Comparing Pantoprazole vs Simethicone

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Pantoprazole	Simethicone	Enter another drug to compare

Pantoprazole

Simethicone

Prescription only

Pantoprazole is a proton pump inhibitor that decreases acid secretion in the stomach and may be given to relieve the symptoms of heartburn or to allow inflamed tissue in the gastrointestinal tract to... View more

Over-the-counter

Prescribed for Gas, Functional Gastric Disorder, Postoperative Gas Pains, Endoscopy or Radiology Premedication. Simethicone may also be used for purposes not listed in this medication guide.

More about Pantoprazole

More about Simethicone

Ratings & Reviews

Pantoprazole has an average rating of 5.0 out of 10 from a total of 430 ratings on Drugs.com. 37% of reviewers reported a positive effect, while 47% reported a negative effect.

Simethicone has an average rating of 7.7 out of 10 from a total of 57 ratings on Drugs.com. 74% of reviewers reported a positive effect, while 19% reported a negative effect.

View all 430 reviews

View all 57 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Headaches (16.7%)
Anxiety (11.6%)
Dizziness (11.2%)
Nausea (10.9%)
Stomach pain (7.9%)
Bloating (7.2%)
Gas (6.5%)

View all Pantoprazole side effects

Gas (14.0%)
Bloating (7.0%)
Nausea (5.3%)

View all Simethicone side effects

Drug Class

Proton pump inhibitors

Miscellaneous GI agents

Generic Availability

Lower cost generic

Pricing and Coupons * Prices are without insurance

Quantity	50 each
Strength	40 mg
Per unit^*	$0.38 - $0.52
Cost^*	$19.17 - $25.80

View all Pantoprazole prices

Quantity	4 tablet, chewable
Strength	80 mg
Per unit^*	$2.51
Cost^*	$10.05

View all Simethicone prices

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Dosage Forms

Intravenous powder for injection
Intravenous solution
Oral delayed release tablet
Oral granule, enteric coated

Oral capsule
Oral liquid
Oral suspension
Oral tablet, chewable

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

1 hour

N/A

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category B No proven risk in humans

See the full pregnancy warnings document.

Category N Not classified

See the full pregnancy warnings document.

Drug Interactions

A total of 181 drugs are known to interact with Pantoprazole:

17 major drug interactions (44 brand and generic names)
145 moderate drug interactions (1227 brand and generic names)
19 minor drug interactions (142 brand and generic names)

A total of 5 drugs are known to interact with Simethicone:

5 moderate drug interactions (44 brand and generic names)

Alcohol/Food/Lifestyle Interactions

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

Disease Interactions

No known disease interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

First Approval Date

February 02, 2000

N/A

WADA Class View classifications

N/A

More Information

Patient Resources

Simethicone uses

Professional Resources

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Comparing Pantoprazole vs Simethicone

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