Comparing Orphenadrine vs Tizanidine

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Orphenadrine	Tizanidine	Enter another drug to compare

Orphenadrine

Tizanidine

Prescription only

Prescribed for Muscle Spasm, Migraine, Headache. Orphenadrine may also be used for purposes not listed in this medication guide.

Prescription only

Tizanidine may be used to reduce muscle spasms but common side effects include sleepiness, a drop in blood pressure, and a dry mouth. The dosage of tizanidine should be tailored to each person and... View more

More about Orphenadrine

More about Tizanidine

Ratings & Reviews

Orphenadrine has an average rating of 6.7 out of 10 from a total of 83 ratings on Drugs.com. 60% of reviewers reported a positive effect, while 28% reported a negative effect.

Tizanidine has an average rating of 6.2 out of 10 from a total of 381 ratings on Drugs.com. 48% of reviewers reported a positive effect, while 29% reported a negative effect.

View all 83 reviews

View all 381 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Anxiety (12.0%)
Dry mouth (9.6%)
Dizziness (8.4%)
Drowsiness (6.0%)
Lightheadedness (6.0%)
Tremors (6.0%)
Nausea (4.8%)

View all Orphenadrine side effects

Drowsiness (18.9%)
Dry mouth (9.2%)
Hallucinations (6.8%)
Dizziness (6.3%)
Tiredness (5.5%)
Vivid dreams (4.2%)
Headaches (3.7%)

View all Tizanidine side effects

Drug Class

Skeletal muscle relaxants

Skeletal muscle relaxants

Generic Availability

Lower cost generic

Pricing and Coupons * Prices are without insurance

Quantity	20 tablet, extended release
Strength	100 mg
Per unit^*	$1.17
Cost^*	$23.38

View all Orphenadrine prices

Quantity	50 each
Strength	4 mg
Per unit^*	$0.61
Cost^*	$30.51

View all Tizanidine prices

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Dosage Forms

Injectable solution
Oral tablet, extended release

Oral capsule
Oral tablet

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

16 hours

2.5 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Drug Interactions

A total of 399 drugs are known to interact with Orphenadrine:

33 major drug interactions (213 brand and generic names)
365 moderate drug interactions (1542 brand and generic names)
1 minor drug interactions (2 brand and generic names)

A total of 647 drugs are known to interact with Tizanidine:

246 major drug interactions (973 brand and generic names)
399 moderate drug interactions (1598 brand and generic names)
2 minor drug interactions (4 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Alcohol can increase the nervous system side effects of orphenadrine such as dizziness, drowsiness... View more

Using tiZANidine together with alcohol may increase side effects such as dizziness, drowsiness... View more

Disease Interactions

Anticholinergic effects

First Approval Date

November 04, 1959

November 27, 1996

WADA Class View classifications

N/A

More Information

Patient Resources

Tizanidine uses

Professional Resources

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Comparing Orphenadrine vs Tizanidine

See also:

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Further information

Comparing Orphenadrine vs Tizanidine

See also:

Further information

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