Movantik Side Effects
Generic name: naloxegol
Medically reviewed by Drugs.com. Last updated on May 15, 2024.
Note: This document provides detailed information about Movantik Side Effects associated with naloxegol. Some dosage forms listed on this page may not apply specifically to the brand name Movantik.
Applies to naloxegol: oral tablet.
Precautions
It is very important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it.
Do not take this medicine together with clarithromycin, itraconazole, or ketoconazole. Using these medicines together may cause or worsen opioid withdrawal symptoms, such as anxiety, chills, diarrhea, irritability, stomach pain, sweating, and yawning.
Call your doctor right away if you have severe stomach pain or diarrhea while you are using this medicine.
This medicine may cause a tear (perforation) in your stomach or bowels. Check with your doctor right away if you have a severe stomach pain that does not go away.
Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal (eg, St. John's wort) or vitamin supplements.
Common side effects of Movantik
Some side effects of naloxegol may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common side effects
- Bloated feeling
- excess air or gas in the stomach or bowels
- full feeling
- passing of gas
Less common side effects
- headache
- vomiting
Serious side effects of Movantik
Along with its needed effects, naloxegol (the active ingredient contained in Movantik) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking naloxegol:
Less common side effects
- anxiety
- chills
- diarrhea
- increased sweating
- irritability
- stomach pain
- yawning
Incidence not known
For healthcare professionals
Applies to naloxegol: oral tablet.
General adverse events
The most common adverse reactions include abdominal pain, nausea, diarrhea, headache, vomiting, and flatulence.[Ref]
Other
- Common (1% to 10%): Possible opioid withdrawal (3 or more symptoms on the same day including, but not limited to hyperhidrosis, chills, diarrhea, abdominal pain, anxiety, irritability, and yawning)[Ref]
Possible opioid withdrawal defined as at least 3 adverse reactions potentially related to opioid withdrawal occurring on the same day and not all related to the gastrointestinal system occurred in less than 1% of patients (5 of 441) receiving the 12.5 mg dose and 3% of patients (14 of 446) receiving the 25 mg dose. Symptoms included, but were not limited to hyperhidrosis, chills, diarrhea, abdominal pain, anxiety, irritability, and yawning. For patients receiving methadone, higher frequencies of gastrointestinal adverse reactions were observed compared with other opioids.[Ref]
Gastrointestinal
- Very common (10% or more): Abdominal pain (up to 21%)
- Common (1% to 10%): Diarrhea, nausea, flatulence, vomiting[Ref]
Reports of severe abdominal pain and/or diarrhea resulting in hospitalization have occurred. Most cases were reported at the higher dose and within a few days of initiating therapy.[Ref]
Dermatologic
- Common (1% to 10%): Hyperhidrosis[Ref]
Nervous system
- Common (1% to 10%): Headache[Ref]
Respiratory
- Common (1% to 10%): Nasopharyngitis[Ref]
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References
1. Cerner Multum, Inc. "UK Summary of Product Characteristics."
2. Cerner Multum, Inc. "Australian Product Information."
3. (2014) "Product Information. Movantik (naloxegol)." Astra-Zeneca Pharmaceuticals
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Further information
Movantik side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.