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Movantik Side Effects

Generic Name: naloxegol

Note: This page contains information about the side effects of naloxegol. Some of the dosage forms included on this document may not apply to the brand name Movantik.

In Summary

Common side effects of Movantik include: abdominal pain. Other side effects include: diarrhea and flatulence. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to naloxegol: oral tablet

In addition to its needed effects, some unwanted effects may be caused by naloxegol (the active ingredient contained in Movantik). In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking naloxegol:

Less common:
  • Abdominal or stomach pain
  • anxiety
  • chills
  • diarrhea
  • increased sweating
  • irritability
  • yawning
Incidence not known:
  • Bloody, black or tarry stools
  • heartburn
  • indigestion
  • nausea
  • severe abdominal or stomach pain, cramping, or burning
  • trouble breathing
  • vomiting of material that looks like coffee grounds, severe and continuing

Minor Side Effects

Some of the side effects that can occur with naloxegol may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Bloated
  • excess air or gas in the stomach or bowels
  • full feeling
  • passing gas
Less common:
  • Headache
  • vomiting

For Healthcare Professionals

Applies to naloxegol: oral tablet

General

The most common adverse reactions include abdominal pain, nausea, diarrhea, headache, vomiting, and flatulence.[Ref]

Other

Common (1% to 10%): Possible opioid withdrawal (3 or more symptoms on the same day including, but not limited to hyperhidrosis, chills, diarrhea, abdominal pain, anxiety, irritability, and yawning)[Ref]

Possible opioid withdrawal defined as at least 3 adverse reactions potentially related to opioid withdrawal occurring on the same day and not all related to the gastrointestinal system occurred in less than 1% of patients (5 of 441) receiving the 12.5 mg dose and 3% of patients (14 of 446) receiving the 25 mg dose. Symptoms included, but were not limited to hyperhidrosis, chills, diarrhea, abdominal pain, anxiety, irritability, and yawning. For patients receiving methadone, higher frequencies of gastrointestinal adverse reactions were observed compared with other opioids.[Ref]

Gastrointestinal

Very common (10% or more): Abdominal pain (up to 21%)
Common (1% to 10%): Diarrhea, nausea, flatulence, vomiting[Ref]

Dermatologic

Common (1% to 10%): Hyperhidrosis[Ref]

Nervous system

Common (1% to 10%): Headache[Ref]

Respiratory

Common (1% to 10%): Nasopharyngitis[Ref]

References

1. "Product Information. Movantik (naloxegol)." Astra-Zeneca Pharmaceuticals, Wilmington, DE.

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Not all side effects for Movantik may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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