Movantik Side Effects
Generic Name: naloxegol
Note: This document contains side effect information about naloxegol. Some of the dosage forms listed on this page may not apply to the brand name Movantik.
Common side effects of Movantik include: abdominal pain. Other side effects include: diarrhea and flatulence. See below for a comprehensive list of adverse effects.
For the Consumer
Applies to naloxegol: oral tablet
Along with its needed effects, naloxegol (the active ingredient contained in Movantik) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking naloxegol:Less common
- Bloody, black or tarry stools
- severe abdominal or stomach pain, cramping, or burning
- trouble breathing
- vomiting of material that looks like coffee grounds, severe and continuous
Some side effects of naloxegol may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More common
- excess air or gas in the stomach or bowels
- full feeling
- passing of gas
For Healthcare Professionals
Applies to naloxegol: oral tablet
Common (1% to 10%): Possible opioid withdrawal (3 or more symptoms on the same day including, but not limited to hyperhidrosis, chills, diarrhea, abdominal pain, anxiety, irritability, and yawning)[Ref]
Possible opioid withdrawal defined as at least 3 adverse reactions potentially related to opioid withdrawal occurring on the same day and not all related to the gastrointestinal system occurred in less than 1% of patients (5 of 441) receiving the 12.5 mg dose and 3% of patients (14 of 446) receiving the 25 mg dose. Symptoms included, but were not limited to hyperhidrosis, chills, diarrhea, abdominal pain, anxiety, irritability, and yawning. For patients receiving methadone, higher frequencies of gastrointestinal adverse reactions were observed compared with other opioids.[Ref]
Very common (10% or more): Abdominal pain (up to 21%)
Common (1% to 10%): Diarrhea, nausea, flatulence, vomiting[Ref]
Reports of severe abdominal pain and/or diarrhea resulting in hospitalization have occurred. Most cases were reported at the higher dose and within a few days of initiating therapy.[Ref]
Common (1% to 10%): Hyperhidrosis[Ref]
Common (1% to 10%): Headache[Ref]
Common (1% to 10%): Nasopharyngitis[Ref]
1. "Product Information. Movantik (naloxegol)." Astra-Zeneca Pharmaceuticals, Wilmington, DE.
2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
3. Cerner Multum, Inc. "Australian Product Information." O 0
Some side effects of Movantik may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
More about Movantik (naloxegol)
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- Drug class: peripheral opioid receptor antagonists
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