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Simethicone

Generic Name: simethicone (sye METH i cone)
Brand Name: Alka-Seltzer Anti-Gas, Bicarsim, Bicarsim Forte, Gas Aide, Gas Free Extra Strength, Gas-X, Infantaire Gas Relief, Little Tummys, Mi-Acid Gas Relief, Mylanta Gas Maximum Strength, Mytab Gas, Phazyme, SimePed, ...show all 48 brand names

Medically reviewed on August 18, 2017

What is simethicone?

Simethicone allows gas bubbles in the stomach and intestines to come together more easily, which allows for easier passage of gas.

Simethicone is used to relieve painful pressure caused by excess gas in the stomach and intestines. Simethicone is for use in babies, children, and adults.

Simethicone may also be used for purposes not listed in this medication guide.

Important Information

Never use more than the recommended dose of simethicone.

Ask a doctor or pharmacist if it is safe for you to take simethicone if you are allergic to any drugs, or if you have any type of serious illness (especially one that affects your stomach or intestines).

Before taking this medicine

You should not use this medication if you are allergic to simethicone.

Ask a doctor or pharmacist if it is safe for you to take this medicine if you are allergic to any drugs, or if you have any type of serious illness (especially one that affects your stomach or intestines).

Simethicone is not expected to harm an unborn baby.

It is not known whether simethicone passes into breast milk or if it could harm a nursing baby. Do not use this medication without medical advice if you are breast-feeding a baby.

The liquid form may contain phenylalanine. Talk to your doctor before using this form of simethicone if you have phenylketonuria (PKU).

How should I take simethicone?

Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Do not take more of this medication than is directed.

Simethicone works best if you take it after meals and at bedtime.

The simethicone chewable tablet must be chewed before swallowing.

Measure liquid medicine with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.

Simethicone liquid drops can be mixed with water, baby formula, or other liquids to make swallowing easier for an infant or child.

Children should never be given more than the recommended dose of simethicone. Call your doctor if the child's gas symptoms do not improve after treatment with simethicone.

Simethicone may be only part of a complete program of treatment that may also include a special diet or increased exercise. It is very important to follow the diet and exercise plan created for you by your doctor or nutrition counselor. You should become very familiar with the list of foods you must avoid to help control your condition.

Store at room temperature away from moisture, heat, and light. Do not allow the liquid form of simethicone to freeze.

What happens if I miss a dose?

Since simethicone is used on an as needed basis, you are not likely to miss a dose. Do not use more of this medication than is directed.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking simethicone?

Ask a doctor or pharmacist before using any other stomach medicine or antacid. Simethicone is contained in many combination medicines. Taking certain products together can cause you to get too much simethicone.

Simethicone side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

Simethicone dosing information

Usual Adult Dose for Flatulence:

40 to 125 mg orally after meals and at bedtime, not to exceed 500 mg/24 hours.

Usual Adult Dose for Functional Gastric Disorder:

40 to 125 mg orally after meals and at bedtime, not to exceed 500 mg/24 hours.

Usual Adult Dose for Postoperative Gas Pains:

40 to 125 mg orally after meals and at bedtime, not to exceed 500 mg/24 hours.

Usual Adult Dose for Endoscopy or Radiology Premedication:

67 mg as an oral suspension in 2.5 mL of water given shortly before the procedure.

Usual Pediatric Dose for Flatulence:

0 to <2 years: 20 mg orally 4 times a day.

2 to 12 years: 40 mg orally 4 times a day. For the 40 mg strips, allow 1 strip to dissolve on the tongue as needed after meals and at bedtime. Do not exceed 6 strips in 24 hours except under the advice and supervision of a physician.


12 to 18 years: 40 to 125 mg orally after meals and at bedtime as needed, not to exceed 500 mg/24 hours.

Usual Pediatric Dose for Endoscopy or Radiology Premedication:

Child >12 years: 67 mg as an oral suspension in 2.5 mL of water given shortly before the procedure.

What other drugs will affect simethicone?

Other drugs may interact with simethicone, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.