Comparing Methotrexate vs Votrient
Methotrexate Remove Methotrexate from your drug comparison | Votrient Remove Votrient from your drug comparison |
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Methotrexate Remove Methotrexate from your drug comparison | Votrient pazopanib Remove Votrient from your drug comparison | ||||||||||||||||
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Methotrexate may be considered for the treatment of psoriasis or rheumatoid arthritis if other treatments have failed. It may also be used in certain cancers. Side effects can be severe and... View more |
Prescribed for Soft Tissue Sarcoma, Renal Cell Carcinoma. Votrient may also be used for purposes not listed in this medication guide. |
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Prescription only |
Prescription only |
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Ratings & ReviewsRecent helpful reviews |
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6.7
For Rheumatoid Arthritis: I have been on 15mg then 20mg for two years. Then developed constant explosive diarrhea, dizziness, and confusion. Judged to be allergic, and told to stop the medication immediately. The symptoms continue...how long before it gets better? I am not taking anything for RA right now after a week off methotrexate. |
8.2
For Renal Cell Carcinoma: I have been on Votrient since Jan 2010. Started with a right kidney in 1999. In 2009 my family doctor suggested that I have a pulmonary doctor run some CTs to see what he thought. After 8 months of CTs, I had to go and get a biopsy and it proved 2 clear and 2 renal cell carcinoma had appeared between my lungs. I checked a couple of oncologists in town. Been on the medicine since January 2010 and have little significant change. A little diarrhea once in a while and headaches, some dizziness on occasion but no significant change. Feel real good about the treatment. Would recommend it to anyone. For Renal Cell Carcinoma: RCC detected May 2018. Left kidney removed 20 yrs ago, started Votrient 800 mg on June 1, 2018. First follow up PET scan will be August 30th, to see how it is doing. Most side effects, diarrhea most days, hair turning white, bruising easily, now feet are very tender, even thou I am following instructions on applying urea lotion on both feet and hands twice daily. Take the Votrient first thing out of bed in the AM, with hopes I flush out early enough to have an active life, although I am limited some days, but must always know where restrooms are. When I started the Votrient, I went directly to 800mg, and have stayed on it daily since, I feel that I must tough it out, and stay with it, to give it the best chance to work. Praying for good scan results. God Bless you folks that are in the same fight, stay on meds, stay as active as you can (I walk 20-30 minutes every day), and eat to keep weight up which will help with your strength. My prayers are with you. |
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Drug Class |
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Side Effects |
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Commonly reported side effects include: increased liver enzymes. See the full methotrexate side effects document. |
Common side effects include: bleeding tendency disorder, abdominal pain, decreased serum glucose, decreased serum magnesium, decreased serum phosphate, diarrhea, fatigue, hypertension, increased serum alanine aminotransferase, increased serum aspartate aminotransferase, increased serum bilirubin, leukopenia, nausea, neutropenia, thrombocytopenia, vomiting, and anorexia. See the full Votrient side effects document. |
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Pricing and Coupons* Prices are without insurance |
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View all methotrexate prices |
View all Votrient prices |
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Generic Availability |
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Yes (this medicine) |
No |
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Dosage Form(s) Available |
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Brand Names |
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Methotrexate LPF Sodium, Otrexup, Rasuvo, RediTrex, Trexall, Xatmep |
N/A |
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Half LifeThe half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. |
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12 hours |
30.9 hours |
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CSA Schedule**View glossary of terms. |
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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Pregnancy Category |
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Category X
Not for use in pregnancy
See the full Pregnancy Warnings document. |
Category D
Positive evidence of risk
See the full Pregnancy Warnings document. |
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FDA Alerts |
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N/A |
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Drug Interactions |
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A total of 589 drugs are known to interact with methotrexate:
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A total of 542 drugs are known to interact with Votrient:
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Alcohol/Food/Lifestyle Interactions |
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Disease Interactions |
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First Approval Date |
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December 07, 1953 |
October 19, 2009 |
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WADA ClassView World Anti-Doping Agency classifications. |
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N/A |
N/A |
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More Information |
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Consumer Resources |
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Professional Resources |
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Related Treatment Guide |
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** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
For Rheumatoid Arthritis: I had taken MTX in past but it did not work out for me due to rash proplem caused by MTX so Doctor recommended Sulfasalazine and it worked out very good for about 4 years but the end of friendship came to us...Sulfasalazine was not effective anymore. I met a Doctor who practice natrual madicine also ER Dortor at the local hospital....He recommended 3 natrual Supplements for RA and pain( Turmeric, Wobenzym N, White Willow) and they are very effective (on me) and it is better than Chemical based medications. I have been off from those deadly medications for 5 months now.