Skip to main content


Generic name: naldemedinenal-DEM-e-deen ]
Drug class: Peripheral opioid receptor antagonists

Medically reviewed by Philip Thornton, DipPharm. Last updated on Apr 26, 2024.

What is Symproic?

Symproic blocks certain effects of opioid medication. An opioid is sometimes called a narcotic.

Symproic reduces constipation caused by opioid pain medicine used to treat severe chronic pain. Naldemedine works by treating constipation without reducing the pain-relieving effects of the narcotic.

Symproic as been shown to be effective in people who have taken opioid pain medicines (for at least 4 weeks) to treat chronic pain that is not caused by cancer.


You should not use Symproic if you have a blockage in your stomach or intestines.

Stop using Symproic and call your doctor at once if you have severe stomach pain that does not go away (this can lead to serious medical problems).

Tell your doctor if you have symptoms of opioid withdrawal, such as sweating, feeling hot or cold, tremors, fast heartbeats, agitation, runny nose, watery eyes, vomiting, and diarrhea.

Naldemedine may be habit-forming. Never share this medicine with another person. MISUSE OF HABIT-FORMING MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH.

Before taking this medicine

You should not use Symproic if you are allergic to naldemedine, or if you have:

To make sure Symproic is safe for you, tell your doctor if you have ever had:

If you use this medicine while you are pregnant, your baby could have opioid withdrawal symptoms. Tell your doctor if you are pregnant or if you become pregnant.

This medicine may cause opioid withdrawal symptoms in a nursing baby. Do not breast-feed while taking naldemedine, and for at least 3 days after your last dose.

Symproic is not approved for use by anyone younger than 18 years old.

How should I take Symproic?

Symproic is usually taken once per day. Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

You may take this medicine with or without food.

Call your doctor if your symptoms do not improve, or if they get worse.

Symproic may not work as well in people who have been taking opioids for less than 4 weeks.

Store in the original container at room temperature, away from moisture and heat.

After you stop using opioid pain medicine, you should also stop taking Symproic.

Dosing information

Usual Adult Dose for Constipation - Drug Induced:

0.2 mg orally once a day

-Discontinue therapy if treatment with the opioid pain medication is discontinued.

Use: For the treatment of opioid-induced constipation in adults with chronic non-cancer pain, including patients with chronic pain related to prior cancer or its treatment who do not require frequent (e.g. weekly) opioid dosage escalation.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What to avoid

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Symproic side effects

Get emergency medical help if you have signs of an allergic reaction to Symproic: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Tell your doctor if you have symptoms of opioid withdrawal: sweating, fever, chills, warmth or tingling in your face, tremors, fast heartbeats, feeling anxious or agitated, yawning, runny nose, sneezing, watery eyes, stomach pain, nausea, vomiting, and diarrhea.

Stop using this medicine and call your doctor at once if you have:

Common Symproic side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Symproic?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Other drugs may interact with naldemedine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Popular FAQ

Any drug that is classified as an "opioid" can cause constipation. Examples of commonly prescribed opioids that may cause this side effect include morphine, tramadol, fentanyl, methadone, hydrocodone, codeine and oxycodone. Continue reading

More FAQ

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Symproic only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.