Generic name: atezolizumab and hyaluronidase [ A-te-zoe-LIZ-ue-mab-and-HYE-al-ure-ON-i-dase ]
Brand name: Tecentriq Hybreza
Dosage form: subcutaneous solution (tqjs 1875 mg-30,000 units/15 mL)
Drug class: Anti-PD-1 and PD-L1 monoclonal antibodies (immune checkpoint inhibitors)

Medically reviewed by Drugs.com on Oct 29, 2024. Written by Cerner Multum.

What is atezolizumab and hyaluronidase?

Atezolizumab and hyaluronidase is used to treat certain cancers of the skin, lung, liver, or certain types cancer that forms in muscles, fat, or nerves.

Atezolizumab and hyaluronidase is used when the cancer has spread to other parts of the body (metastatic), or cannot be removed by surgery. Atezolizumab and hyaluronidase may be used alone or in combination with other cancer drugs.

Your doctor may perform a biopsy to test your cancer for a protein called "PD-L1," or a specific genetic marker (an abnormal "BRAF," "EGFR," or "ALK" gene).

Atezolizumab and hyaluronidase is sometimes given after other cancer treatments did not work or have stopped working.

Atezolizumab and hyaluronidase may also be used for purposes not listed in this medication guide.

Atezolizumab and hyaluronidase side effects

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Some side effects may occur during the injection. Tell your medical caregivers if you feel dizzy, nauseated, light-headed, itchy, sweaty, or have a headache, chest tightness, back pain, trouble breathing, or swelling in your face.

Atezolizumab and hyaluronidase may cause serious side effects. Call your doctor at once if you have:

• new or worsening cough, shortness of breath;

• chest pain, irregular heartbeats;

• severe stomach pain, nausea, vomiting, diarrhea, bloody or tarry stools;

• kidney problems--urinating less, blood in your urine, loss of appetite, swelling in your ankles;

• liver problems--right-sided upper stomach pain, drowsiness, easy bruising or bleeding, dark urine, jaundice (yellowing of the skin or eyes);

• skin problems--itching, fever, flu-like symptoms, swollen lymph nodes, painful sores or ulcers in mouth, nose, throat, or genital area;

• nervous system problems--neck stiffness, increased sensitivity to light, confusion, memory problems, problems with balance, severe muscle weakness, muscle cramps, numbness or tingling in your hands or feet, vision problems, eye pain or redness;

• low red blood cells (anemia)--pale skin, unusual tiredness, feeling light-headed or short of breath, cold hands and feet;

• signs of infection--fever, flu symptoms, cough, back pain, painful or frequent urination; or

• signs of a hormonal disorder--frequent or unusual headaches, extreme tiredness, dizziness or fainting, mood or behavior changes, hoarse or deepened voice, increased hunger or thirst, increased urination, constipation, hair loss, feeling cold, weight gain, or weight loss.

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects of atezolizumab and hyaluronidase may include:

• anxiety;

• diarrhea, constipation, nausea, vomiting, loss of appetite;

• bleeding;

• fever, infections;

• cough, feeling short of breath;

• liver problems;

• mouth sores or swelling;

• irregular heartbeats, high blood pressure, abnormal blood or urine tests;

• headache, tiredness, weakness

• joint, muscle, or bone pain;

• numbness, pain or tingling in your hands or feet;

• swelling in your legs or arms;

• rash, itching, sunburn or being more sensitive to sunlight; or

• hair loss.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Related/similar drugs

Warnings

Atezolizumab and hyaluronidase affects your immune system and may cause it to attack normal healthy tissues or organs, leading to serious or life-threatening medical problems.

Call your doctor at once if you have new or worsening symptoms such as: chest pain, cough, breathing problems, stomach pain, vomiting, changes in appetite or weight, increased thirst or urination, painful urination, headaches, neck stiffness, vision problems, tiredness, mood changes, muscle weakness, hair loss, feeling cold, bleeding or bruising, diarrhea, bloody or tarry stools, dark urine, or yellowing of the skin or eyes.

Before taking this medicine

Tell your doctor if you have or have ever had:

• an infection;

• an immune system disorder such as lupus, ulcerative colitis, or Crohn's disease;

• an organ transplant;

• radiation treatment to your chest area;

• a breathing disorder; or

• a nervous system disorder such as myasthenia gravis or Guillain Barré syndrome.

Tell your doctor if you have received or plan to receive a stem cell transplant using donor stem cells.

May harm an unborn baby. You may need a pregnancy test to make sure you are not pregnant. Use effective birth control while using atezolizumab and hyaluronidase and for at least 5 months after your last dose. Tell your doctor if you become pregnant.

It may be harder for you to get pregnant while you are using atezolizumab and hyaluronidase. You should still use birth control to prevent pregnancy because the medicine can harm an unborn baby.

Do not breastfeed while receiving this medicine, and for at least 5 months after your last dose.

How is atezolizumab and hyaluronidase given?

Atezolizumab and hyaluronidase is injected under the skin, usually once every 3 weeks. A healthcare provider will give you this injection in the thigh.

This medicine must be given slowly, and the injection can take up to 7 minutes to complete.

If you receive atezolizumab and hyaluronidase to treat a type of skin cancer called melanoma, you will also be given two other medications to take by mouth. Follow your doctor's dosing instructions very carefully.

You may be given other medications to help prevent serious side effects or allergic reaction. Keep taking these medicines for as long as your doctor has prescribed.

Atezolizumab and hyaluronidase helps your immune system fight against tumor cells, but your immune system may attack normal healthy tissues or organs. When this happens, you may develop serious or life-threatening medical problems. You will need frequent medical tests.

Your doctor will determine how long to treat you with atezolizumab and hyaluronidase.

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your atezolizumab and hyaluronidase injection.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while receiving atezolizumab and hyaluronidase?

Atezolizumab and hyaluronidase could make you sunburn more easily. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

What other drugs will affect atezolizumab and hyaluronidase?

Other drugs may affect atezolizumab and hyaluronidase, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.

Atezolizumab/hyaluronidase Biosimilars

Biosimilar and interchangeable products are biological products that are highly similar to and have no clinically meaningful differences from the reference product.

Reference products

These are biological products that have already been approved by the FDA, against which biosimilar products are compared. There is 1 for atezolizumab/hyaluronidase.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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