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Votrient Side Effects

Generic name: pazopanib

Medically reviewed by Philip Thornton, DipPharm. Last updated on Sep 9, 2023.

Note: This document contains side effect information about pazopanib. Some dosage forms listed on this page may not apply to the brand name Votrient.

Applies to pazopanib: oral tablet.


Oral route (Tablet)

Severe and fatal hepatotoxicity has occurred during clinical trials. Monitor hepatic function. Interrupt, reduce, or discontinue treatment as recommended.

Serious side effects of Votrient

Along with its needed effects, pazopanib (the active ingredient contained in Votrient) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking pazopanib:

More common

Less common

Other side effects of Votrient

Some side effects of pazopanib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

For Healthcare Professionals

Applies to pazopanib: oral tablet.


Very common (10% or more): Increased ALT (up to 53%), increased AST (up to 53%), increased total bilirubin (up to 36%), increased alkaline phosphatase (up to 32%)

Common (1% to 10%): Abnormal hepatic function, hepatotoxicity, decreased alkaline phosphatase, increased gamma-glutamyltransferase (GGT), abnormal liver function test

Uncommon (0.1% to 1%): Jaundice, drug-induced liver injury, hepatic failure, increased hepatic enzyme

Postmarketing reports: Increased GGT[Ref]


Very common (10% or more): Hypertension (up to 42%), myocardial dysfunction (up to 11%), chest pain (up to 10%)

Common (1% to 10%): Venous thromboembolic events, cardiac dysfunction, bradycardia, QT prolongation, myocardial infarction or ischemia, hot flush, flushing

Uncommon (0.1% to 1%): Torsades de pointes, congestive heart failure, fatal arterial thromboembolic events, hypertensive crisis[Ref]


Very common (10% or more): Tumor pain (up to 32%), hemorrhagic events (up to 13%)

Common (1% to 10%): Edema, epistaxis, mouth ulceration, dry mouth, mucosal inflammation, gingival infection, hiccups

Uncommon (0.1% to 1%): Fatal hemorrhage, cerebral/intracranial hemorrhage, infections (with or without neutropenia), infectious peritonitis, menorrhagia, metrorrhagia, oropharyngeal pain

Postmarketing reports: Infections (with or without neutropenia)[Ref]


Very common (10% or more): Increased creatinine (up to 26%), proteinuria (up to 12%)

Common (1% to 10%): Increased urea

Uncommon (0.1% to 1%): Nephrotic syndrome, thrombotic microangiopathy (TMA)

Postmarketing reports: Thrombotic microangiopathy (TMA)[Ref]


Very common (10% or more): Diarrhea (up to 59%), nausea (up to 56%), vomiting (up to 33%), gastrointestinal pain (up to 23%), abdominal pain (up to 14%), mucositis (up to 12%), stomatitis (up to 11%)

Common (1% to 10%): Dyspepsia, flatulence, abdominal distension

Uncommon (0.1% to 1%): Perforation or fistula, fatal perforations, hematochezia, melena, frequent bowel movements, hematemesis, pancreatitis, peritonitis

Postmarketing reports: Pancreatitis, flatulence[Ref]

Nervous system

Very common (10% or more): Fatigue (up to 65%), dysgeusia (up to 28%), headache (up to 23%), dizziness (up to 11%)

Common (1% to 10%): Insomnia, dysphonia, lethargy, paresthesia, peripheral sensory neuropathy, chills

Uncommon (0.1% to 1%): Hypoesthesia, somnolence, mucous membrane disorder, cerebral infarction, transient ischemic attack, cerebrovascular accident, ischemic stroke, posterior reversible encephalopathy syndrome/reversible posterior leukoencephalopathy syndrome (PRES/RPLS)

Postmarketing reports: PRES/RPLS[Ref]


Common (1% to 10%): Hypothyroidism, increased thyroid stimulating hormone

Uncommon (0.1% to 1%): Abnormal thyroid function test[Ref]


-Renal cell carcinoma (RCC): The most commonly observed adverse reactions (20% or more) were diarrhea, hypertension, hair color change, nausea, fatigue, anorexia, and vomiting.

-Soft tissue sarcoma (STS): The most commonly observed adverse reactions (20% or more) were fatigue, diarrhea, nausea, decreased weight, hypertension, decreased appetite, vomiting, tumor pain, hair color changes, musculoskeletal pain, headache, dysgeusia, dyspnea, and skin hypopigmentation.[Ref]


Very common (10% or more): Hair color changes (up to 39%), skin hypopigmentation (up to 21%), exfoliative rash (up to 18%), palmar-plantar erythrodysesthesia syndrome (up to 18%), alopecia (up to 12%), rash (up to 11%)

Common (1% to 10%): Dry skin, skin depigmentation, nail disorder, pruritus, erythema, hyperhidrosis

Uncommon (0.1% to 1%): Skin exfoliation, photosensitivity reaction, erythematous rash, skin disorder, macular rash, pruritic rash, vesicular rash, papular rash, skin ulcer[Ref]


Common (1% to 10%): Hematuria[Ref]


Very common (10% or more): Leukopenia (up to 44%), lymphocytopenia (up to 43%), thrombocytopenia (up to 36%), neutropenia (up to 34%), anemia (up to 27%)

Common (1% to 10%): Decreased white blood cell count

Uncommon (0.1% to 1%): Decreased platelet count[Ref]


Very common (10% or more): Decreased weight (up to 48%), increased glucose (up to 45%), decreased appetite (up to 40%), increased albumin (up to 34%), decreased albumin (up to 34%), decreased phosphorus (up to 34%), decreased calcium (up to 33%), decreased sodium (up to 31%), increased potassium (up to 27%), decreased magnesium (up to 26%), anorexia (up to 22%), decreased glucose (up to 17%)

Common (1% to 10%): Increased lipase, increased amylase, dehydration, abnormal blood cholesterol[Ref]


Very common (10% or more): Musculoskeletal pain (up to 23%), myalgia (up to 23%), asthenia (up to 14%)

Common (1% to 10%): Arthralgia, muscle spasms[Ref]


Common (1% to 10%): Blurred vision

Uncommon (0.1% to 1%): Eyelash discoloration


Frequency not reported: Increased toxicity and mortality with other cancer therapies


Very common (10% or more): Dyspnea (up to 20%), cough (up to 17%)

Common (1% to 10%): Pneumothorax

Uncommon (0.1% to 1%): Rhinorrhea[Ref]

Frequently asked questions


1. Cerner Multum, Inc. UK Summary of Product Characteristics.

2. Cerner Multum, Inc. Australian Product Information.

3. Product Information. Votrient (pazopanib). GlaxoSmithKline. 2009.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.