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Generic Name: naloxegol (nal OX ee gol)
Brand Names: Movantik

What is Movantik?

Movantik (naloxegol) is a prescription medicine that blocks certain effects of narcotic medicines. An opioid is sometimes called a narcotic.

Movantik is used to treat opioid induced constipation (OIC) caused by prescription pain medicines called narcotic or opiates, in adults with long-lasting (chronic) pain that is not caused by cancer. Naloxegol treats constipation without reducing the pain-relieving effects of the narcotic.

Movantik is used in people who have been taking narcotic pain medicine for at least 4 weeks, to treat chronic pain that is not caused by cancer.

Important information

You should not use Movantik if you have a blockage in your stomach or intestines.

Tell your doctor if you have symptoms of opioid withdrawal, such as anxiety, feeling irritable, sweating, chills, yawning, stomach pain, and diarrhea.

Stop using this medicine and call your doctor at once if you have severe stomach pain and/or diarrhea (which can lead to serious medical problems).

Many drugs can interact with naloxegol, and some drugs should not be used together. Tell your doctor about all medicines you use, and those you start or stop using during your treatment with Movantik.

Before taking this medicine

You should not use Movantik if you are allergic to naloxegol, or if you have:

  • a blockage in your stomach or intestines.

Some medicines can cause unwanted or dangerous effects when used with naloxegol. Your doctor may need to change your treatment plan if you use certain drugs such as:

  • imatinib;

  • isoniazid;

  • nefazodone;

  • an antibiotic - clarithromycin, telithromycin;

  • antifungal medicine - itraconazole, ketoconazole, posaconazole, voriconazole;

  • heart medication - nicardipine, quinidine; or

  • antiviral medicine to treat hepatitis C or HIV/AIDS - atazanavir, boceprevir, cobicistat, delavirdine, fosamprenavir, indinavir, nelfinavir, ritonavir, saquinavir, telaprevir.

To make sure this medicine is safe for you, tell your doctor if you have ever had:

  • a stomach or intestinal disorder (including Crohn's disease, diverticulitis, or Ogilvie's syndrome);

  • stomach cancer, colorectal cancer;

  • a perforation (a hole or tear) in your esophagus, stomach, or intestines;

  • liver disease; or

  • kidney disease.

If you use Movantik while you are pregnant, your baby could have opioid withdrawal symptoms. Tell your doctor if you are pregnant or plan to become pregnant.

Do not breast-feed while taking naloxegol. This medicine may cause opioid withdrawal symptoms in a nursing baby.

Movantik is not approved for use by anyone younger than 18 years old.

How should I take Movantik?

Movantik is usually taken once per day. Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Take this medicine on an empty stomach, at least 1 hour before or 2 hours after your first meal of the day.

If you cannot swallow a Movantik tablet whole, you may crush the tablet into powder and mix it with 4 ounces of water. Stir and drink this mixture right away. To get the entire dose, add a little more water to the same glass, swirl gently and drink immediately.

Movantik can also be given through a nasogastric (NG) feeding tube. Crush the tablet into powder and mix it in a container with 2 ounces of water. Draw this mixture into a 60-milliliter syringe. Attach the syringe to the NG tube and push the plunger down to empty the syringe into the tube. Then add 2 more ounces of water to the same container in which you mixed the water and tablet powder. Draw this water into the syringe and use it to flush the NG tube and wash the contents down.

Call your doctor if your symptoms do not improve after 3 days of treatment.

After you stop using your pain medication, you should also stop taking Movantik.

Store at room temperature away from moisture and heat.

Movantik dosing information

Usual Adult Dose for Opioid Induced Constipation - Chronic:

Initial dose: 25 mg orally once a day
Maintenance dose: 25 mg orally once daily. Dose may be reduced to 12.5 mg orally once a day for patients unable to tolerate higher dose, patients with moderate, severe, or end-stage renal impairment, and patients who require treatment with some medications that may inhibit the metabolism of naloxegol.

Comments: Prior to initiation, discontinue all maintenance laxative therapy; laxatives can be used as needed for suboptimal response after 3 days.

Use: For the treatment of opioid-induced constipation in adult patients with chronic non-cancer pain.

See also: Dosage Information (in more detail)

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Movantik?

Do not use any other laxatives that your doctor has not prescribed.

Grapefruit and grapefruit juice may interact with naloxegol and lead to unwanted side effects. Avoid the use of grapefruit products while taking Movantik.

Movantik side effects

Get emergency medical help if you have any signs of an allergic reaction to Movantik: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using Movantik and call your doctor at once if you have:

  • severe stomach pain that will not go away;

  • severe, persistent, or worsening abdominal pain, diarrhea, or nausea;

  • severe diarrhea; or

  • symptoms of narcotic medicine withdrawal - anxiety, feeling irritable, sweating, chills, yawning, stomach pain, diarrhea.

Common Movantik side effects may include:

  • nausea, vomiting, stomach pain;

  • diarrhea, gas; or

  • headache.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Movantik?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Other drugs may interact with naloxegol, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Where can I get more information?

  • Your pharmacist can provide more information about Movantik.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Movantik only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2018 Cerner Multum, Inc. Version: 4.01. Revision Date: 2017-06-08, 11:58:20 AM.