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Medications for Major Depressive Disorder

The medications listed below are related to or used in the treatment of this condition.

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Drug name Rating Reviews Activity ? Rx/OTC Pregnancy CSA Alcohol
Paxil CR 10 3 reviews for Paxil CR to treat Major Depressive Disorder
Rx D N X
Generic name:
paroxetine systemic
Drug class:
selective serotonin reuptake inhibitors
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
nefazodone 9.0 30 reviews for nefazodone to treat Major Depressive Disorder
Rx C N X
Generic name:
nefazodone systemic
Drug class:
phenylpiperazine antidepressants
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Auvelity 8.3 89 reviews for Auvelity to treat Major Depressive Disorder
Rx N X
Generic name:
bupropion / dextromethorphan systemic
Drug class:
miscellaneous antidepressants
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
bupropion / dextromethorphan 8.3 90 reviews for bupropion / dextromethorphan to treat Major Depressive Disorder
Rx N X
Generic name:
bupropion / dextromethorphan systemic
Brand name:
Auvelity
Drug class:
miscellaneous antidepressants
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph
Aplenzin 8.2 5 reviews for Aplenzin to treat Major Depressive Disorder
Rx C N X
Generic name:
bupropion systemic
Drug class:
miscellaneous antidepressants
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Wellbutrin SR 8.1 24 reviews for Wellbutrin SR to treat Major Depressive Disorder
Rx C N X
Generic name:
bupropion systemic
Drug class:
miscellaneous antidepressants
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Budeprion SR 8.0 2 reviews for Budeprion SR to treat Major Depressive Disorder
Rx C N X
Generic name:
bupropion systemic
Drug class:
miscellaneous antidepressants
For consumers:
dosage, interactions, side effects
Zyprexa Zydis 8.0 2 reviews for Zyprexa Zydis to treat Major Depressive Disorder
Rx C N X
Generic name:
olanzapine systemic
Drug class:
atypical antipsychotics
For consumers:
dosage, interactions, side effects
fluoxetine / olanzapine 7.8 12 reviews for fluoxetine / olanzapine to treat Major Depressive Disorder
Rx C N X
Generic name:
fluoxetine / olanzapine systemic
Brand name:
Symbyax
Drug class:
psychotherapeutic combinations
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Remeron 7.6 65 reviews for Remeron to treat Major Depressive Disorder
Rx C N X
Generic name:
mirtazapine systemic
Drug class:
tetracyclic antidepressants
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Wellbutrin XL 7.4 126 reviews for Wellbutrin XL to treat Major Depressive Disorder
Rx C N X
Generic name:
bupropion systemic
Drug class:
miscellaneous antidepressants
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
doxepin 7.3 5 reviews for doxepin to treat Major Depressive Disorder
Rx N N X
Generic name:
doxepin systemic
Drug class:
miscellaneous anxiolytics, sedatives and hypnotics, tricyclic antidepressants
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
paroxetine 7.3 56 reviews for paroxetine to treat Major Depressive Disorder
Rx D N X
Generic name:
paroxetine systemic
Brand names:
Paxil, Paxil CR
Drug class:
selective serotonin reuptake inhibitors
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
mirtazapine 7.1 190 reviews for mirtazapine to treat Major Depressive Disorder
Rx C N X
Generic name:
mirtazapine systemic
Brand names:
Remeron, Remeron SolTab
Drug class:
tetracyclic antidepressants
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Paxil 7.1 36 reviews for Paxil to treat Major Depressive Disorder
Rx D N X
Generic name:
paroxetine systemic
Drug class:
selective serotonin reuptake inhibitors
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Remeron SolTab 7.0 1 review for Remeron SolTab to treat Major Depressive Disorder
Rx C N X
Generic name:
mirtazapine systemic
Drug class:
tetracyclic antidepressants
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Spravato 7.0 51 reviews for Spravato to treat Major Depressive Disorder
Rx 3 X
Generic name:
esketamine systemic
Drug class:
miscellaneous antidepressants
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Symbyax 7.0 8 reviews for Symbyax to treat Major Depressive Disorder
Rx C N X
Generic name:
fluoxetine / olanzapine systemic
Drug class:
psychotherapeutic combinations
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
bupropion 6.9 422 reviews for bupropion to treat Major Depressive Disorder
Rx C N X
Generic name:
bupropion systemic
Brand names:
Wellbutrin XL, Wellbutrin SR, Aplenzin, Budeprion SR, Forfivo XL
Drug class:
miscellaneous antidepressants, smoking cessation agents
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
esketamine 6.9 53 reviews for esketamine to treat Major Depressive Disorder
Rx 3 X
Generic name:
esketamine systemic
Brand name:
Spravato
Drug class:
miscellaneous antidepressants
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph
Emsam 6.7 15 reviews for Emsam to treat Major Depressive Disorder
Rx C N X
Generic name:
selegiline systemic
Drug class:
monoamine oxidase inhibitors, dopaminergic antiparkinsonism agents
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
sertraline 6.7 229 reviews for sertraline to treat Major Depressive Disorder
Rx C N X
Generic name:
sertraline systemic
Brand name:
Zoloft
Drug class:
selective serotonin reuptake inhibitors
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Zoloft 6.7 144 reviews for Zoloft to treat Major Depressive Disorder
Rx C N X
Generic name:
sertraline systemic
Drug class:
selective serotonin reuptake inhibitors
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Effexor XR 6.6 114 reviews for Effexor XR to treat Major Depressive Disorder
Rx C N X
Generic name:
venlafaxine systemic
Drug class:
serotonin-norepinephrine reuptake inhibitors
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
fluoxetine 6.6 139 reviews for fluoxetine to treat Major Depressive Disorder
Rx C N X
Generic name:
fluoxetine systemic
Brand name:
Prozac
Drug class:
selective serotonin reuptake inhibitors
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information

Frequently asked questions

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Learn more about Major Depressive Disorder

Care guides

Legend

Rating For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective).
Activity Activity is based on recent site visitor activity relative to other medications in the list.
Rx Prescription only.
OTC Over-the-counter.
Rx/OTC Prescription or Over-the-counter.
Off-label This medication may not be approved by the FDA for the treatment of this condition.
EUA An Emergency Use Authorization (EUA) allows the FDA to authorize unapproved medical products or unapproved uses of approved medical products to be used in a declared public health emergency when there are no adequate, approved, and available alternatives.
Expanded Access Expanded Access is a potential pathway for a patient with a serious or immediately life-threatening disease or condition to gain access to an investigational medical product (drug, biologic, or medical device) for treatment outside of clinical trials when no comparable or satisfactory alternative therapy options are available.
Pregnancy Category
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act (CSA) Schedule
M The drug has multiple schedules. The schedule may depend on the exact dosage form or strength of the medication.
U CSA Schedule is unknown.
N Is not subject to the Controlled Substances Act.
1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
Alcohol
X Interacts with Alcohol.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.