Naloxegol Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Naloxegol	Movantik (naloxegol)	Relistor (methylnaltrexone)	Enter another drug to compare

Naloxegol

Movantik (naloxegol)

Relistor (methylnaltrexone)

Prescription only

Prescribed for Opioid-Induced Constipation, Constipation - Chronic, Constipation - Drug Induced, Constipation. Naloxegol may also be used for purposes not listed in this medication guide.

Prescription only

Prescribed for Opioid-Induced Constipation, Constipation - Chronic, Constipation - Drug Induced. Movantik may also be used for purposes not listed in this medication guide.

Prescription only

Prescribed for Opioid-Induced Constipation, Constipation - Drug Induced, Constipation - Chronic. Relistor may also be used for purposes not listed in this medication guide.

More about Naloxegol

More about Movantik (naloxegol)

More about Relistor (methylnaltrexone)

Ratings & Reviews

Naloxegol has an average rating of 4.9 out of 10 from a total of 272 ratings on Drugs.com. 35% of reviewers reported a positive effect, while 48% reported a negative effect.

Movantik has an average rating of 4.9 out of 10 from a total of 265 ratings on Drugs.com. 35% of reviewers reported a positive effect, while 47% reported a negative effect.

Relistor has an average rating of 6.6 out of 10 from a total of 61 ratings on Drugs.com. 59% of reviewers reported a positive effect, while 31% reported a negative effect.

View all 272 reviews

View all 265 reviews

View all 61 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Cramps (29.0%)
Withdrawal (14.3%)
Constipation (13.2%)
Nausea (13.2%)
Diarrhea (12.9%)
Sweating (10.7%)
Pain (9.6%)

View all Naloxegol side effects

Cramps (28.7%)
Withdrawal (14.7%)
Nausea (13.2%)
Constipation (12.8%)
Diarrhea (12.1%)
Sweating (10.6%)
Pain (9.4%)

View all Movantik side effects

Cramps (16.4%)
Constipation (11.5%)
Gas (11.5%)
Nausea (8.2%)
Sweating (8.2%)
Vomiting (6.6%)
Diarrhea (4.9%)

View all Relistor side effects

Drug Class

Peripheral opioid receptor antagonists

Peripheral opioid receptor antagonists

Peripheral opioid receptor antagonists

Generic Availability

N/A

No lower cost generic approved

Lower cost generic approved

Pricing and Coupons * Prices are without insurance

We could not find an exact match for this medicine. Try searching the Price Guide directly.

Quantity	100 each
Strength	25 mg
Per unit^*	$14.29
Cost^*	$1,428.82

View all Movantik prices

Quantity	0.6 mL
Strength	12 mg/0.6 mL
Per unit^*	$289.82
Cost^*	$173.89

View all Relistor prices

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Dosage Forms

N/A

Oral tablet

Oral tablet
Subcutaneous kit
Subcutaneous solution

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

11 hours

8 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Category B No proven risk in humans

See the full pregnancy warnings document.

Drug Interactions

A total of 245 drugs are known to interact with Naloxegol:

65 major drug interactions (201 brand and generic names)
100 moderate drug interactions (303 brand and generic names)
80 minor drug interactions (209 brand and generic names)

A total of 245 drugs are known to interact with Movantik:

65 major drug interactions (201 brand and generic names)
100 moderate drug interactions (303 brand and generic names)
80 minor drug interactions (209 brand and generic names)

A total of 25 drugs are known to interact with Relistor:

24 moderate drug interactions (60 brand and generic names)
1 minor drug interactions (2 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Do not consume grapefruit or grapefruit juice during treatment with naloxegol. Grapefruit juice... View more

Do not consume grapefruit or grapefruit juice during treatment with naloxegol. Grapefruit juice... View more

Food may reduce the absorption of methylnaltrexone when taken orally, which may lead to lower blood... View more

Disease Interactions

First Approval Date

September 16, 2014

April 24, 2008

WADA Class View classifications

N/A

More Information

Patient Resources

Movantik uses

Professional Resources

Prescribing information

Prescribing information

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Naloxegol Alternatives Compared

See also:

Amitiza

Movantik

Botox

Relistor

Symproic

Linzess

Trulance

Motegrity

Pizensy

Lactitol

Further information

Naloxegol Alternatives Compared

See also:

Further information

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