Naloxegol Side Effects
Commonly reported side effects of naloxegol include: abdominal pain. Other side effects include: diarrhea and flatulence. See below for a comprehensive list of adverse effects.
For the Consumer
Applies to naloxegol: oral tablet
As well as its needed effects, naloxegol may cause unwanted side effects that require medical attention.
Major Side Effects
If any of the following side effects occur while taking naloxegol, check with your doctor immediately:Less common:
- Abdominal or stomach pain
- increased sweating
- Bloody, black or tarry stools
- severe abdominal or stomach pain, cramping, or burning
- trouble breathing
- vomiting of material that looks like coffee grounds, severe and continuing
Minor Side Effects
Some naloxegol side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:More common:
- excess air or gas in the stomach or bowels
- full feeling
- passing gas
For Healthcare Professionals
Applies to naloxegol: oral tablet
The most common adverse reactions include abdominal pain, nausea, diarrhea, headache, vomiting, and flatulence.[Ref]
Common (1% to 10%): Possible opioid withdrawal (3 or more symptoms on the same day including, but not limited to hyperhidrosis, chills, diarrhea, abdominal pain, anxiety, irritability, and yawning)[Ref]
Possible opioid withdrawal defined as at least 3 adverse reactions potentially related to opioid withdrawal occurring on the same day and not all related to the gastrointestinal system occurred in less than 1% of patients (5 of 441) receiving the 12.5 mg dose and 3% of patients (14 of 446) receiving the 25 mg dose. Symptoms included, but were not limited to hyperhidrosis, chills, diarrhea, abdominal pain, anxiety, irritability, and yawning. For patients receiving methadone, higher frequencies of gastrointestinal adverse reactions were observed compared with other opioids.[Ref]
Very common (10% or more): Abdominal pain (up to 21%)
Common (1% to 10%): Diarrhea, nausea, flatulence, vomiting[Ref]
Common (1% to 10%): Hyperhidrosis[Ref]
Common (1% to 10%): Headache[Ref]
Common (1% to 10%): Nasopharyngitis[Ref]
1. "Product Information. Movantik (naloxegol)." Astra-Zeneca Pharmaceuticals, Wilmington, DE.
2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
It is possible that some side effects of naloxegol may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.
More about naloxegol
- Other brands: Movantik
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