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Zaleplon Side Effects

In Summary

More frequently reported side effects include: amnesia and dizziness. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to zaleplon: oral capsule

Along with its needed effects, zaleplon may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking zaleplon:

Less common
  • Anxiety
  • blurred or double vision
  • not feeling like oneself
  • Nosebleed
  • seeing, hearing, smelling, or feeling things that are not there

Get emergency help immediately if any of the following symptoms of overdose occur while taking zaleplon:

Symptoms of overdose
  • Confusion
  • clumsiness or unsteadiness, severe
  • dizziness or fainting
  • drowsiness, severe
  • weak muscle tone
  • troubled breathing
  • unusual dullness or feeling sluggish

Some side effects of zaleplon may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common Less common

After you stop using this medicine, it may still produce some side effects that need attention. During this period of time, check with your doctor immediately if you notice the following side effects:

  • Abdominal and muscle cramps
  • convulsions (seizures)
  • increased sweating
  • sadness
  • trembling or shaking
  • vomiting

For Healthcare Professionals

Applies to zaleplon: oral capsule

Nervous system

Very common (10% or more): Headache (42%)
Common (1% to 10%): Dizziness, amnesia, confusion, hypertonia, hypesthesia, paresthesia, somnolence, tremor, vertigo, migraine, taste perversion
Uncommon (0.1% to 1%): Abnormal gait, ataxia, circumoral paresthesia, hyperesthesia, hyperkinesia, hypotonia, incoordination, neuralgia, nystagmus
Rare (less than 0.1%): CNS stimulation, cerebral ischemia, dysarthria, dystonia, facial paralysis, hypokinesia, myoclonus, neuropathy, psychomotor retardation, decreased reflexes, increased reflexes, slurred speech, stupor
Frequency not reported: Seizures[Ref]


Common (1% to 10%): Pruritus, rash
Uncommon (0.1% to 1%): Ecchymosis, acne, alopecia, contact dermatitis, dry skin, eczema, maculopapular rash, skin hypertrophy, sweating, urticaria, vesiculobullous rash
Rare (less than 0.1%): Purpura, melanosis, psoriasis, pustular rash, skin discoloration


Common (1% to 10%): Nausea, abdominal pain, colitis, constipation, dry mouth, dyspepsia
Uncommon (0.1% to 1%): Eructation, esophagitis, flatulence, gastritis, gastroenteritis, gingivitis, glossitis, mouth ulceration, stomatitis
Rare (less than 0.1%): Aphthous stomatitis, bruxism, cardiospasm, cheilitis, cholelithiasis, duodenal ulcer, dysphagia, enteritis, gum hemorrhage, increased salivation, intestinal obstruction, peptic ulcer, tongue discoloration, tongue edema, ulcerative stomatitis[Ref]


Common (1% to 10%): Dysmenorrhea
Uncommon (0.1% to 1%): Breast pain, rectal hemorrhage, bladder pain, melena, cystitis, decreased urine stream, dysuria, hematuria, menorrhagia, metrorrhagia, urinary frequency, urinary incontinence, urinary urgency, vaginitis
Rare (less than 0.1%): Albuminuria, delayed menstrual period, leukorrhea, menopause, urethritis, urinary retention, vaginal hemorrhage[Ref]


Common (1% to 10%): Anorexia
Uncommon (0.1% to 1%): Increased appetite, gout, hypercholesteremia, weight gain
Rare (less than 0.1%): Weight loss[Ref]


Common (1% to 10%): Back pain, arthralgia, arthritis, myalgia
Uncommon (0.1% to 1%): Neck rigidity, arthrosis, bursitis, joint disorder (mainly swelling, stiffness, pain), myasthenia, tenosynovitis
Rare (less than 0.1%): Myositis, osteoporosis, trismus[Ref]


Common (1% to 10%): Abnormal vision, eye pain, conjunctivitis
Uncommon (0.1% to 1%): Diplopia, dry eyes, photophobia, watery eyes
Rare (less than 0.1%): Ptosis, abnormality of accommodation, blepharitis, cataract specified, corneal erosion, eye hemorrhage, glaucoma, retinal detachment, visual field defect[Ref]


Common (1% to 10%): Asthenia, malaise, photosensitivity reaction, peripheral edema, ear pain, hyperacusis, parosmia, chest pain, fever
Uncommon (0.1% to 1%): Substernal chest pain, chills, face edema, generalized edema, hangover effect, tinnitus, thirst[Ref]


Common (1% to 10%): Depersonalization, hallucinations, anxiety, depression, nervousness, abnormal thinking (mainly difficulty concentrating)
Uncommon (0.1% to 1%): Agitation, emotional lability, apathy, euphoria, insomnia, decreased libido, impotence
Rare (less than 0.1%): Delusions, hostility, sleep talking, sleep walking
Postmarketing reports: Nightmares


Common (1% to 10%): Epistaxis, bronchitis
Uncommon (0.1% to 1%): Asthma, dyspnea, laryngitis, pneumonia, snoring, voice alteration
Rare (less than 0.1%): Pulmonary embolus, apnea, hiccup, hyperventilation, pleural effusion, increased sputum[Ref]


Uncommon (0.1% to 1%): Angina pectoris, bundle branch block, hypertension, hypotension, palpitation, syncope, tachycardia, vasodilation, ventricular extrasystoles
Rare (less than 0.1%): Bigeminy, cyanosis, pericardial effusion, postural hypotension, sinus bradycardia, thrombophlebitis, ventricular tachycardia


Uncommon (0.1% to 1%): Anemia, lymphadenopathy
Rare (less than 0.1%): Eosinophilia, leukocytosis, lymphocytosis


Uncommon (0.1% to 1%): Kidney calculus, kidney pain


Rare (less than 0.1%): Diabetes mellitus, goiter, hypothyroidism


Rare (less than 0.1%): Abnormal liver function tests, bilirubinemia, increased AST (SGOT), increased ALT (SGPT), biliary pain


Postmarketing reports: Anaphylactic/anaphylactoid reactions


1. "Product Information. Sonata (zaleplon)" Wyeth-Ayerst Laboratories, Philadelphia, PA.

Some side effects of zaleplon may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

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