Comparing Trazodone vs Zaleplon

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Trazodone	Zaleplon	Enter another drug to compare

Trazodone

Zaleplon

Prescription only

Trazodone is mostly used for its sleep-inducing effects (an off-label indication) rather than as an antidepressant. Only generic forms are available which makes it a lot cheaper than some other... View more

Prescription only

Prescribed for Insomnia. Zaleplon may also be used for purposes not listed in this medication guide.

More about Trazodone

More about Zaleplon

Ratings & Reviews

Trazodone has an average rating of 6.3 out of 10 from a total of 1433 ratings on Drugs.com. 53% of reviewers reported a positive effect, while 31% reported a negative effect.

Zaleplon has an average rating of 5.3 out of 10 from a total of 134 ratings on Drugs.com. 43% of reviewers reported a positive effect, while 43% reported a negative effect.

View all 1433 reviews

View all 134 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Drowsiness (17.7%)
Headaches (9.6%)
Dizziness (8.7%)
Anxiety (5.9%)
Dry mouth (5.7%)
Tiredness (4.9%)
Insomnia (4.6%)

View all Trazodone side effects

Drowsiness (7.5%)
Hangover (6.0%)
Insomnia (5.2%)
Anxiety (4.5%)
Hallucinations (3.7%)
Headaches (3.0%)
Tiredness (3.0%)

View all Zaleplon side effects

Drug Class

Phenylpiperazine antidepressants

Miscellaneous anxiolytics, sedatives and hypnotics

Generic Availability

Lower cost generic

Pricing and Coupons * Prices are without insurance

Quantity	100 each
Strength	50 mg
Per unit^*	$0.20 - $0.21
Cost^*	$20.37 - $20.92

View all Trazodone prices

Quantity	10 capsule
Strength	10 mg
Per unit^*	$1.97 - $1.97
Cost^*	$19.69 - $19.74

View all Zaleplon prices

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Dosage Forms

Oral tablet

Oral capsule

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

7.5 hours

1 hour

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Some potential for abuse

Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.

Pregnancy Category

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Drug Interactions

A total of 674 drugs are known to interact with Trazodone:

138 major drug interactions (503 brand and generic names)
521 moderate drug interactions (2174 brand and generic names)
15 minor drug interactions (71 brand and generic names)

A total of 421 drugs are known to interact with Zaleplon:

28 major drug interactions (148 brand and generic names)
393 moderate drug interactions (1533 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Alcohol can increase the nervous system side effects of traZODone such as dizziness, drowsiness... View more

Taking zaleplon with a high-fat or heavy meal may delay the onset of sleep. For faster sleep... View more

Disease Interactions

First Approval Date

December 24, 1981

August 13, 1999

WADA Class View classifications

N/A

More Information

Patient Resources

Trazodone uses

Professional Resources

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Comparing Trazodone vs Zaleplon

See also:

Vraylar

Lexapro

Rexulti

Abilify

Zoloft

Seroquel

Prozac

Cymbalta

Wellbutrin

Ativan

Further information

Comparing Trazodone vs Zaleplon

See also:

Further information

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