  • December 3, 2013

For Bipolar Disorder "Works like a charm. It was prescribed for me for Bipolar I disorder (as part of my cocktail of meds), especially for symptoms involving lack of sleep. I have been struggling with sleep problems for so many years, and this works great for me at 50 mg. It even helps with depression and anxiety temporarily. I feel a lot calmer, which is definitely needed for me, especially at night. It helps with racing thoughts and voices as well. No more "noise" in my head at night for most part."

10 / 10
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73 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.