Paroxetine Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Paroxetine	Rexulti (brexpiprazole)	Bupropion	Enter another drug to compare

Paroxetine

Rexulti (brexpiprazole)

Bupropion

Prescription only

Paroxetine may be used in the treatment of depression or anxiety disorders. Common side effects include headaches and nausea. Taking paroxetine with other medications such as tramadol that also... View more

Prescription only

Rexulti is an atypical antipsychotic that may be used to treat adults with schizophrenia or depression, or used to relieve agitation associated with dementia in Alzheimer's disease. Most people... View more

Prescription only

Bupropion may be used in the treatment of depression or as an aid to smoking cessation; however, side effects may include insomnia, neuropsychiatric adverse events, or seizures. It carries a black... View more

More about Paroxetine

More about Rexulti (brexpiprazole)

More about Bupropion

Ratings & Reviews

Paroxetine has an average rating of 7.1 out of 10 from a total of 1552 ratings on Drugs.com. 63% of reviewers reported a positive effect, while 19% reported a negative effect.

Rexulti has an average rating of 6.6 out of 10 from a total of 499 ratings on Drugs.com. 55% of reviewers reported a positive effect, while 25% reported a negative effect.

Bupropion has an average rating of 7.0 out of 10 from a total of 2913 ratings on Drugs.com. 60% of reviewers reported a positive effect, while 20% reported a negative effect.

View all 1552 reviews

View all 499 reviews

View all 2913 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Weight gain (11.1%)
Anxiety (9.6%)
Sexual dysfunction (9.2%)
Nausea (7.4%)
Tiredness (7.2%)
Depression (6.9%)
Dizziness (6.6%)

View all Paroxetine side effects

Weight gain (21.8%)
Anxiety (9.2%)
Insomnia (7.6%)
Restlessness (6.4%)
Tiredness (6.0%)
Increased appetite (4.8%)
Depression (4.4%)

View all Rexulti side effects

Anxiety (16.4%)
Insomnia (11.7%)
Headaches (7.2%)
Sexual dysfunction (6.3%)
Irritability (6.2%)
Depression (5.6%)
Loss of appetite (5.6%)

View all Bupropion side effects

Drug Class

Selective serotonin reuptake inhibitors

Atypical antipsychotics

Generic Availability

Lower cost generic

Lower cost generic approved

Lower cost generic

Pricing and Coupons * Prices are without insurance

Quantity	100 each
Strength	20 mg
Per unit^*	$0.15
Cost^*	$14.94

View all Paroxetine prices

Quantity	30 tablet
Strength	0.25 mg
Per unit^*	$49.61
Cost^*	$1,488.43

View all Rexulti prices

Quantity	30 each
Strength	150 mg/24 hours
Per unit^*	$0.48
Cost^*	$14.40

View all Bupropion prices

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Dosage Forms

Oral capsule
Oral suspension
Oral tablet
Oral tablet, extended release

Oral tablet

Oral tablet
Oral tablet, extended release

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

21 hours

91 hours

30 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category D Positive evidence of risk

Excluding Brisdelle

Category X Not for use in pregnancy

Brisdelle

See the full pregnancy warnings document.

Summary unavailable.

See the full pregnancy warnings document.

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Drug Interactions

A total of 510 drugs are known to interact with Paroxetine:

106 major drug interactions (469 brand and generic names)
388 moderate drug interactions (1659 brand and generic names)
16 minor drug interactions (48 brand and generic names)

A total of 601 drugs are known to interact with Rexulti:

136 major drug interactions (610 brand and generic names)
462 moderate drug interactions (1722 brand and generic names)
3 minor drug interactions (9 brand and generic names)

A total of 560 drugs are known to interact with Bupropion:

218 major drug interactions (953 brand and generic names)
337 moderate drug interactions (1877 brand and generic names)
5 minor drug interactions (16 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Alcohol can increase the nervous system side effects of PARoxetine such as dizziness, drowsiness... View more

Alcohol can increase the nervous system side effects of brexpiprazole such as dizziness... View more

Using buPROPion with alcohol may increase the risk of uncommon side effects such as seizures... View more

Disease Interactions

First Approval Date

December 29, 1992

July 10, 2015

December 30, 1985

WADA Class View classifications

N/A

More Information

Patient Resources

Paroxetine uses

Rexulti uses

Bupropion uses

Professional Resources

Prescribing information

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Paroxetine Alternatives Compared

See also:

Vraylar

Auvelity

Rexulti

Prozac

Celexa

Paxil

Luvox

Paxil CR

Luvox CR

Sarafem

Further information

Paroxetine Alternatives Compared

See also:

Further information

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