Peripheral opioid receptor antagonists
What are Peripheral opioid receptor antagonists?
Peripheral opioid receptor antagonists bind to the peripheral opioid receptors, such as those in the gastrointestinal tract and block unwanted effects caused by opioids.
They are not able to penetrate the blood brain barrier so do not antagonize central nervous system opioid receptors, therefore the analgesic effects of opioids is not affected.
Peripheral opioid receptor antagonists are given with opioids to prevent opioid-induced constipation.
List of Peripheral opioid receptor antagonists
Generic name: naloxegol
Generic name: methylnaltrexone
Generic name: naldemedine
Generic name: alvimopan
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Medical conditions treated or associated with peripheral opioid receptor antagonists:
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