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Seroquel XR User Reviews & Ratings (Page 4)

Seroquel XR has an average rating of 7.1 out of 10 from a total of 228 reviews on Drugs.com. 62% of reviewers reported a positive experience, while 19% reported a negative experience.

Reviews for Seroquel XR

Commonly mentioned side effects
  • mom...
  • Taken for 1 to 6 months
  • October 19, 2012

For Bipolar Disorder "I have had a negative experience on Seroquel. I do not want this to deter anyone from taking it, as everyone's reaction and experience on this medicine is subjective; I just want to put this out there for anyone who might be experiencing similar symptoms and reactions and may be hesitant to say it and to just relate my own experience. I am bipolar II and have untreated ADHD due to the ADHD medicines causing manic episodes. I started Seroquel 2 months ago when I was having a bout of insomnia. I should state that I was on Wellbutrin, Lamictal, and Paxil, and was feeling good. I was productive during the day and upbeat. I was prescribed Seroquel for the insomnia and taken off all the others except Lamictal. I am now a 'zombie', depressed, sleepy 24/7."

1 / 10
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  • Suz...
  • Taken for less than 1 month
  • June 26, 2012

For Insomnia "My Dr. gave me a sample of this medicine to try, and it works well, however, it takes me a while to fall asleep, and it gave me a hangover effect the next day! I liked the sleep it gave me, but I had a hard time waking up the next day."

6 / 10
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  • Dai...
  • April 6, 2015

For Bipolar Disorder "At first, I hated this medication. It made me really tired, with feelings of non-reality and weight gain. The doctor who put me on it said to wait and give it a chance. I'm glad I did. I use it to sleep at night. At some point, I will reduce it, but it's great for now. I have very restful sleeps, but I am unable to remember my dreams. I am bipolar, and although I am on other medication for it, I believe that Seroquel has been key in my mood stability. I take 100 mg every night and 25 mg PRN for anxiety if needed. Although I get tired on it, it does slow down my thoughts."

8 / 10
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29 Report

Frequently asked questions

  • Dan...
  • Taken for 6 months to 1 year
  • July 17, 2021

For Depression "I have been on the Seroquel XR 50 mgs, and it absolutely works better than anything I have ever taken for anxiety. And I've taken every SSRI under the sun, Valium, clonidine, gabapentin, and Vistaril all in the past. This medication is a lifesaver. It does make me feel drowsy 3-4 hours after taking it, so it should be taken around dinner time. My doc first started me on it first thing in the morning, and I was dozing off by noon. But other than that, it has been a lifesaver. Almost no anxiety, I sleep better, my appetite is good, my mood is good and confident. For me, it even helps to relax my muscles. I'm so glad my doc took a chance and prescribed this medication off-label for my anxiety. It has given me a new lease on life."

10 / 10
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  • Eli...
  • November 28, 2014

For Major Depressive Disorder "Seroquel for depression isn't heard of much. I'm on it, and yes, at first, it was horrible. Head spins and just like motion sickness. But I was advised to stick it out and did. Approx. 6 weeks it settled down. I take it for bipolar, the racing mind, no sleep, or little sleep. With Seroquel, I sleep a night's rest. My mind isn't active at all. I'm on 300 mg. A bit tired of a morning, but if you are up early, which can be hard, the effects wear off sooner. I won't swap to any other, I tried Zyprexa, but I'm sticking with Seroquel."

9 / 10
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  • van...
  • Taken for 1 to 6 months
  • September 13, 2016

For Bipolar Disorder "Have been on Seroquel XR 25 mg (once before bed) for about 6 months now, and my life has completely changed for the better. Yeah, the weight gain is a pain, but it's a small price to pay for normality. Social anxiety/severe insomnia has not been an issue for months!! I'm finally myself again. Have tried other antipsychotics, but nothing works as well as this one. Only downside is an insatiable appetite - but you can minimize weight gain by substituting with fruits, etc., which is what I'm currently doing."

8 / 10
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  • txf...
  • March 9, 2010

For Bipolar Disorder "Seroquel XR has been a blessing for me. I currently take 600 mg at night. I have suffered from terrible insomnia, but with this medicine, I actually get some sleep at night. As far as anxiety goes, it works wonders for me. It totally wiped out my anxiety, and I was able to get off of Lithium. In my opinion, it works wonderfully for mania, but I wish it helped a little more with my depression. I take 10 mg of Prozac to boost that. I did gain some weight, but the benefits outweigh this problem. Overall, I think it is a wonderful medicine. I would recommend it highly."

9 / 10
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  • Cye...
  • Taken for 2 to 5 years
  • April 8, 2015

For Bipolar Disorder "For years I took Seroquel in various doses throughout the given day. I was prescribed Seroquel XR about 3 years ago for anxiety and bipolar I. Since then, it has been very effective. I did not gain weight at all. The only drawback is it does cause dizziness and sleepiness. Therefore, I sometimes opt to take it later than prescribed, 7:30 pm instead of 6."

10 / 10
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  • Anonymous
  • April 10, 2009

For Depression "I was put on this medicine very aggressively (200 mg, quickly upped to 400 mg) after a suicide attempt. As an antidepressant, it is more effective than the first-line medications like citalopram. It will help with sleep and a lack of hunger. However, I absolutely hate the side effects. It is often said that antipsychotics 'steal your soul' or act like a 'mental prison.' I would have to agree. To begin with, this was fine, with severe depression, I was happy to take any way out. However, after about 6 months of this, I decided enough was enough. Now I'm off it, my personality is back."

6 / 10
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  • The...
  • March 15, 2014

For Bipolar Disorder "Aching or discomfort in the lower legs, or sensation of crawling in the legs, unusual tiredness or weakness, dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position, muscle pain or cramps."

7 / 10
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  • Anonymous
  • August 25, 2011

For Bipolar Disorder "I used to be so paranoid I couldn't even sleep at night. I would go into manic episodes and be in la-la land for days until this wonderful pill came into my life. I have never felt better. I just never felt so good, I'm happy."

10 / 10
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  • Obs...
  • October 22, 2009

For Obsessive Compulsive Disorder "Diagnosed with GAD and OCD, more so the mental aspect (the obsessions). On clonazepam, Zoloft 200 mg, and Seroquel XR 50 mg a few hours before bed. I have to say that it feels great and helps me fall asleep, but I still have some anxiety-driven dreams. The hours before sleep are wonderful, it really takes you down a level or two. I just wish it lasted 24 hours."

7 / 10
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  • sho...
  • April 9, 2016

For Bipolar Disorder "I was prescribed Seroquel XR for bipolar depression. My doctor started me on 50 mg, and I am gradually increasing the dosage. It's been about 4 weeks, and I am currently taking 200 mg. I will agree that it has helped the hopelessness feelings and suicidal thoughts, which is a plus, but the zombie-like feeling and dry mouth are tough. I have a job that requires constant activity, it's hard to keep up. I have to definitely slow down. My doctor advised me that these side effects are all normal and eventually I will get used to it. Can't wait for this to happen."

7 / 10
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  • Bue...
  • November 7, 2011

For Depression "The first night I took this medication, I almost ran out of breath before climbing the stairs from the basement to my room (it's as if my respiratory system was somewhat repressed). It also caused some chest/heart pain. On the other hand, I slept well for those two nights. The side effects may be more dangerous than one's condition. Please be careful."

5 / 10
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  • Gas...
  • Taken for 2 to 5 years
  • May 20, 2017

For Depression "I was on this medication for around 3 years at different doses, anywhere from 50 mg to 600 mg. It was a very good medicine and helped a lot with my anxiety and depression and really calmed me down and was very helpful, but the weight gain was a killer. I would try to go off over and over and would have to keep going back to it because I would be in such bad shape without it. I had a love/hate relationship with it. I became pre-diabetic while on it. I finally was able to go off and stay off at one point. It's a great drug, but the side effects are horrible as far as weight gain."

8 / 10
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  • Mia...
  • Taken for 1 to 6 months
  • September 29, 2018

For Depression "I got prescribed Seroquel XR for my sleep, and it is supposed to help me with my sleeping, and it does. I don’t follow a specific roster of when I’m meant to take it, so I’m on and off every week, and I only just started noticing that when I start taking it after a while of not taking it, my depression gets worse. I’m not really sure of what’s going on."

3 / 10
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  • Bef...
  • February 7, 2019

For Bipolar Disorder "I've taken this medication in the past. I required a higher dosage because I was feeling paranoid. A few months ago, I weaned myself off of it, but I took other medications. I started to lose weight, and I was feeling healthy physically, but mentally my mind was active. I don't feel paranoia like I did in the past, but lately I'm taking a low dose of 150 mg compared to 600 mg several months ago. If I take it too soon before bedtime, I tend to feel groggy in the morning, and it takes me 9 hours of sleep. It can cause weight gain and diabetes. Make sure you have your blood sugar monitored every 3 months. Eat small snacks, fewer carbs, and exercise. Healthy sleep makes you happy."

8 / 10
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  • Sle...
  • March 9, 2012

For Insomnia "Seroquel was the only thing that knocked me out. I've been on it for 8 months, but have gained 50 lbs, which I have attributed to Seroquel. Not to mention that diet and exercise aren't cutting it to lose the weight. Wish I could find something that could make me sleep as well as Seroquel without the weight gain."

6 / 10
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  • Ano...
  • June 6, 2016

For Bipolar Disorder "I really noticed a negative difference when comparing the XR version to the regular Seroquel. It took longer to kick in and made me so drowsy at work that I felt like I was drunk. I think I was taking 100-200 mg. When I went back to regular Seroquel, 100-200 mg put me to sleep fast and made a difference in stabilizing my mood without me feeling too drowsy to function the next day."

4 / 10
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  • Anonymous
  • September 18, 2011

For Depression "Seroquel XR is very good. It boosts up my energy. After trying other medications, this is the best, with little side effects. In the morning, you feel like staying in bed and weight gain because of hunger cravings."

9 / 10
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  • Pat...
  • Taken for 1 to 6 months
  • April 29, 2017

For Bipolar Disorder "I don't understand all the negative reviews. For me, this pill has worked well. It's calmed me right down and has been blissful at moments. It's expensive, unfortunately. As for weight gain, I've noticed that it's pretty neutral... Granted, I'm weaning off of Zoloft as well, so who knows, but I find with medications with 'weight gain' as a side effect, just trying your hardest to eat a well-balanced diet will prevent it. It's too easy to give up and say, 'Oh well, I'm gonna get fat'-it's very much not the case. Don't give up. If you're bipolar like me, there's a chance you can do a lot with your brain, so give it a shot and take your life back. I think much more clearly and am more productive. The overwhelming tiredness subsided after one week."

9 / 10
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  • KRC...
  • January 8, 2012

For Generalized Anxiety Disorder "I loved how the XR worked for me. I was on 50 mg at night. It was a 30-day trial to see if it would help me, it did. My GP gave me the XR, then my psychiatrist switched me to the IR 25 mg so I could take either 1 or 2 pills depending on how I felt. That seemed to be working okay, but I had another anxiety attack, and it has been 5 days since, and I am still not recovered. Tonight, I am going to take the XR and see what tomorrow brings. Luckily, I do go to my Dr. as well. I am sure that I will feel better tomorrow, as I felt great the day after my first XR dose."

9 / 10
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  • KoR...
  • February 3, 2011

For Bipolar Disorder "I had a 'nervous breakdown' in November of 2009 and ended up in a psych hospital where I was promptly given Seroquel, among other medicines. The Seroquel was amazing. I felt like someone switched the on button in my brain and I finally woke up. When I got out of the hospital and sought out a new psychiatrist for treatment, he took me off of the Seroquel because I am diabetic. After a year of unsuccessful treatment with other medicines, I begged to be put back on the Seroquel because the depression was unbearable, and I wasn't responding to other medicines. So he agreed, and once again that switch has been flipped on and I feel 'normal'! I am only on 300mg. I have to take it early because it knocks me out. In the morning, I am very dizzy and have slurred speech."

10 / 10
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  • Lon...
  • Taken for 6 months to 1 year
  • November 18, 2017

For Bipolar Disorder "I was taking 300 mg of Seroquel XR for 6 months. The best part was being able to get a good night’s sleep. I had only been getting 2-3 hrs of rest each night. My mind would race and it was a struggle to stay in bed. I would get up and start cleaning. Additionally, I would spend hours creating plans to organize my life. I had not actually followed any of those plans, and I was depressed. I took Latuda for a short period, but it made my inability to sleep worse. That’s when I was switched to Seroquel. I loved the way it helped me feel normal. The bad - I gained 30 lbs in 6 months. I asked to be taken off and started taking Geodon. Once again, I cannot sleep. I am going to ask to go back to Seroquel XR and focus on following a healthy diet."

9 / 10
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  • bab...
  • June 29, 2009

For Bipolar Disorder "I think this is one of the best medications out there at this time. It has really changed me 100%. I have bipolar, and I can't tell you how happy I am. I have also been on regular Seroquel, and there is no comparison, XR for me works far better than the regular."

10 / 10
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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.