Relistor Side Effects
Generic Name: methylnaltrexone
Note: This page contains side effects data for the generic drug methylnaltrexone. It is possible that some of the dosage forms included below may not apply to the brand name Relistor.
Common side effects of Relistor include: abdominal pain, nausea, and flatulence. See below for a comprehensive list of adverse effects.
For the Consumer
Applies to methylnaltrexone: oral tablet
Other dosage forms:
As well as its needed effects, methylnaltrexone (the active ingredient contained in Relistor) may cause unwanted side effects that require medical attention.
Major Side Effects
If any of the following side effects occur while taking methylnaltrexone, check with your doctor immediately:Incidence not known:
- fear or nervousness
- increased sweating
- severe abdominal or stomach pain
- severe or persistent diarrhea
Minor Side Effects
Some methylnaltrexone side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:Less common:
- Full or bloated feeling
- muscle spasms
- pressure in the stomach
- runny nose
- swelling of abdominal or stomach area
For Healthcare Professionals
Applies to methylnaltrexone: oral tablet, subcutaneous kit, subcutaneous solution
Very common (10% or more): Abdominal pain (up to 29%), flatulence (up to 13%), nausea (up to 12%)
Common (1% to 10%): Diarrhea,
Postmarketing reports: Perforation, cramping, vomiting[Ref]
Common (1% to 10%): Dizziness, tremor[Ref]
Common (1% to 10%): Hyperhidrosis, flushing[Ref]
Common (1% to 10%): Chills
Postmarketing reports: Malaise, pain, cases of opioid withdrawal[Ref]
In an open-label, uncontrolled study (n=1034), 4 myocardial infarctions (1 fatal), 1 stroke (fatal), 1 fatal cardiac arrest, and 1 sudden death were reported. It is not possible to establish a relationship between these events and use of this drug.[Ref]
Frequency not reported: Myocardial infarctions[Ref]
The most common adverse reactions included abdominal pain, nausea, diarrhea, hyperhidrosis, hot flush, tremor, and chills.[Ref]
Common (1% to 10%): Injection site reactions including stinging, burning, pain, redness, and edema[Ref]
1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
2. Cerner Multum, Inc. "Australian Product Information." O 0
3. "Product Information. Relistor (methylnaltrexone)." Wyeth Laboratories, Philadelphia, PA.
It is possible that some side effects of Relistor may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.
More about Relistor (methylnaltrexone)
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