Symproic Side Effects
Generic Name: naldemedine
Note: This document contains side effect information about naldemedine. Some of the dosage forms listed on this page may not apply to the brand name Symproic.
For the Consumer
Applies to naldemedine: oral tablet
Along with its needed effects, naldemedine (the active ingredient contained in Symproic) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking naldemedine:More common
- Abdominal or stomach pain
- Fast heartbeat
- hives, itching, or rash
- joint pain, stiffness, or swelling
- loss of appetite
- redness of the skin
- swelling of the eyelids, face, lips, hands, or feet
- tightness in the chest
- troubled breathing or swallowing
- Bloody, black, or tarry stools
- feeling cold
- increased sweating
- redness on the face, neck, arms, and upper chest
- severe abdominal or stomach pain, cramping, or burning
- vomiting of material that looks like coffee grounds, severe and continuing
Some side effects of naldemedine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:Incidence not known
- Fast, pounding, or irregular heartbeat or pulse
- increased tearing
For Healthcare Professionals
Applies to naldemedine: oral tablet
The most commonly reported adverse reactions have included abdominal pain, diarrhea, and nausea.[Ref]
Frequency not reported: Bronchospasm, rash
During clinical trials, 2 patients developed symptoms of hypersensitivity. One had bronchospasm and the other had a rash.
Adverse reactions consistent with opioid withdrawal have been reported. These reactions may have included hyperhidrosis, hot flush or flushing, chills, tremor, tachycardia, anxiety, agitation, yawning, rhinorrhea, increased lacrimation, sneezing, feeling cold, pyrexia, vomiting, diarrhea, or abdominal pain. The incidence of adverse reactions of opioid withdrawal in 2 pooled studies was similar to placebo (8/542 vs 3/546); in a 52-week study the incidence in drug-treated patients was 3% (20/621) versus 1% (9/619) for placebo.
Common (1% to 10%): Opioid withdrawal
Very common (10% or more): Abdominal pain (up to 11%)
Common (1% to 10%): Diarrhea, nausea, gastroenteritis, vomiting
1. "Product Information. Symproic (naldemedine)." Shionogi USA Inc, Florham Park, NJ.
Some side effects of Symproic may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
More about Symproic (naldemedine)
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Images
- Drug Interactions
- Support Group
- Pricing & Coupons
- En Español
- 0 Reviews – Add your own review/rating
- Drug class: peripheral opioid receptor antagonists
Related treatment guides
Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.